Emergence of KPC-8-producing K. pneumoniae infection without prior exposure to ceftazidime/avibactam: the threat of de novo infections by ceftazidime/avibactam-resistant KPC variants

[Data availability] This Whole Genome Shotgun project has been deposited at DDBJ/ENA/GenBank under the Bioproject accession number PRJNA1026946.

Detalles Bibliográficos
Autores: Mateo-Vargas, María Alejandra, Rodríguez-Pallares, Arca-Suárez, Jorge, López-Cerero, Lorena, Rodríguez-Iglesias, Manuel, Galán-Sánchez, Fátima
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/400127
Acceso en línea:http://hdl.handle.net/10261/400127
https://api.elsevier.com/content/abstract/scopus_id/105007291867
Access Level:acceso abierto
Palabra clave:KPC-31
KPC-8
Klebsiella pneumoniae
Antimicrobial resistance
Cefiderocol
Ceftazidime/avibactam
Evolution
Imipenem/relebactam
Meropenem/vaborbactam
β-lactamase
id ES_32c6f97b802e5dfc8c4aed6ee76c4425
oai_identifier_str oai:digital.csic.es:10261/400127
network_acronym_str ES
network_name_str España
repository_id_str
spelling Emergence of KPC-8-producing K. pneumoniae infection without prior exposure to ceftazidime/avibactam: the threat of de novo infections by ceftazidime/avibactam-resistant KPC variantsMateo-Vargas, María AlejandraRodríguez-PallaresArca-Suárez, JorgeLópez-Cerero, LorenaRodríguez-Iglesias, ManuelGalán-Sánchez, FátimaKPC-31KPC-8Klebsiella pneumoniaeAntimicrobial resistanceCefiderocolCeftazidime/avibactamEvolutionImipenem/relebactamMeropenem/vaborbactamβ-lactamase[Data availability] This Whole Genome Shotgun project has been deposited at DDBJ/ENA/GenBank under the Bioproject accession number PRJNA1026946.De novo infections caused by ceftazidime/avibactam-resistant KPC variants are rarely reported. We characterize the evolution of a KPC-8-producing Klebsiella pneumoniae strain involved in a primary infection without previous ceftazidime/avibactam treatment. During a 15-month follow-up, changes in carbapenem susceptibility due to porin alterations were observed, remaining susceptible to meropenem/vaborbactam, imipenem/relebactam, and cefiderocol. High- and low-permeability recombinant Escherichia coli isolates analysis revealed that, unlike the widespread ceftazidime/avibactam-resistant variant KPC-31, KPC-8 confers ceftazidime/avibactam resistance without decreasing carbapenemase activity.This study was supported by Menarini, with funding directly provided to the institution. This work was also supported by the Instituto de Salud Carlos III through project PI22/01212, by Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC, CB21/13/00055), integrated in the National Plan for Scientific Research, Development and Technological Innovation 2013–2016, by the ISCIII-General Subdirection of Assessment and Promotion of the Research-European Regional Development Fund (FEDER) “A way of making Europe” and by the Axencia Galega de Innovación (GAIN), Consellería de Innovación, Consellería de Emprego e Industria through “Proxecto de excelencia” IN607D2024/008 to J.A.-S. and co-funded by the European Union. S.R.-P. was financially supported by the Río Hortega program (ISCII, CM23/00104). J.A.-S. was financially supported by the Juan Rodés program (ISCIII, JR21/00026). Conceptualization and methodology: F.G-.S., M.R.-I., and J.A.-S. Software and formal analysis: M.A.M.-V., S.R.-P., and L.L.-C. Investigation and validation: M.A.M.-V., J.A.-S., and S.R.-P. Resources: F.G.-S., M.R.-I., L.L.-C., and J.A.-S. Data curation: M.A.M.-V. Writing—original draft: M.A.M.-V., F.G.-S., and S.R.-P. Writing—review and editing: all authors. Visualization: M.A.M.-V., F.G.-S., J.A.-S., and L.L.-C. Supervision: all authors. Project administration: F.G.-S. and M.R.-I. Funding acquisition: F.G.-S., J.A.-S., and S.R.-P. All authors amended and approved the final version of the manuscript.Peer reviewedAmerican Society for MicrobiologyInstituto de Salud Carlos IIICentro de Investigación Biomédica en Red de Enfermedades Infecciosas (España)European CommissionAxencia Galega de InnovaciónMateo-Vargas, María Alejandra [0000-0003-0854-9703]López-Cerero, Lorena [0000-0001-8950-4384]Galán-Sánchez, Fátima [0000-0003-0101-6701]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202520252025info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/400127https://api.elsevier.com/content/abstract/scopus_id/105007291867reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica, Técnica y de Innovación 2021-2023/PI22%2F01212The underlying dataset has been published as supplementary material of the article in the publisher platform at DOI https://doi.org/10.1128/aac.01494-24https://doi.org/10.1128/aac.01494-24Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/4001272026-05-22T06:33:51Z
dc.title.none.fl_str_mv Emergence of KPC-8-producing K. pneumoniae infection without prior exposure to ceftazidime/avibactam: the threat of de novo infections by ceftazidime/avibactam-resistant KPC variants
title Emergence of KPC-8-producing K. pneumoniae infection without prior exposure to ceftazidime/avibactam: the threat of de novo infections by ceftazidime/avibactam-resistant KPC variants
spellingShingle Emergence of KPC-8-producing K. pneumoniae infection without prior exposure to ceftazidime/avibactam: the threat of de novo infections by ceftazidime/avibactam-resistant KPC variants
Mateo-Vargas, María Alejandra
KPC-31
KPC-8
Klebsiella pneumoniae
Antimicrobial resistance
Cefiderocol
Ceftazidime/avibactam
Evolution
Imipenem/relebactam
Meropenem/vaborbactam
β-lactamase
title_short Emergence of KPC-8-producing K. pneumoniae infection without prior exposure to ceftazidime/avibactam: the threat of de novo infections by ceftazidime/avibactam-resistant KPC variants
title_full Emergence of KPC-8-producing K. pneumoniae infection without prior exposure to ceftazidime/avibactam: the threat of de novo infections by ceftazidime/avibactam-resistant KPC variants
title_fullStr Emergence of KPC-8-producing K. pneumoniae infection without prior exposure to ceftazidime/avibactam: the threat of de novo infections by ceftazidime/avibactam-resistant KPC variants
title_full_unstemmed Emergence of KPC-8-producing K. pneumoniae infection without prior exposure to ceftazidime/avibactam: the threat of de novo infections by ceftazidime/avibactam-resistant KPC variants
title_sort Emergence of KPC-8-producing K. pneumoniae infection without prior exposure to ceftazidime/avibactam: the threat of de novo infections by ceftazidime/avibactam-resistant KPC variants
dc.creator.none.fl_str_mv Mateo-Vargas, María Alejandra
Rodríguez-Pallares
Arca-Suárez, Jorge
López-Cerero, Lorena
Rodríguez-Iglesias, Manuel
Galán-Sánchez, Fátima
author Mateo-Vargas, María Alejandra
author_facet Mateo-Vargas, María Alejandra
Rodríguez-Pallares
Arca-Suárez, Jorge
López-Cerero, Lorena
Rodríguez-Iglesias, Manuel
Galán-Sánchez, Fátima
author_role author
author2 Rodríguez-Pallares
Arca-Suárez, Jorge
López-Cerero, Lorena
Rodríguez-Iglesias, Manuel
Galán-Sánchez, Fátima
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Instituto de Salud Carlos III
Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (España)
European Commission
Axencia Galega de Innovación
Mateo-Vargas, María Alejandra [0000-0003-0854-9703]
López-Cerero, Lorena [0000-0001-8950-4384]
Galán-Sánchez, Fátima [0000-0003-0101-6701]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv KPC-31
KPC-8
Klebsiella pneumoniae
Antimicrobial resistance
Cefiderocol
Ceftazidime/avibactam
Evolution
Imipenem/relebactam
Meropenem/vaborbactam
β-lactamase
topic KPC-31
KPC-8
Klebsiella pneumoniae
Antimicrobial resistance
Cefiderocol
Ceftazidime/avibactam
Evolution
Imipenem/relebactam
Meropenem/vaborbactam
β-lactamase
description [Data availability] This Whole Genome Shotgun project has been deposited at DDBJ/ENA/GenBank under the Bioproject accession number PRJNA1026946.
publishDate 2025
dc.date.none.fl_str_mv 2025
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/400127
https://api.elsevier.com/content/abstract/scopus_id/105007291867
url http://hdl.handle.net/10261/400127
https://api.elsevier.com/content/abstract/scopus_id/105007291867
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica, Técnica y de Innovación 2021-2023/PI22%2F01212
The underlying dataset has been published as supplementary material of the article in the publisher platform at DOI https://doi.org/10.1128/aac.01494-24
https://doi.org/10.1128/aac.01494-24
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv American Society for Microbiology
publisher.none.fl_str_mv American Society for Microbiology
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869405696584318976
score 15.812429

Similares en LA Referencia