Influence of ECAP process on mechanical, corrosion and bacterial properties of Zn-2Ag alloy for wound closure devices
Actual polymeric wound closure devices are not optimal for load-bearing applications due to the low mechanical properties and the risk of inflammation and bacterial infection mainly produced by multifilament and braided configurations. Biodegradable metallic Zn alloys are promising materials candida...
| Autores: | , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2023 |
| País: | España |
| Institución: | Universitat Politècnica de Catalunya (UPC) |
| Repositorio: | UPCommons. Portal del coneixement obert de la UPC |
| Idioma: | inglés |
| OAI Identifier: | oai:upcommons.upc.edu:2117/386334 |
| Acceso en línea: | https://hdl.handle.net/2117/386334 https://dx.doi.org/10.1016/j.matdes.2023.111817 |
| Access Level: | acceso abierto |
| Palabra clave: | Biomedical materials Nanotechnology Binary alloys Biomaterials Equal channel angular pressing Nanoindentation Ultrafine-grained materials Zinc alloys Materials biomèdics Nanotecnologia Àrees temàtiques de la UPC::Enginyeria dels materials |
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Influence of ECAP process on mechanical, corrosion and bacterial properties of Zn-2Ag alloy for wound closure devicesGarcía Mintegui, Claudia|||0000-0001-8785-7848Goncharov, IvanOrtiz Membrado, Laia|||0000-0001-9646-3226Jiménez Piqué, Emilio|||0000-0002-6950-611XGinebra Molins, Maria Pau|||0000-0002-4700-5621Vedani, MaurizioCortina Pallás, José Luis|||0000-0002-3719-5118Pegueroles Neyra, Marta|||0000-0002-7895-8337Biomedical materialsNanotechnologyBinary alloysBiomaterialsEqual channel angular pressingNanoindentationUltrafine-grained materialsZinc alloysMaterials biomèdicsNanotecnologiaÀrees temàtiques de la UPC::Enginyeria dels materialsActual polymeric wound closure devices are not optimal for load-bearing applications due to the low mechanical properties and the risk of inflammation and bacterial infection mainly produced by multifilament and braided configurations. Biodegradable metallic Zn alloys are promising materials candidates; however, mechanical performance, corrosion behaviour, and biological response should be controlled in order to inhibit the risk of inflammation and bacterial infection. To this end, a Zn-2Ag (2 wt% Ag) alloy was processed by ECAP to evaluate the concurrent combined effect of grain refinement and Ag alloying on biodegradation and antibacterial activity. Two ECAP cycles were successfully applied to a Zn-2Ag alloy obtaining a homogeneous ultra-fine-grained structure in which nanoindentation maps suggested isotropic mechanical properties. Lower UTS and YS with higher elongation was reported after ECAP with similar corrosion rates as before processing. ECAP processed samples showed a homogeneous Ag+ release below the minimum inhibitory concentration for S. Aureus and no antibacterial effect was observed by diffusion. As expected, the presence of Ag in Zn-Ag alloys reduced bacterial attachment. Nevertheless, ECAP processed Zn-2Ag provided an excellent antibacterial activity after 3 h probably caused by the uniformly degraded and thus, non– stable, surface observed after bacterial adhesion.Peer ReviewedElsevier20232023-04-0120232023-04-18journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/2117/386334https://dx.doi.org/10.1016/j.matdes.2023.111817reponame:UPCommons. Portal del coneixement obert de la UPCinstname:Universitat Politècnica de Catalunya (UPC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:upcommons.upc.edu:2117/3863342026-05-27T15:37:01Z |
| dc.title.none.fl_str_mv |
Influence of ECAP process on mechanical, corrosion and bacterial properties of Zn-2Ag alloy for wound closure devices |
| title |
Influence of ECAP process on mechanical, corrosion and bacterial properties of Zn-2Ag alloy for wound closure devices |
| spellingShingle |
Influence of ECAP process on mechanical, corrosion and bacterial properties of Zn-2Ag alloy for wound closure devices García Mintegui, Claudia|||0000-0001-8785-7848 Biomedical materials Nanotechnology Binary alloys Biomaterials Equal channel angular pressing Nanoindentation Ultrafine-grained materials Zinc alloys Materials biomèdics Nanotecnologia Àrees temàtiques de la UPC::Enginyeria dels materials |
| title_short |
Influence of ECAP process on mechanical, corrosion and bacterial properties of Zn-2Ag alloy for wound closure devices |
| title_full |
Influence of ECAP process on mechanical, corrosion and bacterial properties of Zn-2Ag alloy for wound closure devices |
| title_fullStr |
Influence of ECAP process on mechanical, corrosion and bacterial properties of Zn-2Ag alloy for wound closure devices |
| title_full_unstemmed |
Influence of ECAP process on mechanical, corrosion and bacterial properties of Zn-2Ag alloy for wound closure devices |
| title_sort |
Influence of ECAP process on mechanical, corrosion and bacterial properties of Zn-2Ag alloy for wound closure devices |
| dc.creator.none.fl_str_mv |
García Mintegui, Claudia|||0000-0001-8785-7848 Goncharov, Ivan Ortiz Membrado, Laia|||0000-0001-9646-3226 Jiménez Piqué, Emilio|||0000-0002-6950-611X Ginebra Molins, Maria Pau|||0000-0002-4700-5621 Vedani, Maurizio Cortina Pallás, José Luis|||0000-0002-3719-5118 Pegueroles Neyra, Marta|||0000-0002-7895-8337 |
| author |
García Mintegui, Claudia|||0000-0001-8785-7848 |
| author_facet |
García Mintegui, Claudia|||0000-0001-8785-7848 Goncharov, Ivan Ortiz Membrado, Laia|||0000-0001-9646-3226 Jiménez Piqué, Emilio|||0000-0002-6950-611X Ginebra Molins, Maria Pau|||0000-0002-4700-5621 Vedani, Maurizio Cortina Pallás, José Luis|||0000-0002-3719-5118 Pegueroles Neyra, Marta|||0000-0002-7895-8337 |
| author_role |
author |
| author2 |
Goncharov, Ivan Ortiz Membrado, Laia|||0000-0001-9646-3226 Jiménez Piqué, Emilio|||0000-0002-6950-611X Ginebra Molins, Maria Pau|||0000-0002-4700-5621 Vedani, Maurizio Cortina Pallás, José Luis|||0000-0002-3719-5118 Pegueroles Neyra, Marta|||0000-0002-7895-8337 |
| author2_role |
author author author author author author author |
| dc.subject.none.fl_str_mv |
Biomedical materials Nanotechnology Binary alloys Biomaterials Equal channel angular pressing Nanoindentation Ultrafine-grained materials Zinc alloys Materials biomèdics Nanotecnologia Àrees temàtiques de la UPC::Enginyeria dels materials |
| topic |
Biomedical materials Nanotechnology Binary alloys Biomaterials Equal channel angular pressing Nanoindentation Ultrafine-grained materials Zinc alloys Materials biomèdics Nanotecnologia Àrees temàtiques de la UPC::Enginyeria dels materials |
| description |
Actual polymeric wound closure devices are not optimal for load-bearing applications due to the low mechanical properties and the risk of inflammation and bacterial infection mainly produced by multifilament and braided configurations. Biodegradable metallic Zn alloys are promising materials candidates; however, mechanical performance, corrosion behaviour, and biological response should be controlled in order to inhibit the risk of inflammation and bacterial infection. To this end, a Zn-2Ag (2 wt% Ag) alloy was processed by ECAP to evaluate the concurrent combined effect of grain refinement and Ag alloying on biodegradation and antibacterial activity. Two ECAP cycles were successfully applied to a Zn-2Ag alloy obtaining a homogeneous ultra-fine-grained structure in which nanoindentation maps suggested isotropic mechanical properties. Lower UTS and YS with higher elongation was reported after ECAP with similar corrosion rates as before processing. ECAP processed samples showed a homogeneous Ag+ release below the minimum inhibitory concentration for S. Aureus and no antibacterial effect was observed by diffusion. As expected, the presence of Ag in Zn-Ag alloys reduced bacterial attachment. Nevertheless, ECAP processed Zn-2Ag provided an excellent antibacterial activity after 3 h probably caused by the uniformly degraded and thus, non– stable, surface observed after bacterial adhesion. |
| publishDate |
2023 |
| dc.date.none.fl_str_mv |
2023 2023-04-01 2023 2023-04-18 |
| dc.type.none.fl_str_mv |
journal article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/2117/386334 https://dx.doi.org/10.1016/j.matdes.2023.111817 |
| url |
https://hdl.handle.net/2117/386334 https://dx.doi.org/10.1016/j.matdes.2023.111817 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ |
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openAccess |
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application/pdf |
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Elsevier |
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Elsevier |
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reponame:UPCommons. Portal del coneixement obert de la UPC instname:Universitat Politècnica de Catalunya (UPC) |
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Universitat Politècnica de Catalunya (UPC) |
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UPCommons. Portal del coneixement obert de la UPC |
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UPCommons. Portal del coneixement obert de la UPC |
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15.300724 |