Cardiac progenitors cells for vascular repair

The heart is the first functional organ to develop, and cardiomyocytes (cardiac muscle cells) are the essential- and specific-cell type that supports its function during the entire lifespan, being highly resistant to cell damage and aging. Cardiomyocytes occupy ¿ 80% of the volume of mammalian heart...

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Detalhes bibliográficos
Autores: Herrero, Diego, Bernad, Antonio
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2019
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositório:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/240070
Acesso em linha:http://hdl.handle.net/10261/240070
Access Level:Acceso aberto
Palavra-chave:Heart
Progenitor
Bmi1
Neovascularization
Infarction
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spelling Cardiac progenitors cells for vascular repairHerrero, DiegoBernad, AntonioHeartProgenitorBmi1NeovascularizationInfarctionThe heart is the first functional organ to develop, and cardiomyocytes (cardiac muscle cells) are the essential- and specific-cell type that supports its function during the entire lifespan, being highly resistant to cell damage and aging. Cardiomyocytes occupy ¿ 80% of the volume of mammalian heart, however, they are relatively few in total number compared with non-myocyte cells (endothelial cells, smooth muscle cells, fibroblasts; ¿ 70% of total cardiac cells) [1]. Both myocytes and non-myocytes respond to physiological and pathological insults and their maladaptive responses are linked with the pathogenesis of the cardiac tissue. During the last decade, various studies have identified cardiac progenitor-like cells, including immature cardiomyocytes, that contribute to the low cardiomyocyte turnover (< 2% per year), decreasing their contribution in an age-dependent manner. While cardiac regenerative response is effective in embryo and neonatal period (until 7th day after birth), the regeneration is particularly limited from adolescence where ischemic injury lead to the formation of a fibrotic scar and to the reduction in the heart's pumping capacity in mice (reviewed in [2])......Impact JournalsConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2021202120192021info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/240070reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.18632/aging.101840Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2400702026-05-22T06:33:51Z
dc.title.none.fl_str_mv Cardiac progenitors cells for vascular repair
title Cardiac progenitors cells for vascular repair
spellingShingle Cardiac progenitors cells for vascular repair
Herrero, Diego
Heart
Progenitor
Bmi1
Neovascularization
Infarction
title_short Cardiac progenitors cells for vascular repair
title_full Cardiac progenitors cells for vascular repair
title_fullStr Cardiac progenitors cells for vascular repair
title_full_unstemmed Cardiac progenitors cells for vascular repair
title_sort Cardiac progenitors cells for vascular repair
dc.creator.none.fl_str_mv Herrero, Diego
Bernad, Antonio
author Herrero, Diego
author_facet Herrero, Diego
Bernad, Antonio
author_role author
author2 Bernad, Antonio
author2_role author
dc.contributor.none.fl_str_mv Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Heart
Progenitor
Bmi1
Neovascularization
Infarction
topic Heart
Progenitor
Bmi1
Neovascularization
Infarction
description The heart is the first functional organ to develop, and cardiomyocytes (cardiac muscle cells) are the essential- and specific-cell type that supports its function during the entire lifespan, being highly resistant to cell damage and aging. Cardiomyocytes occupy ¿ 80% of the volume of mammalian heart, however, they are relatively few in total number compared with non-myocyte cells (endothelial cells, smooth muscle cells, fibroblasts; ¿ 70% of total cardiac cells) [1]. Both myocytes and non-myocytes respond to physiological and pathological insults and their maladaptive responses are linked with the pathogenesis of the cardiac tissue. During the last decade, various studies have identified cardiac progenitor-like cells, including immature cardiomyocytes, that contribute to the low cardiomyocyte turnover (< 2% per year), decreasing their contribution in an age-dependent manner. While cardiac regenerative response is effective in embryo and neonatal period (until 7th day after birth), the regeneration is particularly limited from adolescence where ischemic injury lead to the formation of a fibrotic scar and to the reduction in the heart's pumping capacity in mice (reviewed in [2])......
publishDate 2019
dc.date.none.fl_str_mv 2019
2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/240070
url http://hdl.handle.net/10261/240070
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://dx.doi.org/10.18632/aging.101840
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Impact Journals
publisher.none.fl_str_mv Impact Journals
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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