Cardiac progenitors cells for vascular repair
The heart is the first functional organ to develop, and cardiomyocytes (cardiac muscle cells) are the essential- and specific-cell type that supports its function during the entire lifespan, being highly resistant to cell damage and aging. Cardiomyocytes occupy ¿ 80% of the volume of mammalian heart...
| Autores: | , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2019 |
| País: | España |
| Institución: | Consejo Superior de Investigaciones Científicas (CSIC) |
| Repositorio: | DIGITAL.CSIC. Repositorio Institucional del CSIC |
| OAI Identifier: | oai:digital.csic.es:10261/240070 |
| Acceso en línea: | http://hdl.handle.net/10261/240070 |
| Access Level: | acceso abierto |
| Palabra clave: | Heart Progenitor Bmi1 Neovascularization Infarction |
| Sumario: | The heart is the first functional organ to develop, and cardiomyocytes (cardiac muscle cells) are the essential- and specific-cell type that supports its function during the entire lifespan, being highly resistant to cell damage and aging. Cardiomyocytes occupy ¿ 80% of the volume of mammalian heart, however, they are relatively few in total number compared with non-myocyte cells (endothelial cells, smooth muscle cells, fibroblasts; ¿ 70% of total cardiac cells) [1]. Both myocytes and non-myocytes respond to physiological and pathological insults and their maladaptive responses are linked with the pathogenesis of the cardiac tissue. During the last decade, various studies have identified cardiac progenitor-like cells, including immature cardiomyocytes, that contribute to the low cardiomyocyte turnover (< 2% per year), decreasing their contribution in an age-dependent manner. While cardiac regenerative response is effective in embryo and neonatal period (until 7th day after birth), the regeneration is particularly limited from adolescence where ischemic injury lead to the formation of a fibrotic scar and to the reduction in the heart's pumping capacity in mice (reviewed in [2])...... |
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