Calcium hydroxide-loaded nanoparticles dispersed in thermosensitive gel as a novel intracanal medicament

Design, produce and assess the viability of a novel nanotechnological antibacterial thermo-sensible intracanal medicament This involves encapsulating calcium hydroxide (Ca(OH)2 ) within polylactic-co-glycolic acid (PLGA) nanoparticles (NPs) and dispersing them in a thermosensitive gel (Ca(OH)2 -NPs-...

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Authors: Roig, Xavier, Halbaut, Lyda, Elmsmari, Firas, Pareja, Rubén, Arrien, Aizea, Duran-Sindreu, Fernando, Delgado, Luis María, Espina, Marta, García, María Luisa, Sánchez, José Antonio González, Sánchez-López, Elena
Format: article
Status:Versión aceptada para publicación
Publication Date:2024
Country:España
Institution:Consejo Superior de Investigaciones Científicas (CSIC)
Repository:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/349868
Online Access:http://hdl.handle.net/10261/349868
https://api.elsevier.com/content/abstract/scopus_id/85186223078
Access Level:Open access
Keyword:Nanoparticles
PLGA
Calcium hydroxide
Endodontic
Gels
Intracanal medication
http://metadata.un.org/sdg/3
Ensure healthy lives and promote well-being for all at all ages
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spelling Calcium hydroxide-loaded nanoparticles dispersed in thermosensitive gel as a novel intracanal medicamentRoig, XavierHalbaut, LydaElmsmari, FirasPareja, RubénArrien, AizeaDuran-Sindreu, FernandoDelgado, Luis MaríaEspina, MartaGarcía, María LuisaSánchez, José Antonio GonzálezSánchez-López, ElenaNanoparticlesPLGACalcium hydroxideEndodonticGelsIntracanal medicationhttp://metadata.un.org/sdg/3Ensure healthy lives and promote well-being for all at all agesDesign, produce and assess the viability of a novel nanotechnological antibacterial thermo-sensible intracanal medicament This involves encapsulating calcium hydroxide (Ca(OH)2 ) within polylactic-co-glycolic acid (PLGA) nanoparticles (NPs) and dispersing them in a thermosensitive gel (Ca(OH)2 -NPs-gel). In addition, perform in vitro and ex vivo assessments to evaluate tissue irritation and penetration capacity into dentinal tubules in comparison to free Ca(OH)2 .Fi-Sdur grant from the Generalitat de Catalunya for the grant that allowed carrying out this study (2022 FISDU 00360). The authors want to acknowledge the Bosch and Gimpera Foundation by the project F2i_PdC_2021-002 (code FBG 600324) and European Regional Development Fund, grant/award number: PROD_00141.Peer reviewedWiley-Blackwell0000-0001-8684-835XConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202420242024info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Postprintinfo:eu-repo/semantics/acceptedVersionhttp://hdl.handle.net/10261/349868https://api.elsevier.com/content/abstract/scopus_id/85186223078reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)InglésInternational endodontic journalhttps://doi.org/10.1111/iej.14041Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3498682026-05-22T06:33:51Z
dc.title.none.fl_str_mv Calcium hydroxide-loaded nanoparticles dispersed in thermosensitive gel as a novel intracanal medicament
title Calcium hydroxide-loaded nanoparticles dispersed in thermosensitive gel as a novel intracanal medicament
spellingShingle Calcium hydroxide-loaded nanoparticles dispersed in thermosensitive gel as a novel intracanal medicament
Roig, Xavier
Nanoparticles
PLGA
Calcium hydroxide
Endodontic
Gels
Intracanal medication
http://metadata.un.org/sdg/3
Ensure healthy lives and promote well-being for all at all ages
title_short Calcium hydroxide-loaded nanoparticles dispersed in thermosensitive gel as a novel intracanal medicament
title_full Calcium hydroxide-loaded nanoparticles dispersed in thermosensitive gel as a novel intracanal medicament
title_fullStr Calcium hydroxide-loaded nanoparticles dispersed in thermosensitive gel as a novel intracanal medicament
title_full_unstemmed Calcium hydroxide-loaded nanoparticles dispersed in thermosensitive gel as a novel intracanal medicament
title_sort Calcium hydroxide-loaded nanoparticles dispersed in thermosensitive gel as a novel intracanal medicament
dc.creator.none.fl_str_mv Roig, Xavier
Halbaut, Lyda
Elmsmari, Firas
Pareja, Rubén
Arrien, Aizea
Duran-Sindreu, Fernando
Delgado, Luis María
Espina, Marta
García, María Luisa
Sánchez, José Antonio González
Sánchez-López, Elena
author Roig, Xavier
author_facet Roig, Xavier
Halbaut, Lyda
Elmsmari, Firas
Pareja, Rubén
Arrien, Aizea
Duran-Sindreu, Fernando
Delgado, Luis María
Espina, Marta
García, María Luisa
Sánchez, José Antonio González
Sánchez-López, Elena
author_role author
author2 Halbaut, Lyda
Elmsmari, Firas
Pareja, Rubén
Arrien, Aizea
Duran-Sindreu, Fernando
Delgado, Luis María
Espina, Marta
García, María Luisa
Sánchez, José Antonio González
Sánchez-López, Elena
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv 0000-0001-8684-835X
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Nanoparticles
PLGA
Calcium hydroxide
Endodontic
Gels
Intracanal medication
http://metadata.un.org/sdg/3
Ensure healthy lives and promote well-being for all at all ages
topic Nanoparticles
PLGA
Calcium hydroxide
Endodontic
Gels
Intracanal medication
http://metadata.un.org/sdg/3
Ensure healthy lives and promote well-being for all at all ages
description Design, produce and assess the viability of a novel nanotechnological antibacterial thermo-sensible intracanal medicament This involves encapsulating calcium hydroxide (Ca(OH)2 ) within polylactic-co-glycolic acid (PLGA) nanoparticles (NPs) and dispersing them in a thermosensitive gel (Ca(OH)2 -NPs-gel). In addition, perform in vitro and ex vivo assessments to evaluate tissue irritation and penetration capacity into dentinal tubules in comparison to free Ca(OH)2 .
publishDate 2024
dc.date.none.fl_str_mv 2024
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Postprint
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/349868
https://api.elsevier.com/content/abstract/scopus_id/85186223078
url http://hdl.handle.net/10261/349868
https://api.elsevier.com/content/abstract/scopus_id/85186223078
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv International endodontic journal
https://doi.org/10.1111/iej.14041
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Wiley-Blackwell
publisher.none.fl_str_mv Wiley-Blackwell
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869405654585704448
score 15,811543

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