Calcium hydroxide-loaded nanoparticles dispersed in thermosensitive gel as a novel intracanal medicament

Design, produce and assess the viability of a novel nanotechnological antibacterial thermo-sensible intracanal medicament This involves encapsulating calcium hydroxide (Ca(OH)2 ) within polylactic-co-glycolic acid (PLGA) nanoparticles (NPs) and dispersing them in a thermosensitive gel (Ca(OH)2 -NPs-...

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Detalles Bibliográficos
Autores: Roig, Xavier, Halbaut, Lyda, Elmsmari, Firas, Pareja, Rubén, Arrien, Aizea, Duran-Sindreu, Fernando, Delgado, Luis María, Espina, Marta, García, María Luisa, Sánchez, José Antonio González, Sánchez-López, Elena
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2024
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/349868
Acceso en línea:http://hdl.handle.net/10261/349868
https://api.elsevier.com/content/abstract/scopus_id/85186223078
Access Level:acceso abierto
Palabra clave:Nanoparticles
PLGA
Calcium hydroxide
Endodontic
Gels
Intracanal medication
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Descripción
Sumario:Design, produce and assess the viability of a novel nanotechnological antibacterial thermo-sensible intracanal medicament This involves encapsulating calcium hydroxide (Ca(OH)2 ) within polylactic-co-glycolic acid (PLGA) nanoparticles (NPs) and dispersing them in a thermosensitive gel (Ca(OH)2 -NPs-gel). In addition, perform in vitro and ex vivo assessments to evaluate tissue irritation and penetration capacity into dentinal tubules in comparison to free Ca(OH)2 .

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