Prognostic value of xenograft engraftment in patients with metastatic high-risk neuroblastoma

BackgroundSuccessful engraftment of human cancer biopsies in immunodeficient mice correlates with the poor prognosis of patients. This was reported 30 years ago for children with neuroblastoma, but the standard of care treatment evolved significantly during the last 15 years, leading to improved sur...

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Autores: Aschero R, Castillo-Ecija H, Baulenas-Farres M, Resa-Pares, C, Jimenez-Cabaco, A, Rodriguez, E, Monterrubio, C, Perez-Jaume, S, Suñol M, Chantada, GL, Lavarino, C, Mora, J, Carcaboso, AM
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Fundació Sant Joan de Déu
Repositorio:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
OAI Identifier:oai:fsjd.fundanetsuite.com:p23090
Acceso en línea:https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=23090
Access Level:acceso abierto
Palabra clave:engraftment
metastatic (stage M) high-risk neuroblastoma (HR-NB)
patient-derived xenograft (PDX)
prognosis
survival
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spelling Prognostic value of xenograft engraftment in patients with metastatic high-risk neuroblastomaAschero RCastillo-Ecija HBaulenas-Farres MResa-Pares, CJimenez-Cabaco, ARodriguez, EMonterrubio, CPerez-Jaume, SSuñol MChantada, GLLavarino, CMora, JCarcaboso, AMengraftmentmetastatic (stage M) high-risk neuroblastoma (HR-NB)patient-derived xenograft (PDX)prognosissurvivalBackgroundSuccessful engraftment of human cancer biopsies in immunodeficient mice correlates with the poor prognosis of patients. This was reported 30 years ago for children with neuroblastoma, but the standard of care treatment evolved significantly during the last 15 years, leading to improved survival of these patients. Here, we evaluated the association of patient-derived xenograft (PDX) engraftment and prognosis in patients receiving up-to-date treatments for cancers classified as metastatic (stage M) high-risk neuroblastoma (HR-NB) by the International Neuroblastoma Risk Group Staging System (INRGSS). MethodsWe obtained biopsies from patients with stage M HR-NB. We inoculated biopsy fragments subcutaneously in mice. We studied the association of PDX engraftment with event-free survival (EFS) and overall survival (OS) of patients. ResultsSince 2009, we established 17 PDX from 97 samples of 66 patients with stage M HR-NB, with a follow-up of at least two years. Factors associated with higher probability of engraftment were the death as outcome (p = .0006) and the amplification of the gene MYCN in tumors (p = .0271). Patients whose biopsies established a PDX had significantly shorter EFS and OS (p = .0039 and .0002, respectively) than patients whose samples did not engraft. The association of PDX engraftment and OS was significant in patients without MYCN amplification (p = .0041), but not in patients with MYCN amplification (p = .2707). ConclusionPositive PDX engraftment is a factor related to poor prognosis and fatal outcome in patients with stage M HR-NB treated with up-to-date therapies.WILEY2023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=23090PEDIATRIC BLOOD & CANCERISSN: 15455009ISSNe: 15455017reponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déuinstname:Fundació Sant Joan de DéuInglésinfo:eu-repo/semantics/openAccessoai:fsjd.fundanetsuite.com:p230902026-05-27T12:37:41Z
dc.title.none.fl_str_mv Prognostic value of xenograft engraftment in patients with metastatic high-risk neuroblastoma
title Prognostic value of xenograft engraftment in patients with metastatic high-risk neuroblastoma
spellingShingle Prognostic value of xenograft engraftment in patients with metastatic high-risk neuroblastoma
Aschero R
engraftment
metastatic (stage M) high-risk neuroblastoma (HR-NB)
patient-derived xenograft (PDX)
prognosis
survival
title_short Prognostic value of xenograft engraftment in patients with metastatic high-risk neuroblastoma
title_full Prognostic value of xenograft engraftment in patients with metastatic high-risk neuroblastoma
title_fullStr Prognostic value of xenograft engraftment in patients with metastatic high-risk neuroblastoma
title_full_unstemmed Prognostic value of xenograft engraftment in patients with metastatic high-risk neuroblastoma
title_sort Prognostic value of xenograft engraftment in patients with metastatic high-risk neuroblastoma
dc.creator.none.fl_str_mv Aschero R
Castillo-Ecija H
Baulenas-Farres M
Resa-Pares, C
Jimenez-Cabaco, A
Rodriguez, E
Monterrubio, C
Perez-Jaume, S
Suñol M
Chantada, GL
Lavarino, C
Mora, J
Carcaboso, AM
author Aschero R
author_facet Aschero R
Castillo-Ecija H
Baulenas-Farres M
Resa-Pares, C
Jimenez-Cabaco, A
Rodriguez, E
Monterrubio, C
Perez-Jaume, S
Suñol M
Chantada, GL
Lavarino, C
Mora, J
Carcaboso, AM
author_role author
author2 Castillo-Ecija H
Baulenas-Farres M
Resa-Pares, C
Jimenez-Cabaco, A
Rodriguez, E
Monterrubio, C
Perez-Jaume, S
Suñol M
Chantada, GL
Lavarino, C
Mora, J
Carcaboso, AM
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv engraftment
metastatic (stage M) high-risk neuroblastoma (HR-NB)
patient-derived xenograft (PDX)
prognosis
survival
topic engraftment
metastatic (stage M) high-risk neuroblastoma (HR-NB)
patient-derived xenograft (PDX)
prognosis
survival
description BackgroundSuccessful engraftment of human cancer biopsies in immunodeficient mice correlates with the poor prognosis of patients. This was reported 30 years ago for children with neuroblastoma, but the standard of care treatment evolved significantly during the last 15 years, leading to improved survival of these patients. Here, we evaluated the association of patient-derived xenograft (PDX) engraftment and prognosis in patients receiving up-to-date treatments for cancers classified as metastatic (stage M) high-risk neuroblastoma (HR-NB) by the International Neuroblastoma Risk Group Staging System (INRGSS). MethodsWe obtained biopsies from patients with stage M HR-NB. We inoculated biopsy fragments subcutaneously in mice. We studied the association of PDX engraftment with event-free survival (EFS) and overall survival (OS) of patients. ResultsSince 2009, we established 17 PDX from 97 samples of 66 patients with stage M HR-NB, with a follow-up of at least two years. Factors associated with higher probability of engraftment were the death as outcome (p = .0006) and the amplification of the gene MYCN in tumors (p = .0271). Patients whose biopsies established a PDX had significantly shorter EFS and OS (p = .0039 and .0002, respectively) than patients whose samples did not engraft. The association of PDX engraftment and OS was significant in patients without MYCN amplification (p = .0041), but not in patients with MYCN amplification (p = .2707). ConclusionPositive PDX engraftment is a factor related to poor prognosis and fatal outcome in patients with stage M HR-NB treated with up-to-date therapies.
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=23090
url https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=23090
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv WILEY
publisher.none.fl_str_mv WILEY
dc.source.none.fl_str_mv PEDIATRIC BLOOD & CANCER
ISSN: 15455009
ISSNe: 15455017
reponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
instname:Fundació Sant Joan de Déu
instname_str Fundació Sant Joan de Déu
reponame_str r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
collection r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812455

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