PAN-cancer analysis of S-phase enriched lncRNAs identifies oncogenic drivers and biomarkers

Despite improvement in our understanding of long noncoding RNAs (lncRNAs) role in cancer, efforts to find clinically relevant cancer-associated lncRNAs are still lacking. Here, using nascent RNA capture sequencing, we identify 1145 temporally expressed S-phase-enriched lncRNAs. Among these, 570 lncR...

Descripción completa

Detalles Bibliográficos
Autores: Ali, M.M. (Mohamad Moustafa)|||/items/b992c6c3-9a2f-4b75-b4c0-c46cb5a7b040, Akhade, V.S. (Vijay Suresh)|||/items/4e0f14d7-4129-4b1f-a9b3-a8cc43129628, Thankaswamy-Kosalai, S. (Subazini)|||/items/8330a760-78cc-413a-9ce1-f86f5da6888c, Subhash, S. (Santhilal)|||/items/3186ef0e-9627-463f-9da0-757cb140a4cb, Statello, L. (Luisa)|||/items/bd93ff38-fb37-46bd-9274-65da11af7f0f, Meryet-Figuiere, M. (Matthieu)|||/items/dfe0d84e-b8f5-4479-919e-78251ece22e8, Abrahamsson, J. (Jonas)|||/items/b25517f6-342c-498b-8c1b-156fc39603cb, Mondal, T. (Tanmoy)|||/items/d7593cfd-bc21-4d94-bf8a-92a1f073fa8c, Kanduri, C. (Chandrasekhar)|||/items/e10fe162-f146-47f5-a067-8335f2b99a62
Tipo de recurso: artículo
Fecha de publicación:2018
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:inglés
OAI Identifier:oai:dadun.unav.edu:10171/122273
Acceso en línea:https://hdl.handle.net/10171/122273
Access Level:acceso abierto
Palabra clave:long noncoding RNAs (lncRNAs)
SCAT7
patient-derived tumor (PDX) xenografts
Descripción
Sumario:Despite improvement in our understanding of long noncoding RNAs (lncRNAs) role in cancer, efforts to find clinically relevant cancer-associated lncRNAs are still lacking. Here, using nascent RNA capture sequencing, we identify 1145 temporally expressed S-phase-enriched lncRNAs. Among these, 570 lncRNAs show significant differential expression in at least one tumor type across TCGA data sets. Systematic clinical investigation of 14 Pan-Cancer data sets identified 633 independent prognostic markers. Silencing of the top differentially expressed and clinically relevant S-phase-enriched lncRNAs in several cancer models affects crucial cancer cell hallmarks. Mechanistic investigations on SCAT7 in multiple cancer types reveal that it interacts with hnRNPK/YBX1 complex and affects cancer cell hallmarks through the regulation of FGF/FGFR and its downstream PI3K/AKT and MAPK pathways. We also implement a LNA-antisense oligo-based strategy to treat cancer cell line and patient-derived tumor (PDX) xenografts. Thus, this study provides a comprehensive list of lncRNA-based oncogenic drivers with potential prognostic value.

Similares en LA Referencia