Urinary Cell Cycle Arrest Biomarkers and Diuretic Efficiency in Acute Heart Failure
Introduction: This study aimed to evaluate the association between the NephroCheck (R) test AKIRisk (R) score, diuretic efficiency (DE), and the odds of worsening kidney function (WKF) within the first 72 h of admission in patients hospitalized for acute heart failure (AHF). Methods: The study prosp...
| Autores: | , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2024 |
| País: | España |
| Institución: | INCLIVA |
| Repositorio: | r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA |
| OAI Identifier: | oai:incliva.fundanetsuite.com:p18330 |
| Acceso en línea: | https://incliva.portalinvestigacion.com/publicaciones/18330 |
| Access Level: | acceso abierto |
| Palabra clave: | Diuretic efficiency Acute heart failure Urinary [TIMP-2]x[IGFBP7] |
| Sumario: | Introduction: This study aimed to evaluate the association between the NephroCheck (R) test AKIRisk (R) score, diuretic efficiency (DE), and the odds of worsening kidney function (WKF) within the first 72 h of admission in patients hospitalized for acute heart failure (AHF). Methods: The study prospectively enrolled 125 patients admitted with AHF. NephroCheck (R) test was obtained within the first 24 h of admission. DE was defined as net fluid urine output per 40 mg of furosemide equivalents. Results: The median AKIRisk (R) score was 0.11 (IQR 0.06-0.34), and 38 (30.4%) patients had an AKIRisk (R) score >0.3. The median cumulative DE at 72 h was 1,963 mL (IQR 1317-3,239 mL). At 72 h, a total of 10 (8%) patients developed an absolute increase in sCr >= 0.5 mg/dL (WKF). In a multivariable setting, there was an inverse association between the AKIRisk (R) score and DE within the first 72 h. In fact, the highest the AKIRisk (R) score (centered at 0.3), the higher the likelihood of poor DE (below the median) and WKF at 72 h (odds ratio [OR] 2.04; 95%; CI: 1.02-4.07; p = 0.043, and OR 3.31, 95% CI: 1.30-8.43; p = 0.012, respectively). Conclusion: In patients with AHF, a higher NephroCheck (R) AKIRisk (R) score is associated with poorer DE and a higher risk of WKF at 72 h. Further research is needed to confirm the role of urinary cell cycle arrest biomarkers in the AHF scenario. |
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