Urinary Cell Cycle Arrest Biomarkers and Diuretic Efficiency in Acute Heart Failure

Introduction: This study aimed to evaluate the association between the NephroCheck® test AKIRisk® score, diuretic efficiency (DE), and the odds of worsening kidney function (WKF) within the first 72 h of admission in patients hospitalized for acute heart failure (AHF). Methods: The study prospective...

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Detalles Bibliográficos
Autores: Núñez-Marín, Gonzalo|||0000-0003-2867-5344, Romero-González, Gregorio|||0000-0001-7481-3678, Bover, Jordi|||0000-0003-3577-2273, Górriz, Jose Luis|||0000-0002-1134-9051, Bayés-Genís, Antoni|||0000-0002-3044-197X, Sanchis, Juan|||0000-0003-0797-8709, Núñez, Julio|||0000-0003-1672-7119, De la Espriella, Rafael|||0000-0002-8720-3999
Tipo de recurso: artículo
Fecha de publicación:2024
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:302194
Acceso en línea:https://ddd.uab.cat/record/302194
https://dx.doi.org/urn:doi:10.1159/000538774
Access Level:acceso abierto
Palabra clave:Diuretic efficiency
Acute heart failure
Urinary [TIMP-2]×[IGFBP7]
Descripción
Sumario:Introduction: This study aimed to evaluate the association between the NephroCheck® test AKIRisk® score, diuretic efficiency (DE), and the odds of worsening kidney function (WKF) within the first 72 h of admission in patients hospitalized for acute heart failure (AHF). Methods: The study prospectively enrolled 125 patients admitted with AHF. NephroCheck® test was obtained within the first 24 h of admission. DE was defined as net fluid urine output per 40 mg of furosemide equivalents. Results: The median AKIRisk® score was 0.11 (IQR 0.06-0.34), and 38 (30.4%) patients had an AKIRisk® score >0.3. The median cumulative DE at 72 h was 1,963 mL (IQR 1317-3,239 mL). At 72 h, a total of 10 (8%) patients developed an absolute increase in sCr =0.5 mg/dL (WKF). In a multivariable setting, there was an inverse association between the AKIRisk® score and DE within the first 72 h. In fact, the highest the AKIRisk® score (centered at 0.3), the higher the likelihood of poor DE (below the median) and WKF at 72 h (odds ratio [OR] 2.04; 95%; CI: 1.02-4.07; p = 0.043, and OR 3.31, 95% CI: 1.30-8.43; p = 0.012, respectively). Conclusion: In patients with AHF, a higher NephroCheck® AKIRisk® score is associated with poorer DE and a higher risk of WKF at 72 h. Further research is needed to confirm the role of urinary cell cycle arrest biomarkers in the AHF scenario.

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