APD, QT interval and Tx Values

This repository contains four Excel 2017 files named “APD.xlsx”, “QT.xlsx”, “Tx_APD.xlsx” and “Tx_QT.xlsx”. APD.xlsx and Tx_APD.xlsx files contain three sheets (called “Epi”, “Mid” and “Endo”), whereas the rest contain only one sheet (called “QT”). These files contain the results of simulations perf...

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Authors: Saiz Rodríguez, Francisco Javier|||0000-0002-9850-0825, Trenor Gomis, Beatriz Ana|||0000-0001-9166-6112, Gomis-Tena Dolz, Julio|||0000-0002-1309-2368, Romero Pérez, Lucia|||0000-0003-4605-8630, Sanz i Carreras, Ferran, Pastor Maeso, Manuel, Cano García, Jordi
Format: conjunto de datos
Publication Date:2017
Country:España
Institution:Universitat Politècnica de València (UPV)
Repository:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
Language:English
OAI Identifier:oai:riunet.upv.es:10251/90297
Online Access:https://riunet.upv.es/handle/10251/90297
Access Level:Open access
Keyword:QT prolongation
Drug-induced long-QT syndrome
QT
APD
MEDICINA
FARMACIA Y TECNOLOGIA FARMACEUTICA
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spelling APD, QT interval and Tx ValuesSaiz Rodríguez, Francisco Javier|||0000-0002-9850-0825Trenor Gomis, Beatriz Ana|||0000-0001-9166-6112Gomis-Tena Dolz, Julio|||0000-0002-1309-2368Romero Pérez, Lucia|||0000-0003-4605-8630Sanz i Carreras, FerranPastor Maeso, ManuelCano García, JordiQT prolongationDrug-induced long-QT syndromeQTAPDMEDICINAFARMACIA Y TECNOLOGIA FARMACEUTICAThis repository contains four Excel 2017 files named “APD.xlsx”, “QT.xlsx”, “Tx_APD.xlsx” and “Tx_QT.xlsx”. APD.xlsx and Tx_APD.xlsx files contain three sheets (called “Epi”, “Mid” and “Endo”), whereas the rest contain only one sheet (called “QT”). These files contain the results of simulations performed in the O’Hara-Rudy model (ORd) [1] of human ventricular cells (206.766 simulations) and tissue (7072 simulations), which consist of APD90 and QT intervals as well as a new index called Tx extracted from both APD and QT values. References: [1]. O’Hara, T.; Virág, L.; Varró, A.; Rudy, Y. Simulation of the Undiseased Human Cardiac Ventricular Action Potential: Model Formulation and Experimental Validation. PLoS Comput. Biol. 2011, 7 (5), e1002061. [2]. Romero L., Cano J., Gomis-Tena J., Trenor B., Sanz F., Pastor M., Saiz J. In silico QT and APD Prolongation Assay for Early Screening of Drug-Induced Proarrhythmic Risk. Journal of Chemical Information and Modeling. 2017 (Currently in revision).Universitat Politècnica de ValènciaDepartamento de Ingeniería ElectrónicaEscuela Técnica Superior de Ingeniería Aeroespacial y Diseño IndustrialEscuela Técnica Superior de Ingeniería IndustrialCentro de Investigación e Innovación en BioingenieríaEuropean CommissionGeneralitat ValencianaMinisterio de Economía y CompetitividadRepositorio Institucional de la Universitat Politècnica de València Riunet20172017-10-31datasethttp://purl.org/coar/resource_type/c_ddb1SMURhttp://purl.org/coar/version/c_71e4c1898caa6e32info:eu-repo/semantics/datasetapplication/pdfapplication/vnd.openxmlformats-officedocument.spreadsheetml.sheetapplication/vnd.openxmlformats-officedocument.spreadsheetml.sheetapplication/vnd.openxmlformats-officedocument.spreadsheetml.sheetapplication/vnd.openxmlformats-officedocument.spreadsheetml.sheethttps://riunet.upv.es/handle/10251/90297reponame:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valénciainstname:Universitat Politècnica de València (UPV)InglésengMinisterio de Economía y Competitividad http://dx.doi.org/10.13039/501100003329 DPI2015-69125-R SIMULACION COMPUTACIONAL PARA LA PREDICCION PERSONALIZADA DE LOS EFECTOS DE LOS FARMACOS SOBRE LA ACTIVIDAD CARDIACAGeneralitat Valenciana https://doi.org/10.13039/501100003359 PROMETEO%2F2016%2F088 MODELOS COMPUTACIONALES PERSONALIZADOS MULTI-ESCALA PARA LA OPTIMIZACION DEL DIAGNOSTICO Y TRATAMIENTO DE ARRITMIAS CARDIACAS (PERSONALISED DIGITAL HEART)European Commission https://doi.org/10.13039/501100000780 FP7 115002 Integrating bioinformatics and chemoinformatics approaches for the development of expert systems allowing the in silico prediction of toxicitiesopen accesshttp://purl.org/coar/access_right/c_abf2Reconocimiento - No comercial (by-nc) http://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessoai:riunet.upv.es:10251/902972026-06-13T07:49:27Z
dc.title.none.fl_str_mv APD, QT interval and Tx Values
title APD, QT interval and Tx Values
spellingShingle APD, QT interval and Tx Values
Saiz Rodríguez, Francisco Javier|||0000-0002-9850-0825
QT prolongation
Drug-induced long-QT syndrome
QT
APD
MEDICINA
FARMACIA Y TECNOLOGIA FARMACEUTICA
title_short APD, QT interval and Tx Values
title_full APD, QT interval and Tx Values
title_fullStr APD, QT interval and Tx Values
title_full_unstemmed APD, QT interval and Tx Values
title_sort APD, QT interval and Tx Values
dc.creator.none.fl_str_mv Saiz Rodríguez, Francisco Javier|||0000-0002-9850-0825
Trenor Gomis, Beatriz Ana|||0000-0001-9166-6112
Gomis-Tena Dolz, Julio|||0000-0002-1309-2368
Romero Pérez, Lucia|||0000-0003-4605-8630
Sanz i Carreras, Ferran
Pastor Maeso, Manuel
Cano García, Jordi
author Saiz Rodríguez, Francisco Javier|||0000-0002-9850-0825
author_facet Saiz Rodríguez, Francisco Javier|||0000-0002-9850-0825
Trenor Gomis, Beatriz Ana|||0000-0001-9166-6112
Gomis-Tena Dolz, Julio|||0000-0002-1309-2368
Romero Pérez, Lucia|||0000-0003-4605-8630
Sanz i Carreras, Ferran
Pastor Maeso, Manuel
Cano García, Jordi
author_role author
author2 Trenor Gomis, Beatriz Ana|||0000-0001-9166-6112
Gomis-Tena Dolz, Julio|||0000-0002-1309-2368
Romero Pérez, Lucia|||0000-0003-4605-8630
Sanz i Carreras, Ferran
Pastor Maeso, Manuel
Cano García, Jordi
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Departamento de Ingeniería Electrónica
Escuela Técnica Superior de Ingeniería Aeroespacial y Diseño Industrial
Escuela Técnica Superior de Ingeniería Industrial
Centro de Investigación e Innovación en Bioingeniería
European Commission
Generalitat Valenciana
Ministerio de Economía y Competitividad
Repositorio Institucional de la Universitat Politècnica de València Riunet
dc.subject.none.fl_str_mv QT prolongation
Drug-induced long-QT syndrome
QT
APD
MEDICINA
FARMACIA Y TECNOLOGIA FARMACEUTICA
topic QT prolongation
Drug-induced long-QT syndrome
QT
APD
MEDICINA
FARMACIA Y TECNOLOGIA FARMACEUTICA
description This repository contains four Excel 2017 files named “APD.xlsx”, “QT.xlsx”, “Tx_APD.xlsx” and “Tx_QT.xlsx”. APD.xlsx and Tx_APD.xlsx files contain three sheets (called “Epi”, “Mid” and “Endo”), whereas the rest contain only one sheet (called “QT”). These files contain the results of simulations performed in the O’Hara-Rudy model (ORd) [1] of human ventricular cells (206.766 simulations) and tissue (7072 simulations), which consist of APD90 and QT intervals as well as a new index called Tx extracted from both APD and QT values. References: [1]. O’Hara, T.; Virág, L.; Varró, A.; Rudy, Y. Simulation of the Undiseased Human Cardiac Ventricular Action Potential: Model Formulation and Experimental Validation. PLoS Comput. Biol. 2011, 7 (5), e1002061. [2]. Romero L., Cano J., Gomis-Tena J., Trenor B., Sanz F., Pastor M., Saiz J. In silico QT and APD Prolongation Assay for Early Screening of Drug-Induced Proarrhythmic Risk. Journal of Chemical Information and Modeling. 2017 (Currently in revision).
publishDate 2017
dc.date.none.fl_str_mv 2017
2017-10-31
dc.type.none.fl_str_mv dataset
http://purl.org/coar/resource_type/c_ddb1
SMUR
http://purl.org/coar/version/c_71e4c1898caa6e32
dc.type.openaire.fl_str_mv info:eu-repo/semantics/dataset
format dataset
dc.identifier.none.fl_str_mv https://riunet.upv.es/handle/10251/90297
url https://riunet.upv.es/handle/10251/90297
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Ministerio de Economía y Competitividad http://dx.doi.org/10.13039/501100003329 DPI2015-69125-R SIMULACION COMPUTACIONAL PARA LA PREDICCION PERSONALIZADA DE LOS EFECTOS DE LOS FARMACOS SOBRE LA ACTIVIDAD CARDIACA
Generalitat Valenciana https://doi.org/10.13039/501100003359 PROMETEO%2F2016%2F088 MODELOS COMPUTACIONALES PERSONALIZADOS MULTI-ESCALA PARA LA OPTIMIZACION DEL DIAGNOSTICO Y TRATAMIENTO DE ARRITMIAS CARDIACAS (PERSONALISED DIGITAL HEART)
European Commission https://doi.org/10.13039/501100000780 FP7 115002 Integrating bioinformatics and chemoinformatics approaches for the development of expert systems allowing the in silico prediction of toxicities
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Reconocimiento - No comercial (by-nc)
http://creativecommons.org/licenses/by-nc/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Reconocimiento - No comercial (by-nc)
http://creativecommons.org/licenses/by-nc/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/vnd.openxmlformats-officedocument.spreadsheetml.sheet
application/vnd.openxmlformats-officedocument.spreadsheetml.sheet
application/vnd.openxmlformats-officedocument.spreadsheetml.sheet
application/vnd.openxmlformats-officedocument.spreadsheetml.sheet
dc.publisher.none.fl_str_mv Universitat Politècnica de València
publisher.none.fl_str_mv Universitat Politècnica de València
dc.source.none.fl_str_mv reponame:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
instname:Universitat Politècnica de València (UPV)
instname_str Universitat Politècnica de València (UPV)
reponame_str RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
collection RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869405543694598144
score 15,811543

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