APD, QT interval and Tx Values
This repository contains four Excel 2017 files named “APD.xlsx”, “QT.xlsx”, “Tx_APD.xlsx” and “Tx_QT.xlsx”. APD.xlsx and Tx_APD.xlsx files contain three sheets (called “Epi”, “Mid” and “Endo”), whereas the rest contain only one sheet (called “QT”). These files contain the results of simulations perf...
| Autores: | , , , , , , |
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| Tipo de recurso: | conjunto de datos |
| Fecha de publicación: | 2017 |
| País: | España |
| Institución: | Universitat Politècnica de València (UPV) |
| Repositorio: | RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia |
| Idioma: | inglés |
| OAI Identifier: | oai:riunet.upv.es:10251/90297 |
| Acceso en línea: | https://riunet.upv.es/handle/10251/90297 |
| Access Level: | acceso abierto |
| Palabra clave: | QT prolongation Drug-induced long-QT syndrome QT APD MEDICINA FARMACIA Y TECNOLOGIA FARMACEUTICA |
| Sumario: | This repository contains four Excel 2017 files named “APD.xlsx”, “QT.xlsx”, “Tx_APD.xlsx” and “Tx_QT.xlsx”. APD.xlsx and Tx_APD.xlsx files contain three sheets (called “Epi”, “Mid” and “Endo”), whereas the rest contain only one sheet (called “QT”). These files contain the results of simulations performed in the O’Hara-Rudy model (ORd) [1] of human ventricular cells (206.766 simulations) and tissue (7072 simulations), which consist of APD90 and QT intervals as well as a new index called Tx extracted from both APD and QT values. References: [1]. O’Hara, T.; Virág, L.; Varró, A.; Rudy, Y. Simulation of the Undiseased Human Cardiac Ventricular Action Potential: Model Formulation and Experimental Validation. PLoS Comput. Biol. 2011, 7 (5), e1002061. [2]. Romero L., Cano J., Gomis-Tena J., Trenor B., Sanz F., Pastor M., Saiz J. In silico QT and APD Prolongation Assay for Early Screening of Drug-Induced Proarrhythmic Risk. Journal of Chemical Information and Modeling. 2017 (Currently in revision). |
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