Performance of QuantiFERON-TB Gold Plus assays in paediatric tuberculosis: a multicentre PTBNET study

Rationale In 2016, a new interferon-gamma release assay (IGRA) was introduced, QuantiFERON-TB Gold Plus (QFT-Plus), claimed to have improved sensitivity in active tuberculosis (TB). Objectives This study aimed to determine the performance of QFT-Plus, compared with previous generation IGRAs and the...

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Autores: Buonsenso D, Noguera-Julian A, Moroni R, Hernández-Bartolomé A, Fritschi N, Lancella L, Cursi L, Soler-Garcia A, Krüger R, Feiterna-Sperling C, Sali M, Lo Vecchio A, Scarano S, Hernanz Lobo A, Espiau M, Soriano-Arandes A, Cetin BS, Brinkmann F, Ozere I, Baquero-Artigao F, Tsolia M, Milheiro Silva T, Bustillo-Alonso M, Martín Nalda A, Mancini M, Starshinova A, Ritz N, Velizarova S, Ferreras-Antolín L, Götzinger F, Bilogortseva O, Chechenyeva V, Tebruegge M, Santiago-García B
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Fundació Sant Joan de Déu
Repositorio:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
OAI Identifier:oai:fsjd.fundanetsuite.com:p22318
Acceso en línea:https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=22318
Access Level:acceso abierto
Palabra clave:Tuberculosis
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spelling Performance of QuantiFERON-TB Gold Plus assays in paediatric tuberculosis: a multicentre PTBNET studyBuonsenso DNoguera-Julian AMoroni RHernández-Bartolomé AFritschi NLancella LCursi LSoler-Garcia AKrüger RFeiterna-Sperling CSali MLo Vecchio AScarano SHernanz Lobo AEspiau MSoriano-Arandes ACetin BSBrinkmann FOzere IBaquero-Artigao FTsolia MMilheiro Silva TBustillo-Alonso MMartín Nalda AMancini MStarshinova ARitz NVelizarova SFerreras-Antolín LGötzinger FBilogortseva OChechenyeva VTebruegge MSantiago-García BTuberculosisRationale In 2016, a new interferon-gamma release assay (IGRA) was introduced, QuantiFERON-TB Gold Plus (QFT-Plus), claimed to have improved sensitivity in active tuberculosis (TB). Objectives This study aimed to determine the performance of QFT-Plus, compared with previous generation IGRAs and the tuberculin skin test (TST), in children with TB in Europe. Methods Multicentre, ambispective cohort study within the Paediatric Tuberculosis Network European Trials Group (ptbnet), a dedicated paediatric TB research network comprising >300 members, capturing TB cases Measurements and main results 1001 TB cases from 16 countries were included (mean age (IQR) 5.6 (2.4-12.1) years). QFT-Plus was performed in 358, QFT Gold in-Tube (QFT-GIT) in 600, T-SPOT.TB in 58 and TST in 636 cases. The overall test sensitivities were: QFT-Plus 83.8% (95% CI 80.2% to 87.8%), QFT-GIT 85.5% (95% CI 82.7% to 88.3%), T-SPOT.TB 77.6% (95% CI 66.9% to 88.3%) and TST (cut-off >= 10 mm) 83.3% (95% CI 83.3% to 86.2%). There was a trend for tests to have lower sensitivity in patients with miliary and/or central nervous system (CNS) TB (73.1%, 70.9%, 63.6% and 43.5%, respectively), and in immunocompromised patients (75.0%, 59.6%, 45.5% and 59.1%, respectively). Conclusions The results indicate that the latest generation IGRA assay, QFT-Plus, does not perform better than previous generation IGRAs or the TST in children with TB disease. Overall, tests performed worse in CNS and miliary TB, and in immunocompromised children. None of the tests evaluated had sufficiently high sensitivity to be used as a rule-out test in children with suspected TB.BMJ PUBLISHING GROUP2023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=22318THORAXISSN: 00406376ISSNe: 14683296reponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déuinstname:Fundació Sant Joan de DéuInglésinfo:eu-repo/semantics/openAccessoai:fsjd.fundanetsuite.com:p223182026-05-27T12:37:41Z
dc.title.none.fl_str_mv Performance of QuantiFERON-TB Gold Plus assays in paediatric tuberculosis: a multicentre PTBNET study
title Performance of QuantiFERON-TB Gold Plus assays in paediatric tuberculosis: a multicentre PTBNET study
spellingShingle Performance of QuantiFERON-TB Gold Plus assays in paediatric tuberculosis: a multicentre PTBNET study
Buonsenso D
Tuberculosis
title_short Performance of QuantiFERON-TB Gold Plus assays in paediatric tuberculosis: a multicentre PTBNET study
title_full Performance of QuantiFERON-TB Gold Plus assays in paediatric tuberculosis: a multicentre PTBNET study
title_fullStr Performance of QuantiFERON-TB Gold Plus assays in paediatric tuberculosis: a multicentre PTBNET study
title_full_unstemmed Performance of QuantiFERON-TB Gold Plus assays in paediatric tuberculosis: a multicentre PTBNET study
title_sort Performance of QuantiFERON-TB Gold Plus assays in paediatric tuberculosis: a multicentre PTBNET study
dc.creator.none.fl_str_mv Buonsenso D
Noguera-Julian A
Moroni R
Hernández-Bartolomé A
Fritschi N
Lancella L
Cursi L
Soler-Garcia A
Krüger R
Feiterna-Sperling C
Sali M
Lo Vecchio A
Scarano S
Hernanz Lobo A
Espiau M
Soriano-Arandes A
Cetin BS
Brinkmann F
Ozere I
Baquero-Artigao F
Tsolia M
Milheiro Silva T
Bustillo-Alonso M
Martín Nalda A
Mancini M
Starshinova A
Ritz N
Velizarova S
Ferreras-Antolín L
Götzinger F
Bilogortseva O
Chechenyeva V
Tebruegge M
Santiago-García B
author Buonsenso D
author_facet Buonsenso D
Noguera-Julian A
Moroni R
Hernández-Bartolomé A
Fritschi N
Lancella L
Cursi L
Soler-Garcia A
Krüger R
Feiterna-Sperling C
Sali M
Lo Vecchio A
Scarano S
Hernanz Lobo A
Espiau M
Soriano-Arandes A
Cetin BS
Brinkmann F
Ozere I
Baquero-Artigao F
Tsolia M
Milheiro Silva T
Bustillo-Alonso M
Martín Nalda A
Mancini M
Starshinova A
Ritz N
Velizarova S
Ferreras-Antolín L
Götzinger F
Bilogortseva O
Chechenyeva V
Tebruegge M
Santiago-García B
author_role author
author2 Noguera-Julian A
Moroni R
Hernández-Bartolomé A
Fritschi N
Lancella L
Cursi L
Soler-Garcia A
Krüger R
Feiterna-Sperling C
Sali M
Lo Vecchio A
Scarano S
Hernanz Lobo A
Espiau M
Soriano-Arandes A
Cetin BS
Brinkmann F
Ozere I
Baquero-Artigao F
Tsolia M
Milheiro Silva T
Bustillo-Alonso M
Martín Nalda A
Mancini M
Starshinova A
Ritz N
Velizarova S
Ferreras-Antolín L
Götzinger F
Bilogortseva O
Chechenyeva V
Tebruegge M
Santiago-García B
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Tuberculosis
topic Tuberculosis
description Rationale In 2016, a new interferon-gamma release assay (IGRA) was introduced, QuantiFERON-TB Gold Plus (QFT-Plus), claimed to have improved sensitivity in active tuberculosis (TB). Objectives This study aimed to determine the performance of QFT-Plus, compared with previous generation IGRAs and the tuberculin skin test (TST), in children with TB in Europe. Methods Multicentre, ambispective cohort study within the Paediatric Tuberculosis Network European Trials Group (ptbnet), a dedicated paediatric TB research network comprising >300 members, capturing TB cases Measurements and main results 1001 TB cases from 16 countries were included (mean age (IQR) 5.6 (2.4-12.1) years). QFT-Plus was performed in 358, QFT Gold in-Tube (QFT-GIT) in 600, T-SPOT.TB in 58 and TST in 636 cases. The overall test sensitivities were: QFT-Plus 83.8% (95% CI 80.2% to 87.8%), QFT-GIT 85.5% (95% CI 82.7% to 88.3%), T-SPOT.TB 77.6% (95% CI 66.9% to 88.3%) and TST (cut-off >= 10 mm) 83.3% (95% CI 83.3% to 86.2%). There was a trend for tests to have lower sensitivity in patients with miliary and/or central nervous system (CNS) TB (73.1%, 70.9%, 63.6% and 43.5%, respectively), and in immunocompromised patients (75.0%, 59.6%, 45.5% and 59.1%, respectively). Conclusions The results indicate that the latest generation IGRA assay, QFT-Plus, does not perform better than previous generation IGRAs or the TST in children with TB disease. Overall, tests performed worse in CNS and miliary TB, and in immunocompromised children. None of the tests evaluated had sufficiently high sensitivity to be used as a rule-out test in children with suspected TB.
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=22318
url https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=22318
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv BMJ PUBLISHING GROUP
publisher.none.fl_str_mv BMJ PUBLISHING GROUP
dc.source.none.fl_str_mv THORAX
ISSN: 00406376
ISSNe: 14683296
reponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
instname:Fundació Sant Joan de Déu
instname_str Fundació Sant Joan de Déu
reponame_str r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
collection r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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