Reversions of QuantiFERON-TB Gold Plus in tuberculosis contact investigation: A prospective multicentre cohort study

Background: Interferon-y Release Assays (IGRA) reversions have been reported in different clinical scenarios for the diagnosis of tuberculosis (TB) infection. This study aimed to determine the rate of QuantiFERON-TB Gold Plus (QFT-Plus) reversions during contact investigation as a potential strategy...

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Detalles Bibliográficos
Autores: García Gasalla, Mercedes, Pérez-Recio, Sandra, Grijota Camino, Mª de los Desamparados, Anibarro, Luis, Rabuñal Rey, Ramón, Sabrià, Josefina, Gijón-Vidaurreta, Paloma, Pomar, Virginia, Domínguez-Castellano, Ángel, Trigo, Matilde, Santos, María Jesús, Cebollero, Alba, Rodríguez, Sara, Moga, Esther, Penas-Truque, Anton, Martos, Carmen, Ruiz-Serrano, María J., García de Cara, Erika Inés, Alcaide Fernández de Vega, Fernando, Santín Cerezales, Miguel
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/208412
Acceso en línea:https://hdl.handle.net/2445/208412
Access Level:acceso abierto
Palabra clave:Tuberculosi
Medicina preventiva
Adults
Tuberculosis
Preventive medicine
Adulthood
Descripción
Sumario:Background: Interferon-y Release Assays (IGRA) reversions have been reported in different clinical scenarios for the diagnosis of tuberculosis (TB) infection. This study aimed to determine the rate of QuantiFERON-TB Gold Plus (QFT-Plus) reversions during contact investigation as a potential strategy to reduce the number of preventive treatments. Methods: Prospective, multicentre cohort study of immunocompetent adult contacts of patients with pulmonary TB tested with QFT-Plus. Contacts with an initial positive QFT-Plus (QFT-i) underwent a second test within 4 weeks (QFT-1), and if negative, underwent a repeat test 4 weeks later (QFT-2). Based on the QFT-2 result, we classified cases as sustained reversion if they remained negative and as temporary reversion if they turned positive. Results: We included 415 contacts, of whom 96 (23.1%) had an initial positive test (QFT-i). Following this, 10 had negative QFT-1 results and 4 (4.2%) of these persisted with a negative result in the QFT-2 (sustained reversions). All four sustained reversions occurred in contacts with IFN-γ concentrations between ≥0.35 and ≤0.99 IU•mL-1 in one or both QFT-i tubes. Conclusion: In this study, TB contact investigations rarely reveal QFT-Plus reversion. These results do not support retesting cases with an initial positive result to reduce the number of preventive treatments.

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