Clinical epidemiology and molecular biology of cutaneous and mucosal melanoma in Girona 1994-2018

In this doctoral thesis, the epidemiology of cutaneous and mucosal melanoma is analyzed, as well as its molecular profile to provide new knowledge on a population basis in the province of Girona. The cancer registry of Girona was used as a high reliable a source of cases. The incidence and overall/r...

Descripción completa

Detalles Bibliográficos
Autor: Carbó Bagué, Anna
Tipo de recurso: tesis doctoral
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:CBUC, CESCA
Repositorio:TDR. Tesis Doctorales en Red
OAI Identifier:oai:www.tdx.cat:10803/688699
Acceso en línea:http://hdl.handle.net/10803/688699
Access Level:acceso abierto
Palabra clave:Melanoma
Epidemiologia descriptiva
Epidemiología descriptiva
Desrciptive epidemiology
Biologia molecular
Biología molecular
Molecular biology
Càncer
Cáncer
Cancer
Incidència
Incidencia
Incidence
Supervivència
Supervivencia
Survival
Girona
Genètica
Genética
Genetics
311
575
577
616
id ES_2ff6ec32bb87b661efd2ece8362d3085
oai_identifier_str oai:www.tdx.cat:10803/688699
network_acronym_str ES
network_name_str España
repository_id_str
spelling Clinical epidemiology and molecular biology of cutaneous and mucosal melanoma in Girona 1994-2018Carbó Bagué, AnnaMelanomaEpidemiologia descriptivaEpidemiología descriptivaDesrciptive epidemiologyBiologia molecularBiología molecularMolecular biologyCàncerCáncerCancerIncidènciaIncidenciaIncidenceSupervivènciaSupervivenciaSurvivalGironaGenèticaGenéticaGenetics311575577616In this doctoral thesis, the epidemiology of cutaneous and mucosal melanoma is analyzed, as well as its molecular profile to provide new knowledge on a population basis in the province of Girona. The cancer registry of Girona was used as a high reliable a source of cases. The incidence and overall/relative survival at 5 and 10 years are described, in addition, a molecular analysis of the BRAF gene in cutaneous melanoma and a genetic panel in mucosal melanoma is performed. In addition, medical evidence is provided for the treatment of patients in daily clinical practice. Overall survival at 5 years for all stages in cutaneous melanomas is 81% similar to other published studies with a prevalence of mutations in the BRAF gene around 50% and stage being the only statistically significant prognostic factor for the survival. It is confirmed that BRAF gene mutation is not a prognostic factor. 5-year overall survival for all stages in mucosal melanomas is around 21%, also similar to other published studies. Vulvo-vaginal melanomas have better survival. The molecular profile where mutations in NRAS and NF1 dominate is different from cutaneous melanoma and we corroborate that they have a clearly worse prognosisEn aquesta tesi doctoral s’analitza l’epidemiologia del melanoma cutani i de mucoses, així com el seu perfil molecular per aportar nous coneixements en base poblacional de la província de Girona. Com a font de casos s’ha utilitzat el registre de càncer de Girona. Es descriu la incidència i la supervivència global i relativa a 5 i 10 anys, a més a més, es fa un anàlisi molecular del gen BRAF en el melanoma cutani i un panell genètic en el melanoma de mucoses. A part, s’aporta evidència mèdica del tractament dels pacients a la pràctica clínica diària. La supervivència global a 5 anys per tots els estadis en els melanomes cutanis és del 81% similar als altres estudis publicats amb una prevalença de mutacions en el gen BRAF al voltant del 50% i essent l’estadi l’únic factor pronòstic estadísticament significatiu per la supervivència. Es confirma que la mutació del gen BRAF no és un factor pronòstic. La supervivència global a 5 anys per tots els estadis en els melanomes de mucoses és del 21% similar també als altres estudis publicats. Els vulvo-vaginals són els que tenen millor supervivència. El perfil molecular on dominen les mutacions a NRAS i NF1 és diferent al melanoma cutani i es corrobora que tenen un clar pitjor pronòsticPrograma de Doctorat en Biologia Molecular, Biomedicina i SalutUniversitat de GironaMarcos-Gragera, RafaelRubió i Casadevall, JordiSáez Zafra, MarcUniversitat de Girona. Departament d'InfermeriaUniversitat de Girona. Departament de Ciències MèdiquesUniversitat de Girona. Departament d'Economia202320232023info:eu-repo/semantics/doctoralThesisinfo:eu-repo/semantics/publishedVersion78 p.application/pdfhttp://hdl.handle.net/10803/688699TDX (Tesis Doctorals en Xarxa)reponame:TDR. Tesis Doctorales en Redinstname:CBUC, CESCAInglésL'accés als continguts d'aquesta tesi queda condicionat a l'acceptació de les condicions d'ús establertes per la següent llicència Creative Commons: http://creativecommons.org/licenses/by-nc/4.0/http://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessoai:www.tdx.cat:10803/6886992026-06-14T12:46:07Z
dc.title.none.fl_str_mv Clinical epidemiology and molecular biology of cutaneous and mucosal melanoma in Girona 1994-2018
title Clinical epidemiology and molecular biology of cutaneous and mucosal melanoma in Girona 1994-2018
spellingShingle Clinical epidemiology and molecular biology of cutaneous and mucosal melanoma in Girona 1994-2018
Carbó Bagué, Anna
Melanoma
Epidemiologia descriptiva
Epidemiología descriptiva
Desrciptive epidemiology
Biologia molecular
Biología molecular
Molecular biology
Càncer
Cáncer
Cancer
Incidència
Incidencia
Incidence
Supervivència
Supervivencia
Survival
Girona
Genètica
Genética
Genetics
311
575
577
616
title_short Clinical epidemiology and molecular biology of cutaneous and mucosal melanoma in Girona 1994-2018
title_full Clinical epidemiology and molecular biology of cutaneous and mucosal melanoma in Girona 1994-2018
title_fullStr Clinical epidemiology and molecular biology of cutaneous and mucosal melanoma in Girona 1994-2018
title_full_unstemmed Clinical epidemiology and molecular biology of cutaneous and mucosal melanoma in Girona 1994-2018
title_sort Clinical epidemiology and molecular biology of cutaneous and mucosal melanoma in Girona 1994-2018
dc.creator.none.fl_str_mv Carbó Bagué, Anna
author Carbó Bagué, Anna
author_facet Carbó Bagué, Anna
author_role author
dc.contributor.none.fl_str_mv Marcos-Gragera, Rafael
Rubió i Casadevall, Jordi
Sáez Zafra, Marc
Universitat de Girona. Departament d'Infermeria
Universitat de Girona. Departament de Ciències Mèdiques
Universitat de Girona. Departament d'Economia
dc.subject.none.fl_str_mv Melanoma
Epidemiologia descriptiva
Epidemiología descriptiva
Desrciptive epidemiology
Biologia molecular
Biología molecular
Molecular biology
Càncer
Cáncer
Cancer
Incidència
Incidencia
Incidence
Supervivència
Supervivencia
Survival
Girona
Genètica
Genética
Genetics
311
575
577
616
topic Melanoma
Epidemiologia descriptiva
Epidemiología descriptiva
Desrciptive epidemiology
Biologia molecular
Biología molecular
Molecular biology
Càncer
Cáncer
Cancer
Incidència
Incidencia
Incidence
Supervivència
Supervivencia
Survival
Girona
Genètica
Genética
Genetics
311
575
577
616
description In this doctoral thesis, the epidemiology of cutaneous and mucosal melanoma is analyzed, as well as its molecular profile to provide new knowledge on a population basis in the province of Girona. The cancer registry of Girona was used as a high reliable a source of cases. The incidence and overall/relative survival at 5 and 10 years are described, in addition, a molecular analysis of the BRAF gene in cutaneous melanoma and a genetic panel in mucosal melanoma is performed. In addition, medical evidence is provided for the treatment of patients in daily clinical practice. Overall survival at 5 years for all stages in cutaneous melanomas is 81% similar to other published studies with a prevalence of mutations in the BRAF gene around 50% and stage being the only statistically significant prognostic factor for the survival. It is confirmed that BRAF gene mutation is not a prognostic factor. 5-year overall survival for all stages in mucosal melanomas is around 21%, also similar to other published studies. Vulvo-vaginal melanomas have better survival. The molecular profile where mutations in NRAS and NF1 dominate is different from cutaneous melanoma and we corroborate that they have a clearly worse prognosis
publishDate 2023
dc.date.none.fl_str_mv 2023
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/doctoralThesis
info:eu-repo/semantics/publishedVersion
format doctoralThesis
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10803/688699
url http://hdl.handle.net/10803/688699
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by-nc/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 78 p.
application/pdf
dc.publisher.none.fl_str_mv Universitat de Girona
publisher.none.fl_str_mv Universitat de Girona
dc.source.none.fl_str_mv TDX (Tesis Doctorals en Xarxa)
reponame:TDR. Tesis Doctorales en Red
instname:CBUC, CESCA
instname_str CBUC, CESCA
reponame_str TDR. Tesis Doctorales en Red
collection TDR. Tesis Doctorales en Red
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869405513209348096
score 15,301603

Similares en LA Referencia