Targeting the Tumor Microenvironment in Breast Cancer: Prognostic and Predictive Significance and Therapeutic Opportunities

© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

Detalles Bibliográficos
Autores: Domínguez-Cejudo, María A., Gil-Torralvo, Ana, Cejuela, Mónica, Molina-Pinelo, Sonia, Salvador-Bofill, Javier
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/353719
Acceso en línea:http://hdl.handle.net/10261/353719
Access Level:acceso abierto
Palabra clave:Breast cancer
Tumor microenvironment
Biomarkers
Targeted therapy
id ES_2fea0dcc19f1f6f3f7f33cbb1087918d
oai_identifier_str oai:digital.csic.es:10261/353719
network_acronym_str ES
network_name_str España
repository_id_str
spelling Targeting the Tumor Microenvironment in Breast Cancer: Prognostic and Predictive Significance and Therapeutic OpportunitiesDomínguez-Cejudo, María A.Gil-Torralvo, AnaCejuela, MónicaMolina-Pinelo, SoniaSalvador-Bofill, JavierBreast cancerTumor microenvironmentBiomarkersTargeted therapy© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).Breast cancer is one of the most prevalent tumors among women. Its prognosis and treatment outcomes depend on factors related to tumor cell biology. However, recent studies have revealed the critical role of the tumor microenvironment (TME) in the development, progression, and treatment response of breast cancer. In this review, we explore the different components of the TME and their relevance as prognostic and predictive biomarkers in breast cancer. In addition, techniques for assessing the tumor microenvironment, such as immunohistochemistry or gene expression profiling, and their clinical utility in therapeutic decision-making are examined. Finally, therapeutic strategies targeting the TME are reviewed, highlighting their potential clinical benefits. Overall, this review emphasizes the importance of the TME in breast cancer and its potential as a clinical tool for better patient stratification and the design of personalized therapies.This research received no external funding, but the authors acknowledge support from the Andalusia-Roche Network Mixed Alliance in Precision Medical Oncology through resources composed of a financial contribution from the Andalusian Public Health System through a grant entitled “Alianza Mixta en Red Andalucía-Roche en Oncología Médica de Precisión (Investigación Básica/Traslacional)” financed by the Regional Ministry of Health and Families (PIP-0044-2020) through a competitive public call for proposals and by Roche Farma S.A. with private funds. A.G.-T. and S.M.-P. received funding from the Regional Ministry of Health and Families (RB-0003-2019 and RC-0004-2020, respectively)Peer reviewedMultidisciplinary Digital Publishing InstituteServicio Andaluz de SaludJunta de AndalucíaRocheConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202420242023info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_dcae04bcPublisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/353719reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttps://doi.org/10.3390/ijms242316771Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3537192026-05-22T06:33:51Z
dc.title.none.fl_str_mv Targeting the Tumor Microenvironment in Breast Cancer: Prognostic and Predictive Significance and Therapeutic Opportunities
title Targeting the Tumor Microenvironment in Breast Cancer: Prognostic and Predictive Significance and Therapeutic Opportunities
spellingShingle Targeting the Tumor Microenvironment in Breast Cancer: Prognostic and Predictive Significance and Therapeutic Opportunities
Domínguez-Cejudo, María A.
Breast cancer
Tumor microenvironment
Biomarkers
Targeted therapy
title_short Targeting the Tumor Microenvironment in Breast Cancer: Prognostic and Predictive Significance and Therapeutic Opportunities
title_full Targeting the Tumor Microenvironment in Breast Cancer: Prognostic and Predictive Significance and Therapeutic Opportunities
title_fullStr Targeting the Tumor Microenvironment in Breast Cancer: Prognostic and Predictive Significance and Therapeutic Opportunities
title_full_unstemmed Targeting the Tumor Microenvironment in Breast Cancer: Prognostic and Predictive Significance and Therapeutic Opportunities
title_sort Targeting the Tumor Microenvironment in Breast Cancer: Prognostic and Predictive Significance and Therapeutic Opportunities
dc.creator.none.fl_str_mv Domínguez-Cejudo, María A.
Gil-Torralvo, Ana
Cejuela, Mónica
Molina-Pinelo, Sonia
Salvador-Bofill, Javier
author Domínguez-Cejudo, María A.
author_facet Domínguez-Cejudo, María A.
Gil-Torralvo, Ana
Cejuela, Mónica
Molina-Pinelo, Sonia
Salvador-Bofill, Javier
author_role author
author2 Gil-Torralvo, Ana
Cejuela, Mónica
Molina-Pinelo, Sonia
Salvador-Bofill, Javier
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Servicio Andaluz de Salud
Junta de Andalucía
Roche
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Breast cancer
Tumor microenvironment
Biomarkers
Targeted therapy
topic Breast cancer
Tumor microenvironment
Biomarkers
Targeted therapy
description © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
publishDate 2023
dc.date.none.fl_str_mv 2023
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_dcae04bc
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/353719
url http://hdl.handle.net/10261/353719
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://doi.org/10.3390/ijms242316771
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869405509961908224
score 15,812429

Similares en LA Referencia