Immunological characteristics of the tumor microenvironment of breast cancer and their utilization as prognostic factor and treatment: a review / Características imunológicas do microambiente tumoral do câncer de mama e sua utilização como fator prognóstico e tratamento: uma revisão
Globally, breast cancer is the most diagnosed neoplasm in women. In some countries, it’s consolidated as the type of neoplasm that causes the most deaths, being responsible for premature deaths. The molecular classification of cancer allows specific treatment for each patient; however, some types ha...
| Autores: | , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2021 |
| País: | Brasil |
| Institución: | Instituto Superior de Educação Vera Cruz (VeraCruz) |
| Repositorio: | Revista Veras |
| Idioma: | inglés |
| OAI Identifier: | oai:ojs2.ojs.brazilianjournals.com.br:article/40640 |
| Acceso en línea: | https://ojs.brazilianjournals.com.br/ojs/index.php/BRJD/article/view/40640 |
| Access Level: | acceso abierto |
| Palabra clave: | Breast Neoplasm Immune System Tumor Microenvironment Prognosis Immunotherapy. |
| Sumario: | Globally, breast cancer is the most diagnosed neoplasm in women. In some countries, it’s consolidated as the type of neoplasm that causes the most deaths, being responsible for premature deaths. The molecular classification of cancer allows specific treatment for each patient; however, some types have resistance that results in an unfavorable prognosis. For this reason, researches are being developed in order to use the complexity of the immune system as a tool to combat the heterogeneity of breast cancer. Lately, studies have evaluated the leukocyte infiltrates present in the tumor microenvironment have become a promising field in therapeutic innovation, which is based on the cellular composition of the neoplastic environment of cancers with poor prognosis, whose immunotherapeutic action is specific to each molecular subtype. The expression of immune cells in the tumor microenvironment has potential for oncological parameters that can help in the treatment and also to define the prognosis. |
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