Cichlid fishes are promising underutilized models to investigate helminth-host-microbiome interactions

9 pages, 2 figures, supplementary material https://www.frontiersin.org/articles/10.3389/fimmu.2025.1527184/full#supplementary-material.-- Data availability statement: The original contributions presented in the study are included in the article/Supplementary Material. Further inquiries can be direct...

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Autores: Vanhove, Maarten P. M., Koblmüller, Stephan, Fernandes, Jorge M. O., Hahn, Christoph, Plusquin, Michelle, Kmentová, Nikol
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/386357
Acceso en línea:http://hdl.handle.net/10261/386357
Access Level:acceso abierto
Palabra clave:Cichlidae
Immunomodulation
Lake Tanganyika
Microbial diversity
Symbiome
Old friends hypothesis
Parasite
Worm
http://metadata.un.org/sdg/14
Conserve and sustainably use the oceans, seas and marine resources for sustainable development
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spelling Cichlid fishes are promising underutilized models to investigate helminth-host-microbiome interactionsVanhove, Maarten P. M.Koblmüller, StephanFernandes, Jorge M. O.Hahn, ChristophPlusquin, MichelleKmentová, NikolCichlidaeImmunomodulationLake TanganyikaMicrobial diversitySymbiomeOld friends hypothesisParasiteWormhttp://metadata.un.org/sdg/14Conserve and sustainably use the oceans, seas and marine resources for sustainable development9 pages, 2 figures, supplementary material https://www.frontiersin.org/articles/10.3389/fimmu.2025.1527184/full#supplementary-material.-- Data availability statement: The original contributions presented in the study are included in the article/Supplementary Material. Further inquiries can be directed to the corresponding authorsThe “Old Friends Hypothesis” suggests insufficient exposure to symbionts hinders immune development, contributing to increased immune-related diseases in the Global North. The microbiome is often the focus; helminths, potentially also offering health benefits, lack attention. Infection and effect of helminths are influenced and perhaps determined by micro-organisms. Mechanisms behind parasite-microbiome interactions are poorly understood, despite implications on host health. These interactions are typically studied for single helminth species in laboratory animal models, overlooking helminth diversity. Reviewing research on relationships between helminth and microbial diversity yielded 27 publications; most focused on human or other mammalian hosts, relying on natural exposure rather than experimental helminth inoculation. Only about half investigated host health outcomes. Remaining knowledge gaps warrant considering additional candidate model systems. Given the high helminthiasis burden and species diversity of helminths, we propose seeking models in the Global South, where a considerable proportion of research on diversity aspects of helminth-microbiome interactions took place. Low availability of genomic resources for helminths in the Global South, however, necessitates more integrative helminthological research efforts. Given substantial similarities in immune systems, several fishes are models for human health/disease. More effort could be done to establish this for cichlids, whose representatives in the African Great Lakes provide a well-delineated, closed natural system relevant to human health in view of fish-borne zoonoses and other water-borne parasites. A good baseline exists for these cichlids’ genomics, parasitology, and microbiology. We suggest exploring African Great Lake cichlids as model hosts for interactions between microbial diversity, helminth diversity, and host healthThis work was supported by the Special Research Fund of Hasselt University (BOF21INCENT09) and by the AfroWetMaP project of the Belgian Federal Science Policy Office (4255-FED-tWIN-G3 program, Prf-2022-049). This research was funded in part by the Austrian Science Fund (FWF) (grant DOI: 10.55776/P32691). JMOF acknowledges the institutional support of the grant ‘Severo Ochoa Centre of Excellence’ accreditation (CEX2019-000928-S) funded by AEI 10.13039/501100011033 (Spain)Peer reviewedFrontiers MediaHasselt UniversityBelgian Science Policy OfficeAustrian Science FundAgencia Estatal de Investigación (España)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202520252025info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/386357reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttps://doi.org/10.3389/fimmu.2025.1527184Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3863572026-05-22T06:33:51Z
dc.title.none.fl_str_mv Cichlid fishes are promising underutilized models to investigate helminth-host-microbiome interactions
title Cichlid fishes are promising underutilized models to investigate helminth-host-microbiome interactions
spellingShingle Cichlid fishes are promising underutilized models to investigate helminth-host-microbiome interactions
Vanhove, Maarten P. M.
Cichlidae
Immunomodulation
Lake Tanganyika
Microbial diversity
Symbiome
Old friends hypothesis
Parasite
Worm
http://metadata.un.org/sdg/14
Conserve and sustainably use the oceans, seas and marine resources for sustainable development
title_short Cichlid fishes are promising underutilized models to investigate helminth-host-microbiome interactions
title_full Cichlid fishes are promising underutilized models to investigate helminth-host-microbiome interactions
title_fullStr Cichlid fishes are promising underutilized models to investigate helminth-host-microbiome interactions
title_full_unstemmed Cichlid fishes are promising underutilized models to investigate helminth-host-microbiome interactions
title_sort Cichlid fishes are promising underutilized models to investigate helminth-host-microbiome interactions
dc.creator.none.fl_str_mv Vanhove, Maarten P. M.
Koblmüller, Stephan
Fernandes, Jorge M. O.
Hahn, Christoph
Plusquin, Michelle
Kmentová, Nikol
author Vanhove, Maarten P. M.
author_facet Vanhove, Maarten P. M.
Koblmüller, Stephan
Fernandes, Jorge M. O.
Hahn, Christoph
Plusquin, Michelle
Kmentová, Nikol
author_role author
author2 Koblmüller, Stephan
Fernandes, Jorge M. O.
Hahn, Christoph
Plusquin, Michelle
Kmentová, Nikol
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Hasselt University
Belgian Science Policy Office
Austrian Science Fund
Agencia Estatal de Investigación (España)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Cichlidae
Immunomodulation
Lake Tanganyika
Microbial diversity
Symbiome
Old friends hypothesis
Parasite
Worm
http://metadata.un.org/sdg/14
Conserve and sustainably use the oceans, seas and marine resources for sustainable development
topic Cichlidae
Immunomodulation
Lake Tanganyika
Microbial diversity
Symbiome
Old friends hypothesis
Parasite
Worm
http://metadata.un.org/sdg/14
Conserve and sustainably use the oceans, seas and marine resources for sustainable development
description 9 pages, 2 figures, supplementary material https://www.frontiersin.org/articles/10.3389/fimmu.2025.1527184/full#supplementary-material.-- Data availability statement: The original contributions presented in the study are included in the article/Supplementary Material. Further inquiries can be directed to the corresponding authors
publishDate 2025
dc.date.none.fl_str_mv 2025
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/386357
url http://hdl.handle.net/10261/386357
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://doi.org/10.3389/fimmu.2025.1527184
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.811543

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