Dopamine induces intracellular Ca2+ signals mediated by alpha(1B)-adrenoceptors in rat pineal cells
We have studied the functional interaction of dopamine with a -adrenoceptor subtypes by measuring intracellular Ca2q 1 levels in pineal cells, a cell type where adrenoceptors are well characterized. We show that dopamine induces transient intracellular Ca2q signals in only 70% of cells responding to...
| Autores: | , , , , |
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| Formato: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2001 |
| País: | España |
| Recursos: | Universidad de Sevilla (US) |
| Repositorio: | idUS. Depósito de Investigación de la Universidad de Sevilla |
| OAI Identifier: | oai:idus.us.es:11441/146635 |
| Acesso em linha: | https://hdl.handle.net/11441/146635 https://doi.org/10.1016/S0014-2999(01)01250-X |
| Access Level: | acceso abierto |
| Palavra-chave: | Dopamine α-Adrenoceptor Pineal cell Catecholamine |
| Resumo: | We have studied the functional interaction of dopamine with a -adrenoceptor subtypes by measuring intracellular Ca2q 1 levels in pineal cells, a cell type where adrenoceptors are well characterized. We show that dopamine induces transient intracellular Ca2q signals in only 70% of cells responding to phenylephrine. Dopamine-induced Ca2q signals desensitise faster than Ca2q transients elicited with phenylephrine and are selectively blocked by desipramine, imipramine, and a -adrenoceptor antagonists. These results suggest that 1B dopamine induced Ca2q signals are mainly due to the activation of one subtype of a-adrenoceptor, the a . |
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