Predictors of severe sepsis among patients hospitalized for community-acquired pneumonia

Background Severe sepsis, may be present on hospital arrival in approximately one-third of patients with community-acquired pneumonia (CAP). Objective To determine the host characteristics and micro-organisms associated with severe sepsis in patients hospitalized with CAP. Results We performed a pro...

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Autores: Montull, Beatriz, Menéndez, Rosario, Torres Martí, Antoni, Reyes, Soledad, Méndez, Raúl, Zalacaín, Rafael, Capelastegui, Alberto, Rajas, Olga, Borderías, Luis, Martín Villasclaras, Juan, Bello, Salvador, Alfageme, Inmaculada, Rodríguez de Castro, Felipe, Rello Condomines, Jordi, Molinos, Luis, Ruiz Manzano, Juan
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2016
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/105203
Acceso en línea:https://hdl.handle.net/2445/105203
Access Level:acceso abierto
Palabra clave:Septicèmia
Malalties pulmonars obstructives cròniques
Pneumònia
Antibiòtics
Septicemia
Chronic obstructive pulmonary diseases
Pneumonia
Antibiotics
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spelling Predictors of severe sepsis among patients hospitalized for community-acquired pneumoniaMontull, BeatrizMenéndez, RosarioTorres Martí, AntoniReyes, SoledadMéndez, RaúlZalacaín, RafaelCapelastegui, AlbertoRajas, OlgaBorderías, LuisMartín Villasclaras, JuanBello, SalvadorAlfageme, InmaculadaRodríguez de Castro, FelipeRello Condomines, JordiMolinos, LuisRuiz Manzano, JuanSepticèmiaMalalties pulmonars obstructives cròniquesPneumòniaAntibiòticsSepticemiaChronic obstructive pulmonary diseasesPneumoniaAntibioticsBackground Severe sepsis, may be present on hospital arrival in approximately one-third of patients with community-acquired pneumonia (CAP). Objective To determine the host characteristics and micro-organisms associated with severe sepsis in patients hospitalized with CAP. Results We performed a prospective multicenter cohort study in 13 Spanish hospital, on 4070 hospi- talized CAP patients, 1529 of whom (37.6%) presented with severe sepsis. Severe sepsis CAP was independently associated with older age ( > 65 years), alcohol abuse (OR, 1.31; 95% CI, 1.07 - 1.61), chronic obstructive pulmonary disease (COPD) (OR, 1.75; 95% CI, 1.50 - 2.04) and renal disease (OR, 1.57; 95% CI, 1.21 - 2.03), whereas prior antibiotic treat- ment was a protective factor (OR, 0.62; 95% CI, 0.52 - 0.73). Bacteremia (OR, 1.37; 95% CI, 1.05 - 1.79), S pneumoniae (OR, 1.59; 95% CI, 1.31 - 1.95) and mixed microbial etiology (OR, 1.65; 95% CI, 1.10 - 2.49) were associated with severe sepsis CAP. Conclusions CAP patients with COPD, renal disease and alcohol abuse, as well as those with CAP due to S pneumonia or mixed micro-organisms are more likely to present to the hospital with severe sepsis.Public Library of Science (PLoS)2017201720162017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion9 p.application/pdfhttps://hdl.handle.net/2445/105203Articles publicats en revistes (Medicina)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1371/journal.pone.0145929PLoS One, 2016, vol. 11, num. 1, p. e0145929https://doi.org/10.1371/journal.pone.0145929cc-by (c) Montull, Beatriz et al., 2016http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:recercat.cat:2445/1052032026-05-29T05:05:01Z
dc.title.none.fl_str_mv Predictors of severe sepsis among patients hospitalized for community-acquired pneumonia
title Predictors of severe sepsis among patients hospitalized for community-acquired pneumonia
spellingShingle Predictors of severe sepsis among patients hospitalized for community-acquired pneumonia
Montull, Beatriz
Septicèmia
Malalties pulmonars obstructives cròniques
Pneumònia
Antibiòtics
Septicemia
Chronic obstructive pulmonary diseases
Pneumonia
Antibiotics
title_short Predictors of severe sepsis among patients hospitalized for community-acquired pneumonia
title_full Predictors of severe sepsis among patients hospitalized for community-acquired pneumonia
title_fullStr Predictors of severe sepsis among patients hospitalized for community-acquired pneumonia
title_full_unstemmed Predictors of severe sepsis among patients hospitalized for community-acquired pneumonia
title_sort Predictors of severe sepsis among patients hospitalized for community-acquired pneumonia
dc.creator.none.fl_str_mv Montull, Beatriz
Menéndez, Rosario
Torres Martí, Antoni
Reyes, Soledad
Méndez, Raúl
Zalacaín, Rafael
Capelastegui, Alberto
Rajas, Olga
Borderías, Luis
Martín Villasclaras, Juan
Bello, Salvador
Alfageme, Inmaculada
Rodríguez de Castro, Felipe
Rello Condomines, Jordi
Molinos, Luis
Ruiz Manzano, Juan
author Montull, Beatriz
author_facet Montull, Beatriz
Menéndez, Rosario
Torres Martí, Antoni
Reyes, Soledad
Méndez, Raúl
Zalacaín, Rafael
Capelastegui, Alberto
Rajas, Olga
Borderías, Luis
Martín Villasclaras, Juan
Bello, Salvador
Alfageme, Inmaculada
Rodríguez de Castro, Felipe
Rello Condomines, Jordi
Molinos, Luis
Ruiz Manzano, Juan
author_role author
author2 Menéndez, Rosario
Torres Martí, Antoni
Reyes, Soledad
Méndez, Raúl
Zalacaín, Rafael
Capelastegui, Alberto
Rajas, Olga
Borderías, Luis
Martín Villasclaras, Juan
Bello, Salvador
Alfageme, Inmaculada
Rodríguez de Castro, Felipe
Rello Condomines, Jordi
Molinos, Luis
Ruiz Manzano, Juan
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Septicèmia
Malalties pulmonars obstructives cròniques
Pneumònia
Antibiòtics
Septicemia
Chronic obstructive pulmonary diseases
Pneumonia
Antibiotics
topic Septicèmia
Malalties pulmonars obstructives cròniques
Pneumònia
Antibiòtics
Septicemia
Chronic obstructive pulmonary diseases
Pneumonia
Antibiotics
description Background Severe sepsis, may be present on hospital arrival in approximately one-third of patients with community-acquired pneumonia (CAP). Objective To determine the host characteristics and micro-organisms associated with severe sepsis in patients hospitalized with CAP. Results We performed a prospective multicenter cohort study in 13 Spanish hospital, on 4070 hospi- talized CAP patients, 1529 of whom (37.6%) presented with severe sepsis. Severe sepsis CAP was independently associated with older age ( > 65 years), alcohol abuse (OR, 1.31; 95% CI, 1.07 - 1.61), chronic obstructive pulmonary disease (COPD) (OR, 1.75; 95% CI, 1.50 - 2.04) and renal disease (OR, 1.57; 95% CI, 1.21 - 2.03), whereas prior antibiotic treat- ment was a protective factor (OR, 0.62; 95% CI, 0.52 - 0.73). Bacteremia (OR, 1.37; 95% CI, 1.05 - 1.79), S pneumoniae (OR, 1.59; 95% CI, 1.31 - 1.95) and mixed microbial etiology (OR, 1.65; 95% CI, 1.10 - 2.49) were associated with severe sepsis CAP. Conclusions CAP patients with COPD, renal disease and alcohol abuse, as well as those with CAP due to S pneumonia or mixed micro-organisms are more likely to present to the hospital with severe sepsis.
publishDate 2016
dc.date.none.fl_str_mv 2016
2017
2017
2017
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/105203
url https://hdl.handle.net/2445/105203
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0145929
PLoS One, 2016, vol. 11, num. 1, p. e0145929
https://doi.org/10.1371/journal.pone.0145929
dc.rights.none.fl_str_mv cc-by (c) Montull, Beatriz et al., 2016
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Montull, Beatriz et al., 2016
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 9 p.
application/pdf
dc.publisher.none.fl_str_mv Public Library of Science (PLoS)
publisher.none.fl_str_mv Public Library of Science (PLoS)
dc.source.none.fl_str_mv Articles publicats en revistes (Medicina)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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