In vivo cholinergic basal forebrain degeneration and cognition in Parkinson's disease: Imaging results from the COPPADIS study
COPPADIS Study Group.
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2021 |
| País: | España |
| Institución: | Consejo Superior de Investigaciones Científicas (CSIC) |
| Repositorio: | DIGITAL.CSIC. Repositorio Institucional del CSIC |
| OAI Identifier: | oai:digital.csic.es:10261/266515 |
| Acceso en línea: | http://hdl.handle.net/10261/266515 |
| Access Level: | acceso abierto |
| Palabra clave: | Nucleus basalis Meynert Substantia innominata MRI DTI Diffusion Parkinson's disease |
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España |
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| dc.title.none.fl_str_mv |
In vivo cholinergic basal forebrain degeneration and cognition in Parkinson's disease: Imaging results from the COPPADIS study |
| title |
In vivo cholinergic basal forebrain degeneration and cognition in Parkinson's disease: Imaging results from the COPPADIS study |
| spellingShingle |
In vivo cholinergic basal forebrain degeneration and cognition in Parkinson's disease: Imaging results from the COPPADIS study Grothe, Michel J. Nucleus basalis Meynert Substantia innominata MRI DTI Diffusion Parkinson's disease |
| title_short |
In vivo cholinergic basal forebrain degeneration and cognition in Parkinson's disease: Imaging results from the COPPADIS study |
| title_full |
In vivo cholinergic basal forebrain degeneration and cognition in Parkinson's disease: Imaging results from the COPPADIS study |
| title_fullStr |
In vivo cholinergic basal forebrain degeneration and cognition in Parkinson's disease: Imaging results from the COPPADIS study |
| title_full_unstemmed |
In vivo cholinergic basal forebrain degeneration and cognition in Parkinson's disease: Imaging results from the COPPADIS study |
| title_sort |
In vivo cholinergic basal forebrain degeneration and cognition in Parkinson's disease: Imaging results from the COPPADIS study |
| dc.creator.none.fl_str_mv |
Grothe, Michel J. Labrador, Miguel Ángel Jesús Maestre, Silvia Macías García, Daniel Adarmes-Gómez, Astrid Carrillo, Fátima Iglesias Camacho, Elena Franco-Rosado, Pablo Roldán, Florinda Martín-Rodríguez, Juan Francisco Aguilar Barberá, Miquel Pastor, Pau Escalante, Sonia Solano Vila, Berta Cots Foraster, Ana Ruiz Martínez, Javier Carrillo Padilla, Francisco Pueyo Morlans, Mercedes González-Aramburu, Isabel Infante, Jon Hernández-Vara, Jorge Fábregues-Boixar, Oriol de Deus Fonticoba, T. de Pascual-Sedano, Berta Kulisevsky, Jaime Martínez-Martín, Pablo Santos-García, Diego Mir, Pablo |
| author |
Grothe, Michel J. |
| author_facet |
Grothe, Michel J. Labrador, Miguel Ángel Jesús Maestre, Silvia Macías García, Daniel Adarmes-Gómez, Astrid Carrillo, Fátima Iglesias Camacho, Elena Franco-Rosado, Pablo Roldán, Florinda Martín-Rodríguez, Juan Francisco Aguilar Barberá, Miquel Pastor, Pau Escalante, Sonia Solano Vila, Berta Cots Foraster, Ana Ruiz Martínez, Javier Carrillo Padilla, Francisco Pueyo Morlans, Mercedes González-Aramburu, Isabel Infante, Jon Hernández-Vara, Jorge Fábregues-Boixar, Oriol de Deus Fonticoba, T. de Pascual-Sedano, Berta Kulisevsky, Jaime Martínez-Martín, Pablo Santos-García, Diego Mir, Pablo |
| author_role |
author |
| author2 |
Labrador, Miguel Ángel Jesús Maestre, Silvia Macías García, Daniel Adarmes-Gómez, Astrid Carrillo, Fátima Iglesias Camacho, Elena Franco-Rosado, Pablo Roldán, Florinda Martín-Rodríguez, Juan Francisco Aguilar Barberá, Miquel Pastor, Pau Escalante, Sonia Solano Vila, Berta Cots Foraster, Ana Ruiz Martínez, Javier Carrillo Padilla, Francisco Pueyo Morlans, Mercedes González-Aramburu, Isabel Infante, Jon Hernández-Vara, Jorge Fábregues-Boixar, Oriol de Deus Fonticoba, T. de Pascual-Sedano, Berta Kulisevsky, Jaime Martínez-Martín, Pablo Santos-García, Diego Mir, Pablo |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Alzheimer Forschung Initiative Instituto de Salud Carlos III European Commission Junta de Andalucía Fundación Alicia Koplowitz Curemos el Párkinson Universidad de Sevilla Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72] |
| dc.subject.none.fl_str_mv |
Nucleus basalis Meynert Substantia innominata MRI DTI Diffusion Parkinson's disease |
| topic |
Nucleus basalis Meynert Substantia innominata MRI DTI Diffusion Parkinson's disease |
| description |
COPPADIS Study Group. |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2021 2022 2022 2022 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article http://purl.org/coar/resource_type/c_6501 Publisher's version info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/10261/266515 |
| url |
http://hdl.handle.net/10261/266515 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
http://dx.doi.org/10.1016/j.parkreldis.2021.05.027 Sí |
| dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.publisher.none.fl_str_mv |
Elsevier |
| publisher.none.fl_str_mv |
Elsevier |
| dc.source.none.fl_str_mv |
reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC instname:Consejo Superior de Investigaciones Científicas (CSIC) |
| instname_str |
Consejo Superior de Investigaciones Científicas (CSIC) |
| reponame_str |
DIGITAL.CSIC. Repositorio Institucional del CSIC |
| collection |
DIGITAL.CSIC. Repositorio Institucional del CSIC |
| repository.name.fl_str_mv |
|
| repository.mail.fl_str_mv |
|
| _version_ |
1869405448669495296 |
| spelling |
In vivo cholinergic basal forebrain degeneration and cognition in Parkinson's disease: Imaging results from the COPPADIS studyGrothe, Michel J.Labrador, Miguel ÁngelJesús Maestre, SilviaMacías García, DanielAdarmes-Gómez, AstridCarrillo, FátimaIglesias Camacho, ElenaFranco-Rosado, PabloRoldán, FlorindaMartín-Rodríguez, Juan FranciscoAguilar Barberá, MiquelPastor, PauEscalante, SoniaSolano Vila, BertaCots Foraster, AnaRuiz Martínez, JavierCarrillo Padilla, FranciscoPueyo Morlans, MercedesGonzález-Aramburu, IsabelInfante, JonHernández-Vara, JorgeFábregues-Boixar, Oriol deDeus Fonticoba, T. dePascual-Sedano, BertaKulisevsky, JaimeMartínez-Martín, PabloSantos-García, DiegoMir, PabloNucleus basalis MeynertSubstantia innominataMRIDTIDiffusionParkinson's diseaseCOPPADIS Study Group.[Introduction] We aimed to assess associations between multimodal neuroimaging measures of cholinergic basal forebrain (CBF) integrity and cognition in Parkinson's disease (PD) without dementia.[Methods] The study included a total of 180 non-demented PD patients and 45 healthy controls, who underwent structural MRI acquisitions and standardized neurocognitive assessment through the PD-Cognitive Rating Scale (PD-CRS) within the multicentric COPPADIS-2015 study. A subset of 73 patients also had Diffusion Tensor Imaging (DTI) acquisitions. Volumetric and microstructural (mean diffusivity, MD) indices of CBF degeneration were automatically extracted using a stereotactic CBF atlas. For comparison, we also assessed multimodal indices of hippocampal degeneration. Associations between imaging measures and cognitive performance were assessed using linear models.[Results] Compared to controls, CBF volume was not significantly reduced in PD patients as a group. However, across PD patients lower CBF volume was significantly associated with lower global cognition (PD-CRStotal: r = 0.37, p < 0.001), and this association remained significant after controlling for several potential confounding variables (p = 0.004). Analysis of individual item scores showed that this association spanned executive and memory domains. No analogue cognition associations were observed for CBF MD. In covariate-controlled models, hippocampal volume was not associated with cognition in PD, but there was a significant association for hippocampal MD (p = 0.02).[Conclusions] Early cognitive deficits in PD without dementia are more closely related to structural MRI measures of CBF degeneration than hippocampal degeneration. In our multicentric imaging acquisitions, DTI-based diffusion measures in the CBF were inferior to standard volumetric assessments for capturing cognition-relevant changes in non-demented PD.This work was supported by the Alzheimer Forschung Initiative e.V. (AFI International Training Grant to MJG), the Instituto de Salud Carlos III-Fondo Europeo de Desarrollo Regional (ISCIII-FEDER) [PI14/01823, PI16/01575, PI18/01898, PI19/01576, PI20/00613], the Consejería de Economía, Innovación, Ciencia y Empleo de la Junta de Andalucía [CVI-02526, CTS-7685], the Consejería de Salud y Bienestar Social de la Junta de Andalucía [PI-0471-2013, PE-0210-2018, PI-0459-2018, PE-0186-2019], the Fundación Alicia Koplowitz and the Fundación “Curemos el Parkinson” (https://www.curemoselparkinson.org). MJG is supported by the “Miguel Servet” program [CP19/00031], MALE by the University of Seville [USE-20046-J], JFM by the “Sara Borrell” program [CD13/00229] and VI-PPIT-US from the University of Seville [USE-18817-A], SJ by the “Acción B-Clínicos-Investigadores” program [B-0007-2019], and DMG by the “Río Hortega” program [CM18/00142].Peer reviewedElsevierAlzheimer Forschung InitiativeInstituto de Salud Carlos IIIEuropean CommissionJunta de AndalucíaFundación Alicia KoplowitzCuremos el PárkinsonUniversidad de SevillaConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2022202220212022info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/266515reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.1016/j.parkreldis.2021.05.027Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2665152026-05-22T06:33:51Z |
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15.81155 |