In vivo cholinergic basal forebrain degeneration and cognition in Parkinson's disease

Introduction: We aimed to assess associations between multimodal neuroimaging measures of cholinergic basal forebrain (CBF) integrity and cognition in Parkinson's disease (PD) without dementia. Methods: The study included a total of 180 non-demented PD patients and 45 healthy controls, who unde...

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Detalles Bibliográficos
Autores: Grothe, Michel|||0000-0003-2600-9022, Labrador-Espinosa, Miguel A.|||0000-0003-3576-1777, Jesús Maestre, Silvia|||0000-0002-1874-4628, Macías-García, Daniel|||0000-0002-4822-1529, Adarmes-Gómez, A.D.|||0000-0002-1337-9289, Carrillo, Fátima, Iglesias Camacho, Elena, Franco-Rosado, Pablo, Roldán Lora, Florinda, Martín-Rodríguez, Juan Francisco|||0000-0003-1392-8775, Aguilar Barberà, Miquel, Pastor, Pau|||0000-0002-7493-8777, Escalante, Sonia|||0000-0001-8931-1400, Soriano Vila, Berta, Cots-Foraster, Anna|||0000-0002-9169-7653, Ruiz Martínez, Javier|||0000-0001-7326-6270, Carrillo Padilla, Francisco, Pueyo Morlans, Mercedes, Gonzalez-Aramburu, Isabel|||0000-0002-3696-4093, Infante Ceberio, Jon, Hernández-Vara, Jorge|||0000-0002-9129-5224, Fàbregues-Boixar i Nebot, Oriol de|||0000-0002-3518-5338, de Deus Fonticoba, Teresa, Pascual Sedano, Berta María|||0000-0002-9298-8241, Kulisevsky, Jaime|||0000-0003-4870-1431, Martínez-Martín, Pablo, Santos García, Diego|||0000-0002-3126-5111, Mir, Pablo|||0000-0003-1656-302X
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:271915
Acceso en línea:https://ddd.uab.cat/record/271915
https://dx.doi.org/urn:doi:10.1016/j.parkreldis.2021.05.027
Access Level:acceso abierto
Palabra clave:Nucleus basalis Meynert
Substantia innominata
MRI
DTI
Diffusion
Parkinson's disease
Descripción
Sumario:Introduction: We aimed to assess associations between multimodal neuroimaging measures of cholinergic basal forebrain (CBF) integrity and cognition in Parkinson's disease (PD) without dementia. Methods: The study included a total of 180 non-demented PD patients and 45 healthy controls, who underwent structural MRI acquisitions and standardized neurocognitive assessment through the PD-Cognitive Rating Scale (PD-CRS) within the multicentric COPPADIS-2015 study. A subset of 73 patients also had Diffusion Tensor Imaging (DTI) acquisitions. Volumetric and microstructural (mean diffusivity, MD) indices of CBF degeneration were automatically extracted using a stereotactic CBF atlas. For comparison, we also assessed multimodal indices of hippocampal degeneration. Associations between imaging measures and cognitive performance were assessed using linear models. Results: Compared to controls, CBF volume was not significantly reduced in PD patients as a group. However, across PD patients lower CBF volume was significantly associated with lower global cognition (PD-CRS: r = 0.37, p < 0.001), and this association remained significant after controlling for several potential confounding variables (p = 0.004). Analysis of individual item scores showed that this association spanned executive and memory domains. No analogue cognition associations were observed for CBF MD. In covariate-controlled models, hippocampal volume was not associated with cognition in PD, but there was a significant association for hippocampal MD (p = 0.02). Conclusions: Early cognitive deficits in PD without dementia are more closely related to structural MRI measures of CBF degeneration than hippocampal degeneration. In our multicentric imaging acquisitions, DTI-based diffusion measures in the CBF were inferior to standard volumetric assessments for capturing cognition-relevant changes in non-demented PD.

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