Fibrin association at hybrid biointerfaces made of clot-binding peptides and polythiophene

The properties as biointerfaces of electroactive conducting polymer-peptide biocomposites formed by poly(3,4-ethylenedioxythiophene) (PEDOT) and CREKA or CR(NMe)EKA peptide sequences (where Glu has been replaced by N-methyl-Glu in the latter) have been compared. CREKA is a linear pentapeptide that r...

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Detalles Bibliográficos
Autores: Puiggalí Jou, Anna|||0000-0002-2234-9436, Valle Mendoza, Luis Javier del|||0000-0001-9916-1741, Armelín Diggroc, Elaine Aparecida|||0000-0002-0658-7696, Alemán Llansó, Carlos|||0000-0003-4462-6075
Tipo de recurso: artículo
Fecha de publicación:2016
País:España
Institución:Universitat Politècnica de Catalunya (UPC)
Repositorio:UPCommons. Portal del coneixement obert de la UPC
Idioma:inglés
OAI Identifier:oai:upcommons.upc.edu:2117/102130
Acceso en línea:https://hdl.handle.net/2117/102130
https://dx.doi.org/10.1002/mabi.201600128
Access Level:acceso abierto
Palabra clave:Peptides
Polymers
Biological interfaces
cell differentiation
electroactive polymers
fibrin adsorption
peptide-polymer composites
poly(3
4-ethylenedi-oxythiophene)
ray photoelectron-spectroscopy
conducting polymer
biomedical applications
derivatives
composites
pentapeptide
proteins
cancer
Pèptids
Polímers -- Biocompatibilitat
Àrees temàtiques de la UPC::Enginyeria química
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oai_identifier_str oai:upcommons.upc.edu:2117/102130
network_acronym_str ES
network_name_str España
repository_id_str
spelling Fibrin association at hybrid biointerfaces made of clot-binding peptides and polythiophenePuiggalí Jou, Anna|||0000-0002-2234-9436Valle Mendoza, Luis Javier del|||0000-0001-9916-1741Armelín Diggroc, Elaine Aparecida|||0000-0002-0658-7696Alemán Llansó, Carlos|||0000-0003-4462-6075PeptidesPolymersBiological interfacescell differentiationelectroactive polymersfibrin adsorptionpeptide-polymer compositespoly(34-ethylenedi-oxythiophene)ray photoelectron-spectroscopyconducting polymerbiomedical applicationsderivativescompositespentapeptideproteinscancerPèptidsPolímers -- BiocompatibilitatÀrees temàtiques de la UPC::Enginyeria químicaThe properties as biointerfaces of electroactive conducting polymer-peptide biocomposites formed by poly(3,4-ethylenedioxythiophene) (PEDOT) and CREKA or CR(NMe)EKA peptide sequences (where Glu has been replaced by N-methyl-Glu in the latter) have been compared. CREKA is a linear pentapeptide that recognizes clotted plasma proteins and selectively homes to tumors, while CR(NMe)EKA is an engineer to improve such properties by altering peptide-fibrin interactions. Differences between PEDOT-CREKA and PEDOT-CR(NMe)EKA reflect dissemblance in the organization of the peptides into the polymeric matrix. Both peptides affect fibrinogen thrombin-catalyzed polymerization causing the immediate formation of fibrin, whereas in the absence of thrombin this phenomenon is only observed for CR(NMe)EKA. Consistently, the fibrin-adsorption capacity is higher for PEDOT-CR(NMe)EKA than for PEDOT-CREKA, even though in both cases adsorbed fibrin exhibits round-like morphologies rather than the characteristic fibrous structure. PEDOT-peptide films coated with fibrin are selective in terms of cell adhesion, promoting the attachment of metastatic cells with respect to normal cells.Peer Reviewed20162016-10-0120172017-03-08journal articlehttp://purl.org/coar/resource_type/c_6501AMhttp://purl.org/coar/version/c_ab4af688f83e57aainfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/2117/102130https://dx.doi.org/10.1002/mabi.201600128reponame:UPCommons. Portal del coneixement obert de la UPCinstname:Universitat Politècnica de Catalunya (UPC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2http://creativecommons.org/licenses/by-nc-nd/3.0/es/info:eu-repo/semantics/openAccessoai:upcommons.upc.edu:2117/1021302026-05-27T15:37:01Z
dc.title.none.fl_str_mv Fibrin association at hybrid biointerfaces made of clot-binding peptides and polythiophene
title Fibrin association at hybrid biointerfaces made of clot-binding peptides and polythiophene
spellingShingle Fibrin association at hybrid biointerfaces made of clot-binding peptides and polythiophene
Puiggalí Jou, Anna|||0000-0002-2234-9436
Peptides
Polymers
Biological interfaces
cell differentiation
electroactive polymers
fibrin adsorption
peptide-polymer composites
poly(3
4-ethylenedi-oxythiophene)
ray photoelectron-spectroscopy
conducting polymer
biomedical applications
derivatives
composites
pentapeptide
proteins
cancer
Pèptids
Polímers -- Biocompatibilitat
Àrees temàtiques de la UPC::Enginyeria química
title_short Fibrin association at hybrid biointerfaces made of clot-binding peptides and polythiophene
title_full Fibrin association at hybrid biointerfaces made of clot-binding peptides and polythiophene
title_fullStr Fibrin association at hybrid biointerfaces made of clot-binding peptides and polythiophene
title_full_unstemmed Fibrin association at hybrid biointerfaces made of clot-binding peptides and polythiophene
title_sort Fibrin association at hybrid biointerfaces made of clot-binding peptides and polythiophene
dc.creator.none.fl_str_mv Puiggalí Jou, Anna|||0000-0002-2234-9436
Valle Mendoza, Luis Javier del|||0000-0001-9916-1741
Armelín Diggroc, Elaine Aparecida|||0000-0002-0658-7696
Alemán Llansó, Carlos|||0000-0003-4462-6075
author Puiggalí Jou, Anna|||0000-0002-2234-9436
author_facet Puiggalí Jou, Anna|||0000-0002-2234-9436
Valle Mendoza, Luis Javier del|||0000-0001-9916-1741
Armelín Diggroc, Elaine Aparecida|||0000-0002-0658-7696
Alemán Llansó, Carlos|||0000-0003-4462-6075
author_role author
author2 Valle Mendoza, Luis Javier del|||0000-0001-9916-1741
Armelín Diggroc, Elaine Aparecida|||0000-0002-0658-7696
Alemán Llansó, Carlos|||0000-0003-4462-6075
author2_role author
author
author
dc.subject.none.fl_str_mv Peptides
Polymers
Biological interfaces
cell differentiation
electroactive polymers
fibrin adsorption
peptide-polymer composites
poly(3
4-ethylenedi-oxythiophene)
ray photoelectron-spectroscopy
conducting polymer
biomedical applications
derivatives
composites
pentapeptide
proteins
cancer
Pèptids
Polímers -- Biocompatibilitat
Àrees temàtiques de la UPC::Enginyeria química
topic Peptides
Polymers
Biological interfaces
cell differentiation
electroactive polymers
fibrin adsorption
peptide-polymer composites
poly(3
4-ethylenedi-oxythiophene)
ray photoelectron-spectroscopy
conducting polymer
biomedical applications
derivatives
composites
pentapeptide
proteins
cancer
Pèptids
Polímers -- Biocompatibilitat
Àrees temàtiques de la UPC::Enginyeria química
description The properties as biointerfaces of electroactive conducting polymer-peptide biocomposites formed by poly(3,4-ethylenedioxythiophene) (PEDOT) and CREKA or CR(NMe)EKA peptide sequences (where Glu has been replaced by N-methyl-Glu in the latter) have been compared. CREKA is a linear pentapeptide that recognizes clotted plasma proteins and selectively homes to tumors, while CR(NMe)EKA is an engineer to improve such properties by altering peptide-fibrin interactions. Differences between PEDOT-CREKA and PEDOT-CR(NMe)EKA reflect dissemblance in the organization of the peptides into the polymeric matrix. Both peptides affect fibrinogen thrombin-catalyzed polymerization causing the immediate formation of fibrin, whereas in the absence of thrombin this phenomenon is only observed for CR(NMe)EKA. Consistently, the fibrin-adsorption capacity is higher for PEDOT-CR(NMe)EKA than for PEDOT-CREKA, even though in both cases adsorbed fibrin exhibits round-like morphologies rather than the characteristic fibrous structure. PEDOT-peptide films coated with fibrin are selective in terms of cell adhesion, promoting the attachment of metastatic cells with respect to normal cells.
publishDate 2016
dc.date.none.fl_str_mv 2016
2016-10-01
2017
2017-03-08
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
AM
http://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/2117/102130
https://dx.doi.org/10.1002/mabi.201600128
url https://hdl.handle.net/2117/102130
https://dx.doi.org/10.1002/mabi.201600128
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2

http://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2

http://creativecommons.org/licenses/by-nc-nd/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:UPCommons. Portal del coneixement obert de la UPC
instname:Universitat Politècnica de Catalunya (UPC)
instname_str Universitat Politècnica de Catalunya (UPC)
reponame_str UPCommons. Portal del coneixement obert de la UPC
collection UPCommons. Portal del coneixement obert de la UPC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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