VIM-2-producing Multidrug-Resistant Pseudomonas aeruginosa ST175 Clone, Spain
A total of 183 patients were colonized or infected with multidrug-resistant Pseudomonas aeruginosa isolates at a hospital in Spain during 2007-2010; prevalence increased over this period from 2.8% to 15.3%. To characterize these isolates, we performed molecular epidemiologic and drug resistance anal...
| Autores: | , , , , , , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2012 |
| País: | España |
| Institución: | Conselleria de Salut i Consum del Govern de les Illes Balears |
| Repositorio: | Docusalut |
| Idioma: | inglés |
| OAI Identifier: | oai:docusalut.com:20.500.13003/13065 |
| Acceso en línea: | https://hdl.handle.net/20.500.13003/13065 |
| Access Level: | acceso abierto |
| Palabra clave: | Cross Infection Pseudomonas Infections Molecular Epidemiology Sequence Analysis, DNA Prevalence Pseudomonas aeruginosa beta-Lactamases Female Multilocus Sequence Typing Male Middle Aged Humans DNA, Bacterial Genotype Aged Bacterial Typing Techniques Drug Resistance, Multiple, Bacterial Spain Anti-Bacterial Agents Microbial Sensitivity Tests beta-Lactamasas Tipificación de Secuencias Multilocus Pruebas de Sensibilidad Microbiana Humanos Persona de Mediana Edad Masculino ADN Bacteriano Anciano Infección Hospitalaria Genotipo Femenino Prevalencia Farmacorresistencia Bacteriana Múltiple Análisis de Secuencia de ADN Infecciones por Pseudomonas Antibacterianos Técnicas de Tipificación Bacteriana Epidemiología Molecular España |
| Sumario: | A total of 183 patients were colonized or infected with multidrug-resistant Pseudomonas aeruginosa isolates at a hospital in Spain during 2007-2010; prevalence increased over this period from 2.8% to 15.3%. To characterize these isolates, we performed molecular epidemiologic and drug resistance analysis. Genotyping showed that 104 (56.8%) isolates belonged to a single major clone (clone B), which was identified by multilocus sequence typing as sequence type (ST) 175. This clone was initially isolated from 5 patients in 2008, and then isolated from 23 patients in 2009 and 76 patients in 2010. PCR analysis of clone B isolates identified the b/a(VIM-2) gene in all but 1 isolate, which harbored b/a(IMP-22). ST175 isolates were susceptible to only amikacin (75%) and colistin (100%). Emergence of the ST175 clone represents a major health problem because it compromises therapy for treatment of P aeruginosa nosocomial infections. |
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