Somatostatin content and binding in small intestinal mucosa from fed, fasted and refed rabbits
The present study is an investigation of the effects of 12- to 96-hours' starvation and 96-hours' starvation plus 48-hours' refeeding on both somatostatin-like immunoreactivity (SLI) and cytosolic somatostatin binding sites in rabbit small intestinal mucosa. The SLI concentration incr...
| Autores: | , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 1990 |
| País: | España |
| Institución: | Universidad de Alcalá (UAH) |
| Repositorio: | e_Buah Biblioteca Digital Universidad de Alcalá |
| Idioma: | inglés |
| OAI Identifier: | oai:ebuah.uah.es:10017/3059 |
| Acceso en línea: | http://hdl.handle.net/10017/3059 https://dx.doi.org/10.1016/0024-3205(90)90439-X |
| Access Level: | acceso abierto |
| Palabra clave: | Somatostatin Intestinal mucosa Rabbits Bioquímica Ciencia Biochemistry Science |
| Sumario: | The present study is an investigation of the effects of 12- to 96-hours' starvation and 96-hours' starvation plus 48-hours' refeeding on both somatostatin-like immunoreactivity (SLI) and cytosolic somatostatin binding sites in rabbit small intestinal mucosa. The SLI concentration increased after 24 h in duodenal and jejunal mucosa, but not in ileal mucosa, and reached its highest value after 96 h of fasting. The number of specific high and low-affinity somatostatin binding sites, but not their affinity, decreased with the duration of fasting in the same gut segments, refeeding of fasted animals resulted in a return to normal control values for small intestine mucosal SLI and somatostatin binding. |
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