Relationship between adiponectin, TNFa, and SHBG in prepubertal children with obesity

BackgroundSex hormone-binding globulin (SHBG) levels are low in adult subjects with obesity when compared to normal-weight individuals. Obesity is associated with higher tumor necrosis factor alpha (TNF alpha) plasma levels and lower adiponectin levels. Moreover, we have recently elucidated the mole...

Descripción completa

Detalles Bibliográficos
Autores: Ramon-Krauel M, Leal-Witt MJ, Osorio-Conles Ó, Amat-Bou M, Lerin C, Selva DM
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Fundació Sant Joan de Déu
Repositorio:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
OAI Identifier:oai:fsjd.fundanetsuite.com:p19260
Acceso en línea:https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=19260
Access Level:acceso abierto
Palabra clave:Prepubertal children
Obesity
Sex hormone-binding globulin
Cytokines
id ES_2e834cbd0ead43aa6f86bcdda44ed519
oai_identifier_str oai:fsjd.fundanetsuite.com:p19260
network_acronym_str ES
network_name_str España
repository_id_str
spelling Relationship between adiponectin, TNFa, and SHBG in prepubertal children with obesityRamon-Krauel MLeal-Witt MJOsorio-Conles ÓAmat-Bou MLerin CSelva DMPrepubertal childrenObesitySex hormone-binding globulinCytokinesBackgroundSex hormone-binding globulin (SHBG) levels are low in adult subjects with obesity when compared to normal-weight individuals. Obesity is associated with higher tumor necrosis factor alpha (TNF alpha) plasma levels and lower adiponectin levels. Moreover, we have recently elucidated the molecular mechanisms by which TNF alpha and adiponectin regulate hepatic SHBG production.AimThe main objective of this study was to assess if the adult associations between TNF alpha, adiponectin, and SHBG are present in prepubertal children.MethodsWe determined several morphometric and biochemical parameters in normal-weight (n=15) and obese prepubertal (n=51) children, as well as quantified plasma SHBG, TNF alpha receptor 1 (TNF alpha-R1), and adiponectin levels.ResultsOur results showed that prepubertal children with obesity had decreased plasma SHBG levels compared to normal-weight controls (67 nmol/L vs 172 nmol/L). Importantly, SHBG plasma levels correlated significantly (P < 0.05) with TNF alpha (negatively, ssstd= - 0.31) and adiponectin (positively, ssstd= 0.58) suggesting an important role of these two cytokines in determining plasma SHBG levels in prepubertal children.ConclusionsOur results suggest that plasma adiponectin levels may play a more important role than TNF alpha in influencing plasma SHBG levels in our prepubertal population with obesity.SPRINGERNATURE2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=19260Molecular and Cellular PediatricsISSN: 21947791reponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déuinstname:Fundació Sant Joan de DéuInglésinfo:eu-repo/semantics/openAccessoai:fsjd.fundanetsuite.com:p192602026-05-27T12:37:41Z
dc.title.none.fl_str_mv Relationship between adiponectin, TNFa, and SHBG in prepubertal children with obesity
title Relationship between adiponectin, TNFa, and SHBG in prepubertal children with obesity
spellingShingle Relationship between adiponectin, TNFa, and SHBG in prepubertal children with obesity
Ramon-Krauel M
Prepubertal children
Obesity
Sex hormone-binding globulin
Cytokines
title_short Relationship between adiponectin, TNFa, and SHBG in prepubertal children with obesity
title_full Relationship between adiponectin, TNFa, and SHBG in prepubertal children with obesity
title_fullStr Relationship between adiponectin, TNFa, and SHBG in prepubertal children with obesity
title_full_unstemmed Relationship between adiponectin, TNFa, and SHBG in prepubertal children with obesity
title_sort Relationship between adiponectin, TNFa, and SHBG in prepubertal children with obesity
dc.creator.none.fl_str_mv Ramon-Krauel M
Leal-Witt MJ
Osorio-Conles Ó
Amat-Bou M
Lerin C
Selva DM
author Ramon-Krauel M
author_facet Ramon-Krauel M
Leal-Witt MJ
Osorio-Conles Ó
Amat-Bou M
Lerin C
Selva DM
author_role author
author2 Leal-Witt MJ
Osorio-Conles Ó
Amat-Bou M
Lerin C
Selva DM
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Prepubertal children
Obesity
Sex hormone-binding globulin
Cytokines
topic Prepubertal children
Obesity
Sex hormone-binding globulin
Cytokines
description BackgroundSex hormone-binding globulin (SHBG) levels are low in adult subjects with obesity when compared to normal-weight individuals. Obesity is associated with higher tumor necrosis factor alpha (TNF alpha) plasma levels and lower adiponectin levels. Moreover, we have recently elucidated the molecular mechanisms by which TNF alpha and adiponectin regulate hepatic SHBG production.AimThe main objective of this study was to assess if the adult associations between TNF alpha, adiponectin, and SHBG are present in prepubertal children.MethodsWe determined several morphometric and biochemical parameters in normal-weight (n=15) and obese prepubertal (n=51) children, as well as quantified plasma SHBG, TNF alpha receptor 1 (TNF alpha-R1), and adiponectin levels.ResultsOur results showed that prepubertal children with obesity had decreased plasma SHBG levels compared to normal-weight controls (67 nmol/L vs 172 nmol/L). Importantly, SHBG plasma levels correlated significantly (P < 0.05) with TNF alpha (negatively, ssstd= - 0.31) and adiponectin (positively, ssstd= 0.58) suggesting an important role of these two cytokines in determining plasma SHBG levels in prepubertal children.ConclusionsOur results suggest that plasma adiponectin levels may play a more important role than TNF alpha in influencing plasma SHBG levels in our prepubertal population with obesity.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=19260
url https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=19260
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv SPRINGERNATURE
publisher.none.fl_str_mv SPRINGERNATURE
dc.source.none.fl_str_mv Molecular and Cellular Pediatrics
ISSN: 21947791
reponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
instname:Fundació Sant Joan de Déu
instname_str Fundació Sant Joan de Déu
reponame_str r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
collection r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869405409926709248
score 15,811543

Similares en LA Referencia