Synthesis, in vitro profiling, and in vivo efficacy studies of a new family of multitarget antiAlzheimer compounds

Simultaneous modulation of several targets or athological events with a key pathogenic role is a promising strategy to tackle thus far difficult-to-cure or incurable multifactorial diseases, such as Alzheimer's disease (AD). In this scenario, multitarget compounds, i.e., single molecules that h...

Full description

Bibliographic Details
Authors: Pérez-Areales, Francisco Javier|||0000-0001-9525-9346, Garrido, María, Aso, Ester|||0000-0003-1836-1747, Bartolini, Manuela|||0000-0002-2890-3856, De Simone, Angela|||0000-0003-1915-458X, Espargaró Colomé, Alba, Ginex, Tiziana, Sabaté Lagunas, Raimon|||0000-0003-3894-2362, Pérez, Belén|||0000-0001-5801-1704, Andrisano, Vincenza|||0000-0003-4396-1904, Luque, Francisco Javier, Ferrer, Isidro|||0000-0001-9888-8754, Ciruela, Francisco|||0000-0003-0832-3739, Messeguer, Àngel, Muñoz-Torrero López-Ibarra, Diego|||0000-0002-8140-8555
Format: article
Publication Date:2019
Country:España
Institution:Universitat Autònoma de Barcelona
Repository:Dipòsit Digital de Documents de la UAB
Language:English
OAI Identifier:oai:ddd.uab.cat:217035
Online Access:https://ddd.uab.cat/record/217035
https://dx.doi.org/urn:doi:10.3390/proceedings2019022071
Access Level:Open access
Keyword:Multitarget compounds
Multitarget-directed ligands
Acetylcholinesterase inhibitors
Butyrylcholinesterase inhibitors
BACE-1 inhibitors
Anti-aggregating agents
Antioxidant
Properties
brain permeability
in vivo efficacy studies
id ES_2e47e525a94ee2fd75f7522e9bb9bfc5
oai_identifier_str oai:ddd.uab.cat:217035
network_acronym_str ES
network_name_str España
repository_id_str
spelling Synthesis, in vitro profiling, and in vivo efficacy studies of a new family of multitarget antiAlzheimer compoundsPérez-Areales, Francisco Javier|||0000-0001-9525-9346Garrido, MaríaAso, Ester|||0000-0003-1836-1747Bartolini, Manuela|||0000-0002-2890-3856De Simone, Angela|||0000-0003-1915-458XEspargaró Colomé, AlbaGinex, TizianaSabaté Lagunas, Raimon|||0000-0003-3894-2362Pérez, Belén|||0000-0001-5801-1704Andrisano, Vincenza|||0000-0003-4396-1904Luque, Francisco JavierFerrer, Isidro|||0000-0001-9888-8754Ciruela, Francisco|||0000-0003-0832-3739Messeguer, ÀngelMuñoz-Torrero López-Ibarra, Diego|||0000-0002-8140-8555Multitarget compoundsMultitarget-directed ligandsAcetylcholinesterase inhibitorsButyrylcholinesterase inhibitorsBACE-1 inhibitorsAnti-aggregating agentsAntioxidantPropertiesbrain permeabilityin vivo efficacy studiesSimultaneous modulation of several targets or athological events with a key pathogenic role is a promising strategy to tackle thus far difficult-to-cure or incurable multifactorial diseases, such as Alzheimer's disease (AD). In this scenario, multitarget compounds, i.e., single molecules that hit several targets, are superior to other multitarget strategies that are based on the use of more than one drug (drug cocktails, fixed-dose combinations), in terms of simpler drug development and better patient compliance, efficiency, and safety. 22019-01-0120192019-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/217035https://dx.doi.org/urn:doi:10.3390/proceedings2019022071reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2170352026-06-06T12:50:31Z
dc.title.none.fl_str_mv Synthesis, in vitro profiling, and in vivo efficacy studies of a new family of multitarget antiAlzheimer compounds
title Synthesis, in vitro profiling, and in vivo efficacy studies of a new family of multitarget antiAlzheimer compounds
spellingShingle Synthesis, in vitro profiling, and in vivo efficacy studies of a new family of multitarget antiAlzheimer compounds
Pérez-Areales, Francisco Javier|||0000-0001-9525-9346
Multitarget compounds
Multitarget-directed ligands
Acetylcholinesterase inhibitors
Butyrylcholinesterase inhibitors
BACE-1 inhibitors
Anti-aggregating agents
Antioxidant
Properties
brain permeability
in vivo efficacy studies
title_short Synthesis, in vitro profiling, and in vivo efficacy studies of a new family of multitarget antiAlzheimer compounds
title_full Synthesis, in vitro profiling, and in vivo efficacy studies of a new family of multitarget antiAlzheimer compounds
title_fullStr Synthesis, in vitro profiling, and in vivo efficacy studies of a new family of multitarget antiAlzheimer compounds
title_full_unstemmed Synthesis, in vitro profiling, and in vivo efficacy studies of a new family of multitarget antiAlzheimer compounds
title_sort Synthesis, in vitro profiling, and in vivo efficacy studies of a new family of multitarget antiAlzheimer compounds
dc.creator.none.fl_str_mv Pérez-Areales, Francisco Javier|||0000-0001-9525-9346
Garrido, María
Aso, Ester|||0000-0003-1836-1747
Bartolini, Manuela|||0000-0002-2890-3856
De Simone, Angela|||0000-0003-1915-458X
Espargaró Colomé, Alba
Ginex, Tiziana
Sabaté Lagunas, Raimon|||0000-0003-3894-2362
Pérez, Belén|||0000-0001-5801-1704
Andrisano, Vincenza|||0000-0003-4396-1904
Luque, Francisco Javier
Ferrer, Isidro|||0000-0001-9888-8754
Ciruela, Francisco|||0000-0003-0832-3739
Messeguer, Àngel
Muñoz-Torrero López-Ibarra, Diego|||0000-0002-8140-8555
author Pérez-Areales, Francisco Javier|||0000-0001-9525-9346
author_facet Pérez-Areales, Francisco Javier|||0000-0001-9525-9346
Garrido, María
Aso, Ester|||0000-0003-1836-1747
Bartolini, Manuela|||0000-0002-2890-3856
De Simone, Angela|||0000-0003-1915-458X
Espargaró Colomé, Alba
Ginex, Tiziana
Sabaté Lagunas, Raimon|||0000-0003-3894-2362
Pérez, Belén|||0000-0001-5801-1704
Andrisano, Vincenza|||0000-0003-4396-1904
Luque, Francisco Javier
Ferrer, Isidro|||0000-0001-9888-8754
Ciruela, Francisco|||0000-0003-0832-3739
Messeguer, Àngel
Muñoz-Torrero López-Ibarra, Diego|||0000-0002-8140-8555
author_role author
author2 Garrido, María
Aso, Ester|||0000-0003-1836-1747
Bartolini, Manuela|||0000-0002-2890-3856
De Simone, Angela|||0000-0003-1915-458X
Espargaró Colomé, Alba
Ginex, Tiziana
Sabaté Lagunas, Raimon|||0000-0003-3894-2362
Pérez, Belén|||0000-0001-5801-1704
Andrisano, Vincenza|||0000-0003-4396-1904
Luque, Francisco Javier
Ferrer, Isidro|||0000-0001-9888-8754
Ciruela, Francisco|||0000-0003-0832-3739
Messeguer, Àngel
Muñoz-Torrero López-Ibarra, Diego|||0000-0002-8140-8555
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Multitarget compounds
Multitarget-directed ligands
Acetylcholinesterase inhibitors
Butyrylcholinesterase inhibitors
BACE-1 inhibitors
Anti-aggregating agents
Antioxidant
Properties
brain permeability
in vivo efficacy studies
topic Multitarget compounds
Multitarget-directed ligands
Acetylcholinesterase inhibitors
Butyrylcholinesterase inhibitors
BACE-1 inhibitors
Anti-aggregating agents
Antioxidant
Properties
brain permeability
in vivo efficacy studies
description Simultaneous modulation of several targets or athological events with a key pathogenic role is a promising strategy to tackle thus far difficult-to-cure or incurable multifactorial diseases, such as Alzheimer's disease (AD). In this scenario, multitarget compounds, i.e., single molecules that hit several targets, are superior to other multitarget strategies that are based on the use of more than one drug (drug cocktails, fixed-dose combinations), in terms of simpler drug development and better patient compliance, efficiency, and safety.
publishDate 2019
dc.date.none.fl_str_mv 2
2019-01-01
2019
2019-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/217035
https://dx.doi.org/urn:doi:10.3390/proceedings2019022071
url https://ddd.uab.cat/record/217035
https://dx.doi.org/urn:doi:10.3390/proceedings2019022071
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869405393457774592
score 15,300719

Similar Items