Synthesis, in vitro profiling, and in vivo efficacy studies of a new family of multitarget anti-alzheimer compounds
Simultaneous modulation of several targets or pathological events with a key pathogenic role is a promising strategy to tackle thus far difficult-to-cure or incurable multifactorial diseases, such as Alzheimer’s disease (AD). In this scenario, multitarget compounds, i.e., single molecules that hit s...
| Autores: | , , , , , , , , , , , , , , |
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| Formato: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2019 |
| País: | España |
| Recursos: | Consejo Superior de Investigaciones Científicas (CSIC) |
| Repositorio: | DIGITAL.CSIC. Repositorio Institucional del CSIC |
| OAI Identifier: | oai:digital.csic.es:10261/190078 |
| Acesso em linha: | http://hdl.handle.net/10261/190078 |
| Access Level: | acceso abierto |
| Palavra-chave: | Multitarget compounds Multitarget-directed ligands Acetylcholinesterase inhibitors Butyrylcholinesterase inhibitors BACE-1 inhibitors Antioxidant properties Brain permeability In vivo efficacy studies Anti-aggregating agents |
| Resumo: | Simultaneous modulation of several targets or pathological events with a key pathogenic role is a promising strategy to tackle thus far difficult-to-cure or incurable multifactorial diseases, such as Alzheimer’s disease (AD). In this scenario, multitarget compounds, i.e., single molecules that hit several targets, are superior to other multitarget strategies that are based on the use of more than one drug (drug cocktails, fixed-dose combinations), in terms of simpler drug development and better patient compliance, efficiency, and safety. |
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