Alcohol intake and gastric cancer: Meta-analyses of published data versus individual participant data pooled analyses (StoP Project)

Background: Individual participant data pooled analyses allow access to non-published data and statistical reanalyses based on more homogeneous criteria than meta-analyses based on systematic reviews. We quantified the impact of publication-related biases and heterogeneity in data analysis and prese...

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Autores: Ferro A, Morais S, Rota M, Pelucchi C, Bertuccio P, Bonzi R, Galeone C, Zhang ZF, Matsuo K, Ito H, Hu J, Johnson KC, Yu GP, Palli D, Ferraroni M, Muscat J, Malekzadeh R, Ye W, Song H, Zaridze D, Maximovitch D, Fernández de Larrea N, Kogevinas M, Vioque J, Navarrete-Muñoz EM, Pakseresht M, Pourfarzi F, Wolk A, Orsini N, Bellavia A, Hakansson, Niclas, Mu L, Pastorino R, Kurtz RC, Derakhshan MH, Lagiou A, Lagiou P, Boffetta P, Boccia S, Negri E, La Vecchia C, Peleteiro B, Lunet N
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2018
País:España
Recursos:Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)
Repositorio:r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
OAI Identifier:oai:isabial.fundanetsuite.com:p2882
Acesso em linha:https://isabial.portalinvestigacion.com/publicaciones2882
Access Level:acceso abierto
Palavra-chave:Gastric cancer
Individual participant data
Meta-analysis
Pooled analysis
Alcohol
Publication bias
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spelling Alcohol intake and gastric cancer: Meta-analyses of published data versus individual participant data pooled analyses (StoP Project)Ferro AMorais SRota MPelucchi CBertuccio PBonzi RGaleone CZhang ZFMatsuo KIto HHu JJohnson KCYu GPPalli DFerraroni MMuscat JMalekzadeh RYe WSong HZaridze DMaximovitch DFernández de Larrea NKogevinas MVioque JNavarrete-Muñoz EMPakseresht MPourfarzi FWolk AOrsini NBellavia AHakansson, NiclasMu LPastorino RKurtz RCDerakhshan MHLagiou ALagiou PBoffetta PBoccia SNegri ELa Vecchia CPeleteiro BLunet NGastric cancerIndividual participant dataMeta-analysisPooled analysisAlcoholPublication biasBackground: Individual participant data pooled analyses allow access to non-published data and statistical reanalyses based on more homogeneous criteria than meta-analyses based on systematic reviews. We quantified the impact of publication-related biases and heterogeneity in data analysis and presentation in summary estimates of the association between alcohol drinking and gastric cancer. Methods: We compared estimates obtained from conventional meta-analyses, using only data available in published reports from studies that take part in the Stomach Cancer Pooling (StoP) Project, with individual participant data pooled analyses including the same studies. Results: A total of 22 studies from the StoP Project assessed the relation between alcohol intake and gastric cancer, 19 had specific data for levels of consumption and 18 according to cancer location; published reports addressing these associations were available from 18, 5 and 5 studies, respectively. The summary odds ratios [OR, (95%CI)] estimate obtained with published data for drinkers vs. non-drinkers was 10% higher than the one obtained with individual StoP data [18 vs. 22 studies: 1.21 (1.07-1.36) vs. 1.10 (0.99-1.23)] and more heterogeneous (1(2): 63.6% vs 54.4%). In general, published data yielded less precise summary estimates (standard errors up to 2.6 times higher). Funnel plot analysis suggested publication bias. Conclusion: Meta-analyses of the association between alcohol drinking and gastric cancer tended to overestimate the magnitude of the effects, possibly due to publication bias. Additionally, individual participant data pooled analyses yielded more precise estimates for different levels of exposure or cancer subtypes.ELSEVIER SCI LTD2018info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://isabial.portalinvestigacion.com/publicaciones2882Cancer EpidemiologyISSN: 18777821ISSNe: 1877783Xreponame:r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicanteinstname:Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)Inglésinfo:eu-repo/semantics/openAccessoai:isabial.fundanetsuite.com:p28822026-06-12T10:20:37Z
dc.title.none.fl_str_mv Alcohol intake and gastric cancer: Meta-analyses of published data versus individual participant data pooled analyses (StoP Project)
title Alcohol intake and gastric cancer: Meta-analyses of published data versus individual participant data pooled analyses (StoP Project)
spellingShingle Alcohol intake and gastric cancer: Meta-analyses of published data versus individual participant data pooled analyses (StoP Project)
Ferro A
Gastric cancer
Individual participant data
Meta-analysis
Pooled analysis
Alcohol
Publication bias
title_short Alcohol intake and gastric cancer: Meta-analyses of published data versus individual participant data pooled analyses (StoP Project)
title_full Alcohol intake and gastric cancer: Meta-analyses of published data versus individual participant data pooled analyses (StoP Project)
title_fullStr Alcohol intake and gastric cancer: Meta-analyses of published data versus individual participant data pooled analyses (StoP Project)
title_full_unstemmed Alcohol intake and gastric cancer: Meta-analyses of published data versus individual participant data pooled analyses (StoP Project)
title_sort Alcohol intake and gastric cancer: Meta-analyses of published data versus individual participant data pooled analyses (StoP Project)
dc.creator.none.fl_str_mv Ferro A
Morais S
Rota M
Pelucchi C
Bertuccio P
Bonzi R
Galeone C
Zhang ZF
Matsuo K
Ito H
Hu J
Johnson KC
Yu GP
Palli D
Ferraroni M
Muscat J
Malekzadeh R
Ye W
Song H
Zaridze D
Maximovitch D
Fernández de Larrea N
Kogevinas M
Vioque J
Navarrete-Muñoz EM
Pakseresht M
Pourfarzi F
Wolk A
Orsini N
Bellavia A
Hakansson, Niclas
Mu L
Pastorino R
Kurtz RC
Derakhshan MH
Lagiou A
Lagiou P
Boffetta P
Boccia S
Negri E
La Vecchia C
Peleteiro B
Lunet N
author Ferro A
author_facet Ferro A
Morais S
Rota M
Pelucchi C
Bertuccio P
Bonzi R
Galeone C
Zhang ZF
Matsuo K
Ito H
Hu J
Johnson KC
Yu GP
Palli D
Ferraroni M
Muscat J
Malekzadeh R
Ye W
Song H
Zaridze D
Maximovitch D
Fernández de Larrea N
Kogevinas M
Vioque J
Navarrete-Muñoz EM
Pakseresht M
Pourfarzi F
Wolk A
Orsini N
Bellavia A
Hakansson, Niclas
Mu L
Pastorino R
Kurtz RC
Derakhshan MH
Lagiou A
Lagiou P
Boffetta P
Boccia S
Negri E
La Vecchia C
Peleteiro B
Lunet N
author_role author
author2 Morais S
Rota M
Pelucchi C
Bertuccio P
Bonzi R
Galeone C
Zhang ZF
Matsuo K
Ito H
Hu J
Johnson KC
Yu GP
Palli D
Ferraroni M
Muscat J
Malekzadeh R
Ye W
Song H
Zaridze D
Maximovitch D
Fernández de Larrea N
Kogevinas M
Vioque J
Navarrete-Muñoz EM
Pakseresht M
Pourfarzi F
Wolk A
Orsini N
Bellavia A
Hakansson, Niclas
Mu L
Pastorino R
Kurtz RC
Derakhshan MH
Lagiou A
Lagiou P
Boffetta P
Boccia S
Negri E
La Vecchia C
Peleteiro B
Lunet N
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
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author
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author
author
dc.subject.none.fl_str_mv Gastric cancer
Individual participant data
Meta-analysis
Pooled analysis
Alcohol
Publication bias
topic Gastric cancer
Individual participant data
Meta-analysis
Pooled analysis
Alcohol
Publication bias
description Background: Individual participant data pooled analyses allow access to non-published data and statistical reanalyses based on more homogeneous criteria than meta-analyses based on systematic reviews. We quantified the impact of publication-related biases and heterogeneity in data analysis and presentation in summary estimates of the association between alcohol drinking and gastric cancer. Methods: We compared estimates obtained from conventional meta-analyses, using only data available in published reports from studies that take part in the Stomach Cancer Pooling (StoP) Project, with individual participant data pooled analyses including the same studies. Results: A total of 22 studies from the StoP Project assessed the relation between alcohol intake and gastric cancer, 19 had specific data for levels of consumption and 18 according to cancer location; published reports addressing these associations were available from 18, 5 and 5 studies, respectively. The summary odds ratios [OR, (95%CI)] estimate obtained with published data for drinkers vs. non-drinkers was 10% higher than the one obtained with individual StoP data [18 vs. 22 studies: 1.21 (1.07-1.36) vs. 1.10 (0.99-1.23)] and more heterogeneous (1(2): 63.6% vs 54.4%). In general, published data yielded less precise summary estimates (standard errors up to 2.6 times higher). Funnel plot analysis suggested publication bias. Conclusion: Meta-analyses of the association between alcohol drinking and gastric cancer tended to overestimate the magnitude of the effects, possibly due to publication bias. Additionally, individual participant data pooled analyses yielded more precise estimates for different levels of exposure or cancer subtypes.
publishDate 2018
dc.date.none.fl_str_mv 2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://isabial.portalinvestigacion.com/publicaciones2882
url https://isabial.portalinvestigacion.com/publicaciones2882
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv ELSEVIER SCI LTD
publisher.none.fl_str_mv ELSEVIER SCI LTD
dc.source.none.fl_str_mv Cancer Epidemiology
ISSN: 18777821
ISSNe: 1877783X
reponame:r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
instname:Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)
instname_str Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)
reponame_str r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
collection r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869405386763665408
score 15,811543

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