Tobacco smoking and gastric cancer: meta-analyses of published data versus pooled analyses of individual participant data (StoP Project)

Tobacco smoking is one of the main risk factors for gastric cancer, but the magnitude of the association estimated by conventional systematic reviews and meta-analyses might be inaccurate, due to heterogeneous reporting of data and publication bias. We aimed to quantify the combined impact of public...

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Detalles Bibliográficos
Autores: Ferro, Ana, Morais, Samantha, Rota, Matteo, Pelucchi, Claudio, Bertuccio, Paola, Bonzi, Rossella, Galeone, Carlotta, Zhang, Zuo-Feng, Matsuo, Keitaro, Ito, Hidemi, Hu, Jinfu, Johnson, Kenneth C., Yu, Guo-Pei, Palli, Domenico, Ferraroni, Monica, Muscat, Joshua, Malekzadeh, Reza, Ye, Weimin, Song, Huan, Zaridze, David, Maximovitch, Dmitry, Aragones, Nuria, Castano-Vinyals, Gemma, Vioque, Jesus, Navarrete-Munoz, Eva M., Pakseresht, Mohammadreza, Pourfarzi, Farhad, Wolk, Alicja, Orsini, Nicola, Bellavia, Andrea, Hakansson, Niclas, Mu, Lina, Pastorino, Roberta, Kurtz, Robert C., Derakhshan, Mohammad H., Lagiou, Areti, Lagiou, Pagona, Boffetta, Paolo, Boccia, Stefania, Negri, Eva, La Vecchia, Carlo, Peleteiro, Barbara, Lunet, Nuno
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2018
País:España
Institución:Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)
Repositorio:r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
OAI Identifier:oai:isabial.fundanetsuite.com:p2897
Acceso en línea:https://isabial.portalinvestigacion.com/publicaciones2897
Access Level:acceso abierto
Palabra clave:gastric cancer
individual participant data
meta-analysis
pooled analysis
tobacco
Descripción
Sumario:Tobacco smoking is one of the main risk factors for gastric cancer, but the magnitude of the association estimated by conventional systematic reviews and meta-analyses might be inaccurate, due to heterogeneous reporting of data and publication bias. We aimed to quantify the combined impact of publication-related biases, and heterogeneity in data analysis or presentation, in the summary estimates obtained from conventional meta-analyses. We compared results from individual participant data pooled-analyses, including the studies in the Stomach Cancer Pooling (StoP) Project, with conventional meta-analyses carried out using only data available in previously published reports from the same studies. From the 23 studies in the StoP Project, 20 had published reports with information on smoking and gastric cancer, but only six had specific data for gastric cardia cancer and seven had data on the daily number of cigarettes smoked. Compared to the results obtained with the StoP database, conventional meta-analyses overvalued the relation between ever smoking (summary odds ratios ranging from 7% higher for all studies to 22% higher for the risk of gastric cardia cancer) and yielded less precise summary estimates (SE 2.4 times higher). Additionally, funnel plot asymmetry and corresponding hypotheses tests were suggestive of publication bias. Conventional meta-analyses and individual participant data pooled-analyses reached similar conclusions on the direction of the association between smoking and gastric cancer. However, published data tended to overestimate the magnitude of the effects, possibly due to publication biases and limited the analyses by different levels of exposure or cancer subtypes. Copyright (c) 2018 Wolters Kluwer Health, Inc. All rights reserved.

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