Factors associated with atherosclerosis in radiographic and non-radiographic axial spondyloarthritis. A multicenter study on 838 patients
Objectives: To identify disease-related factors associated with subclinical atherosclerosis and cardiovascular (CV) events in a large series of patients with axial spondyloarthritis (axSpA) and to identify possible differences in the effect of the potential pro-atherogenic factors between ankylosing...
| Autores: | , , , , , , , , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2022 |
| País: | España |
| Institución: | Universidad de Cantabria (UC) |
| Repositorio: | UCrea Repositorio Abierto de la Universidad de Cantabria |
| Idioma: | inglés |
| OAI Identifier: | oai:repositorio.unican.es:10902/25090 |
| Acceso en línea: | http://hdl.handle.net/10902/25090 |
| Access Level: | acceso abierto |
| Palabra clave: | Ankylosing spondylitis Non-radiographic spondyloarthritis Atherosclerosis Cardiovascular Carotid ultrasound |
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Factors associated with atherosclerosis in radiographic and non-radiographic axial spondyloarthritis. A multicenter study on 838 patientsRueda Gotor, JavierFerraz Amaro, IvánGenre, FernandaGonzález Mazón, ÍñigoCorrales, AlfonsoCalvo Río, VanesaPortilla, VirginiaLlorca Díaz, Francisco Javier|||0000-0001-8569-861XExpósito, RosaHernández Hernández, VanesaQuevedo Abeledo, Juan CarlosRodríguez Lozano, CarlosLópez Medina, ClementinaLadehesa-Pineda, María LourdesCastañeda, SantosVicente, Esther F.Fernández-Carballido, CristinaMartínez-Vidal, M PazGonzález-Gay Mantecón, Miguel ÁngelAnkylosing spondylitisNon-radiographic spondyloarthritisAtherosclerosisCardiovascularCarotid ultrasoundObjectives: To identify disease-related factors associated with subclinical atherosclerosis and cardiovascular (CV) events in a large series of patients with axial spondyloarthritis (axSpA) and to identify possible differences in the effect of the potential pro-atherogenic factors between ankylosing spondylitis (AS) non-radiographic axSpA (nr-axSpA). Methods: This is a cross-sectional observational study of the AtheSpAin cohort, a Spanish multicenter cohort to study atherosclerosis in axSpA. Subclinical atherosclerosis determined by carotid ultrasound included assessment of carotid intima-media thickness (cIMT) and plaque detection. Results: 639 AS and 167 nr-axSpA patients were recruited. CV risk factors (CRF) and several disease-related factors showed a statistically significant association with subclinical atherosclerosis in the crude analysis. After adjustment for age, sex, and smoking (model 1), associations remained statistically significant for spinal mobility, inflammatory bowel disease, use of prednisone, and Disease-modifying antirheumatic drugs (DMARD) when assessing carotid plaques and for acute phase reactants (APR) at diagnosis, use of prednisone, DMARD, and TNF-inhibitors when measuring cIMT. In model 2, which also included classic CRF as confounding factors to identify axSpA features with a potential independent pro-atherogenic effect, the functional status was the only variable significantly associated with plaques and the use of prednisone and APR at diagnosis with cIMT. No association differences were found between both subtypes of patients. Besides, APR at diagnosis were also associated with subsequent development of CV events that had occurred in 33 patients. Conclusion: Apart from CRF, atherosclerotic disease in AxSpA is associated with disease-related factors such as inflammatory response and disease severity, with no differences between AS and nr-axSpA.ElsevierUniversidad de Cantabria20222022-01-01journal articlehttp://purl.org/coar/resource_type/c_6501NAhttp://purl.org/coar/version/c_be7fb7dd8ff6fe43info:eu-repo/semantics/articlehttp://hdl.handle.net/10902/25090Semin Arthritis Rheum . 2022 May 28;55:152037reponame:UCrea Repositorio Abierto de la Universidad de Cantabriainstname:Universidad de Cantabria (UC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:repositorio.unican.es:10902/250902026-06-02T12:39:31Z |
| dc.title.none.fl_str_mv |
Factors associated with atherosclerosis in radiographic and non-radiographic axial spondyloarthritis. A multicenter study on 838 patients |
| title |
Factors associated with atherosclerosis in radiographic and non-radiographic axial spondyloarthritis. A multicenter study on 838 patients |
| spellingShingle |
Factors associated with atherosclerosis in radiographic and non-radiographic axial spondyloarthritis. A multicenter study on 838 patients Rueda Gotor, Javier Ankylosing spondylitis Non-radiographic spondyloarthritis Atherosclerosis Cardiovascular Carotid ultrasound |
| title_short |
Factors associated with atherosclerosis in radiographic and non-radiographic axial spondyloarthritis. A multicenter study on 838 patients |
| title_full |
Factors associated with atherosclerosis in radiographic and non-radiographic axial spondyloarthritis. A multicenter study on 838 patients |
| title_fullStr |
Factors associated with atherosclerosis in radiographic and non-radiographic axial spondyloarthritis. A multicenter study on 838 patients |
| title_full_unstemmed |
Factors associated with atherosclerosis in radiographic and non-radiographic axial spondyloarthritis. A multicenter study on 838 patients |
| title_sort |
Factors associated with atherosclerosis in radiographic and non-radiographic axial spondyloarthritis. A multicenter study on 838 patients |
| dc.creator.none.fl_str_mv |
Rueda Gotor, Javier Ferraz Amaro, Iván Genre, Fernanda González Mazón, Íñigo Corrales, Alfonso Calvo Río, Vanesa Portilla, Virginia Llorca Díaz, Francisco Javier|||0000-0001-8569-861X Expósito, Rosa Hernández Hernández, Vanesa Quevedo Abeledo, Juan Carlos Rodríguez Lozano, Carlos López Medina, Clementina Ladehesa-Pineda, María Lourdes Castañeda, Santos Vicente, Esther F. Fernández-Carballido, Cristina Martínez-Vidal, M Paz González-Gay Mantecón, Miguel Ángel |
| author |
Rueda Gotor, Javier |
| author_facet |
Rueda Gotor, Javier Ferraz Amaro, Iván Genre, Fernanda González Mazón, Íñigo Corrales, Alfonso Calvo Río, Vanesa Portilla, Virginia Llorca Díaz, Francisco Javier|||0000-0001-8569-861X Expósito, Rosa Hernández Hernández, Vanesa Quevedo Abeledo, Juan Carlos Rodríguez Lozano, Carlos López Medina, Clementina Ladehesa-Pineda, María Lourdes Castañeda, Santos Vicente, Esther F. Fernández-Carballido, Cristina Martínez-Vidal, M Paz González-Gay Mantecón, Miguel Ángel |
| author_role |
author |
| author2 |
Ferraz Amaro, Iván Genre, Fernanda González Mazón, Íñigo Corrales, Alfonso Calvo Río, Vanesa Portilla, Virginia Llorca Díaz, Francisco Javier|||0000-0001-8569-861X Expósito, Rosa Hernández Hernández, Vanesa Quevedo Abeledo, Juan Carlos Rodríguez Lozano, Carlos López Medina, Clementina Ladehesa-Pineda, María Lourdes Castañeda, Santos Vicente, Esther F. Fernández-Carballido, Cristina Martínez-Vidal, M Paz González-Gay Mantecón, Miguel Ángel |
| author2_role |
author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Universidad de Cantabria |
| dc.subject.none.fl_str_mv |
Ankylosing spondylitis Non-radiographic spondyloarthritis Atherosclerosis Cardiovascular Carotid ultrasound |
| topic |
Ankylosing spondylitis Non-radiographic spondyloarthritis Atherosclerosis Cardiovascular Carotid ultrasound |
| description |
Objectives: To identify disease-related factors associated with subclinical atherosclerosis and cardiovascular (CV) events in a large series of patients with axial spondyloarthritis (axSpA) and to identify possible differences in the effect of the potential pro-atherogenic factors between ankylosing spondylitis (AS) non-radiographic axSpA (nr-axSpA). Methods: This is a cross-sectional observational study of the AtheSpAin cohort, a Spanish multicenter cohort to study atherosclerosis in axSpA. Subclinical atherosclerosis determined by carotid ultrasound included assessment of carotid intima-media thickness (cIMT) and plaque detection. Results: 639 AS and 167 nr-axSpA patients were recruited. CV risk factors (CRF) and several disease-related factors showed a statistically significant association with subclinical atherosclerosis in the crude analysis. After adjustment for age, sex, and smoking (model 1), associations remained statistically significant for spinal mobility, inflammatory bowel disease, use of prednisone, and Disease-modifying antirheumatic drugs (DMARD) when assessing carotid plaques and for acute phase reactants (APR) at diagnosis, use of prednisone, DMARD, and TNF-inhibitors when measuring cIMT. In model 2, which also included classic CRF as confounding factors to identify axSpA features with a potential independent pro-atherogenic effect, the functional status was the only variable significantly associated with plaques and the use of prednisone and APR at diagnosis with cIMT. No association differences were found between both subtypes of patients. Besides, APR at diagnosis were also associated with subsequent development of CV events that had occurred in 33 patients. Conclusion: Apart from CRF, atherosclerotic disease in AxSpA is associated with disease-related factors such as inflammatory response and disease severity, with no differences between AS and nr-axSpA. |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022 2022-01-01 |
| dc.type.none.fl_str_mv |
journal article http://purl.org/coar/resource_type/c_6501 NA http://purl.org/coar/version/c_be7fb7dd8ff6fe43 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/10902/25090 |
| url |
http://hdl.handle.net/10902/25090 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| dc.rights.openaire.fl_str_mv |
info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ |
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openAccess |
| dc.publisher.none.fl_str_mv |
Elsevier |
| publisher.none.fl_str_mv |
Elsevier |
| dc.source.none.fl_str_mv |
Semin Arthritis Rheum . 2022 May 28;55:152037 reponame:UCrea Repositorio Abierto de la Universidad de Cantabria instname:Universidad de Cantabria (UC) |
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Universidad de Cantabria (UC) |
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UCrea Repositorio Abierto de la Universidad de Cantabria |
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UCrea Repositorio Abierto de la Universidad de Cantabria |
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