Factors associated with atherosclerosis in radiographic and non-radiographic axial spondyloarthritis. A multicenter study on 838 patients

Objectives: To identify disease-related factors associated with subclinical atherosclerosis and cardiovascular (CV) events in a large series of patients with axial spondyloarthritis (axSpA) and to identify possible differences in the effect of the potential pro-atherogenic factors between ankylosing...

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Detalles Bibliográficos
Autores: Rueda-Gotor, J, Ferraz-Amaro, I, Genre, F, Gonzalez-Mazon, I, Corrales, A, Calvo-Rio, V, Portilla, V, Llorca, J, Exposito, R, Hernandez-Hernandez, V, Quevedo-Abeledo, JC, Rodriguez-Lozano, C, Lopez-Medina, C, Ladehesa-Pineda, ML, Castaneda, S, Vicente, EF, Fernandez-Carballido, C, Martinez-Vidal, MP, Castro-Corredor, D, Anino-Fernandez, J, Peiteado, D, Plasencia-Rodriguez, C, Garcia-Vivar, ML, Galindez-Agirregoikoa, E, Montes-Perez, E, Fernandez-Diaz, C, Blanco, R, Gonzalez-Gay, MA
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
Repositorio:r-FISABIO. Repositorio Institucional de Producción Científica
OAI Identifier:oai:fisabio.fundanetsuite.com:p14636
Acceso en línea:https://fisabio.portalinvestigacion.com/publicaciones/14636
Access Level:acceso abierto
Palabra clave:Ankylosing spondylitis
Non-radiographic spondyloarthritis
Atherosclerosis
Cardiovascular
Carotid ultrasound
Descripción
Sumario:Objectives: To identify disease-related factors associated with subclinical atherosclerosis and cardiovascular (CV) events in a large series of patients with axial spondyloarthritis (axSpA) and to identify possible differences in the effect of the potential pro-atherogenic factors between ankylosing spondylitis (AS) non-radiographic axSpA (nraxSpA). Methods: This is a cross-sectional observational study of the AtheSpAin cohort, a Spanish multicenter cohort to study atherosclerosis in axSpA. Subclinical atherosclerosis determined by carotid ultrasound included assessment of carotid intima-media thickness (cIMT) and plaque detection. Results: 639 AS and 167 nr-axSpA patients were recruited. CV risk factors (CRF) and several disease-related factors showed a statistically significant association with subclinical atherosclerosis in the crude analysis. After adjustment for age, sex, and smoking (model 1), associations remained statistically significant for spinal mobility, inflammatory bowel disease, use of prednisone, and Disease-modifying antirheumatic drugs (DMARD) when assessing carotid plaques and for acute phase reactants (APR) at diagnosis, use of prednisone, DMARD, and TNF-inhibitors when measuring cIMT. In model 2, which also included classic CRF as confounding factors to identify axSpA features with a potential independent pro-athemgenic effect, the functional status was the only variable significantly associated with plaques and the use of prednisone and APR at diagnosis with cIMT. No association differences were found between both subtypes of patients. Besides, APR at diagnosis were also associated with subsequent development of CV events that had occurred in 33 patients. Conclusion: Apart from CRF, atherosclerotic disease in AxSpA is associated with disease-related factors such as inflammatory response and disease severity, with no differences between AS and nr-axSpA.

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