Increased FOXJ1 protein expression is associated with improved overall survival in high-grade serous ovarian carcinoma: an Ovarian Tumor Tissue Analysis Consortium Study.

Weir, Ashley; Kang, Eun-Young; Meagher, Nicola S; Nelson, Gregg S; Ghatage, Prafull; Lee, Cheng-Han; Riggan, Marjorie J; Gentry-Maharaj, Aleksandra; Ryan, Andy; Singh, Naveena; Widschwendter, Martin; Alsop, Jennifer; Anglesio, Michael S; Beckmann, Matthias W; Berger, Jessica; Bisinotto, Christiani; Boros, Jessica; Brand, Alison H; Brenton, James D; Brooks-Wilson, Angela; Carney, Michael E; Cunningham, Julie M; Cushing-Haugen, Kara L; Cybulski, Cezary; Elishaev, Esther; Erber, Ramona; Fereday, Sian; Fischer, Anna; Paz Ares, Luis Gonzaga; Gayarre, Javier; Gilks, Blake C; Grube, Marcel; Harnett, Paul R; Harris, Holly R; Hartmann, Arndt; Hein, Alexander; Hendley, Joy; Hernandez, Brenda Y; Heublein, Sabine; Huang, Yajue; Huzarski, Tomasz; Jakubowska, Anna; Jimenez-Linan, Mercedes; Kennedy, Catherine J; Kommoss, Felix K F; Koziak, Jennifer M; Kraemer, Bernhard; Le, Nhu D; Lesnock, Jaime; Lester, Jenny; Lubiński, Jan; Menkiszak, Janusz; Ney, Britta; Olawaiye, Alexander; Orsulic, Sandra; Osorio, Ana; Robles-Díaz, Luis; Ruebner, Matthias; Shah, Mitul; Sharma, Raghwa; Shvetsov, Yurii B; Steed, Helen; Talhouk, Aline; Taylor, Sarah E; Traficante, Nadia; Vierkant, Robert A; Wang, Chen; Wilkens, Lynne R; Winham, Stacey J; Benitez, Javier; Berchuck, Andrew; Bowtell, David D; Candido Dos Reis, Francisco J; Cook, Linda S; DeFazio, Anna; Doherty, Jennifer A; Fasching, Peter A; García, María J; Goode, Ellen L; Goodman, Marc T; Gronwald, Jacek; Huntsman, David G; Karlan, Beth Y; Kommoss, Stefan; Modugno, Francesmary; Schildkraut, Joellen M; Sinn, Hans-Peter; Staebler, Annette; Kelemen, Linda E; Ford, Caroline E; Menon, Usha; Pharoah, Paul D P; Köbel, Martin; Ramus, Susan J

Increased FOXJ1 protein expression is associated with improved overall survival in high-grade serous ovarian carcinoma: an Ovarian Tumor Tissue Analysis Consortium Study.

BACKGROUND Recently, we showed a >60% difference in 5-year survival for patients with tubo-ovarian high-grade serous carcinoma (HGSC) when stratified by a 101-gene mRNA expression prognostic signature. Given the varied patient outcomes, this study aimed to translate prognostic mRNA markers into p...

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Autores:	Weir, Ashley, Kang, Eun-Young, Meagher, Nicola S, Nelson, Gregg S, Ghatage, Prafull, Lee, Cheng-Han, Riggan, Marjorie J, Gentry-Maharaj, Aleksandra, Ryan, Andy, Singh, Naveena, Widschwendter, Martin, Alsop, Jennifer, Anglesio, Michael S, Beckmann, Matthias W, Berger, Jessica, Bisinotto, Christiani, Boros, Jessica, Brand, Alison H, Brenton, James D, Brooks-Wilson, Angela, Carney, Michael E, Cunningham, Julie M, Cushing-Haugen, Kara L, Cybulski, Cezary, Elishaev, Esther, Erber, Ramona, Fereday, Sian, Fischer, Anna, Paz Ares, Luis Gonzaga, Gayarre, Javier, Gilks, Blake C, Grube, Marcel, Harnett, Paul R, Harris, Holly R, Hartmann, Arndt, Hein, Alexander, Hendley, Joy, Hernandez, Brenda Y, Heublein, Sabine, Huang, Yajue, Huzarski, Tomasz, Jakubowska, Anna, Jimenez-Linan, Mercedes, Kennedy, Catherine J, Kommoss, Felix K F, Koziak, Jennifer M, Kraemer, Bernhard, Le, Nhu D, Lesnock, Jaime, Lester, Jenny, Lubiński, Jan, Menkiszak, Janusz, Ney, Britta, Olawaiye, Alexander, Orsulic, Sandra, Osorio, Ana, Robles-Díaz, Luis, Ruebner, Matthias, Shah, Mitul, Sharma, Raghwa, Shvetsov, Yurii B, Steed, Helen, Talhouk, Aline, Taylor, Sarah E, Traficante, Nadia, Vierkant, Robert A, Wang, Chen, Wilkens, Lynne R, Winham, Stacey J, Benitez, Javier, Berchuck, Andrew, Bowtell, David D, Candido Dos Reis, Francisco J, Cook, Linda S, DeFazio, Anna, Doherty, Jennifer A, Fasching, Peter A, García, María J, Goode, Ellen L, Goodman, Marc T, Gronwald, Jacek, Huntsman, David G, Karlan, Beth Y, Kommoss, Stefan, Modugno, Francesmary, Schildkraut, Joellen M, Sinn, Hans-Peter, Staebler, Annette, Kelemen, Linda E, Ford, Caroline E, Menon, Usha, Pharoah, Paul D P, Köbel, Martin, Ramus, Susan J
Tipo de recurso:	artículo
Fecha de publicación:	2023
País:	España
Institución:	Instituto de Salud Carlos III (ISCIII)
Repositorio:	Repisalud
Idioma:	inglés
OAI Identifier:	oai:repisalud.isciii.es:20.500.12105/18900
Acceso en línea:	http://hdl.handle.net/20.500.12105/18900
Access Level:	acceso abierto
Palabra clave:	Ovarian Neoplasms Cystadenocarcinoma, Serous Humans Female Prognosis Survival Analysis RNA, Messenger Biomarkers, Tumor Forkhead Transcription Factors

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network_acronym_str	ES
network_name_str	España
repository_id_str
dc.title.none.fl_str_mv	Increased FOXJ1 protein expression is associated with improved overall survival in high-grade serous ovarian carcinoma: an Ovarian Tumor Tissue Analysis Consortium Study.
title	Increased FOXJ1 protein expression is associated with improved overall survival in high-grade serous ovarian carcinoma: an Ovarian Tumor Tissue Analysis Consortium Study.
spellingShingle	Increased FOXJ1 protein expression is associated with improved overall survival in high-grade serous ovarian carcinoma: an Ovarian Tumor Tissue Analysis Consortium Study. Weir, Ashley Ovarian Neoplasms Cystadenocarcinoma, Serous Humans Female Prognosis Survival Analysis RNA, Messenger Biomarkers, Tumor Forkhead Transcription Factors
title_short	Increased FOXJ1 protein expression is associated with improved overall survival in high-grade serous ovarian carcinoma: an Ovarian Tumor Tissue Analysis Consortium Study.
title_full	Increased FOXJ1 protein expression is associated with improved overall survival in high-grade serous ovarian carcinoma: an Ovarian Tumor Tissue Analysis Consortium Study.
title_fullStr	Increased FOXJ1 protein expression is associated with improved overall survival in high-grade serous ovarian carcinoma: an Ovarian Tumor Tissue Analysis Consortium Study.
title_full_unstemmed	Increased FOXJ1 protein expression is associated with improved overall survival in high-grade serous ovarian carcinoma: an Ovarian Tumor Tissue Analysis Consortium Study.
title_sort	Increased FOXJ1 protein expression is associated with improved overall survival in high-grade serous ovarian carcinoma: an Ovarian Tumor Tissue Analysis Consortium Study.
dc.creator.none.fl_str_mv	Weir, Ashley Kang, Eun-Young Meagher, Nicola S Nelson, Gregg S Ghatage, Prafull Lee, Cheng-Han Riggan, Marjorie J Gentry-Maharaj, Aleksandra Ryan, Andy Singh, Naveena Widschwendter, Martin Alsop, Jennifer Anglesio, Michael S Beckmann, Matthias W Berger, Jessica Bisinotto, Christiani Boros, Jessica Brand, Alison H Brenton, James D Brooks-Wilson, Angela Carney, Michael E Cunningham, Julie M Cushing-Haugen, Kara L Cybulski, Cezary Elishaev, Esther Erber, Ramona Fereday, Sian Fischer, Anna Paz Ares, Luis Gonzaga Gayarre, Javier Gilks, Blake C Grube, Marcel Harnett, Paul R Harris, Holly R Hartmann, Arndt Hein, Alexander Hendley, Joy Hernandez, Brenda Y Heublein, Sabine Huang, Yajue Huzarski, Tomasz Jakubowska, Anna Jimenez-Linan, Mercedes Kennedy, Catherine J Kommoss, Felix K F Koziak, Jennifer M Kraemer, Bernhard Le, Nhu D Lesnock, Jaime Lester, Jenny Lubiński, Jan Menkiszak, Janusz Ney, Britta Olawaiye, Alexander Orsulic, Sandra Osorio, Ana Robles-Díaz, Luis Ruebner, Matthias Shah, Mitul Sharma, Raghwa Shvetsov, Yurii B Steed, Helen Talhouk, Aline Taylor, Sarah E Traficante, Nadia Vierkant, Robert A Wang, Chen Wilkens, Lynne R Winham, Stacey J Benitez, Javier Berchuck, Andrew Bowtell, David D Candido Dos Reis, Francisco J Cook, Linda S DeFazio, Anna Doherty, Jennifer A Fasching, Peter A García, María J Goode, Ellen L Goodman, Marc T Gronwald, Jacek Huntsman, David G Karlan, Beth Y Kommoss, Stefan Modugno, Francesmary Schildkraut, Joellen M Sinn, Hans-Peter Staebler, Annette Kelemen, Linda E Ford, Caroline E Menon, Usha Pharoah, Paul D P Köbel, Martin Ramus, Susan J
author	Weir, Ashley
author_facet	Weir, Ashley Kang, Eun-Young Meagher, Nicola S Nelson, Gregg S Ghatage, Prafull Lee, Cheng-Han Riggan, Marjorie J Gentry-Maharaj, Aleksandra Ryan, Andy Singh, Naveena Widschwendter, Martin Alsop, Jennifer Anglesio, Michael S Beckmann, Matthias W Berger, Jessica Bisinotto, Christiani Boros, Jessica Brand, Alison H Brenton, James D Brooks-Wilson, Angela Carney, Michael E Cunningham, Julie M Cushing-Haugen, Kara L Cybulski, Cezary Elishaev, Esther Erber, Ramona Fereday, Sian Fischer, Anna Paz Ares, Luis Gonzaga Gayarre, Javier Gilks, Blake C Grube, Marcel Harnett, Paul R Harris, Holly R Hartmann, Arndt Hein, Alexander Hendley, Joy Hernandez, Brenda Y Heublein, Sabine Huang, Yajue Huzarski, Tomasz Jakubowska, Anna Jimenez-Linan, Mercedes Kennedy, Catherine J Kommoss, Felix K F Koziak, Jennifer M Kraemer, Bernhard Le, Nhu D Lesnock, Jaime Lester, Jenny Lubiński, Jan Menkiszak, Janusz Ney, Britta Olawaiye, Alexander Orsulic, Sandra Osorio, Ana Robles-Díaz, Luis Ruebner, Matthias Shah, Mitul Sharma, Raghwa Shvetsov, Yurii B Steed, Helen Talhouk, Aline Taylor, Sarah E Traficante, Nadia Vierkant, Robert A Wang, Chen Wilkens, Lynne R Winham, Stacey J Benitez, Javier Berchuck, Andrew Bowtell, David D Candido Dos Reis, Francisco J Cook, Linda S DeFazio, Anna Doherty, Jennifer A Fasching, Peter A García, María J Goode, Ellen L Goodman, Marc T Gronwald, Jacek Huntsman, David G Karlan, Beth Y Kommoss, Stefan Modugno, Francesmary Schildkraut, Joellen M Sinn, Hans-Peter Staebler, Annette Kelemen, Linda E Ford, Caroline E Menon, Usha Pharoah, Paul D P Köbel, Martin Ramus, Susan J
author_role	author
author2	Kang, Eun-Young Meagher, Nicola S Nelson, Gregg S Ghatage, Prafull Lee, Cheng-Han Riggan, Marjorie J Gentry-Maharaj, Aleksandra Ryan, Andy Singh, Naveena Widschwendter, Martin Alsop, Jennifer Anglesio, Michael S Beckmann, Matthias W Berger, Jessica Bisinotto, Christiani Boros, Jessica Brand, Alison H Brenton, James D Brooks-Wilson, Angela Carney, Michael E Cunningham, Julie M Cushing-Haugen, Kara L Cybulski, Cezary Elishaev, Esther Erber, Ramona Fereday, Sian Fischer, Anna Paz Ares, Luis Gonzaga Gayarre, Javier Gilks, Blake C Grube, Marcel Harnett, Paul R Harris, Holly R Hartmann, Arndt Hein, Alexander Hendley, Joy Hernandez, Brenda Y Heublein, Sabine Huang, Yajue Huzarski, Tomasz Jakubowska, Anna Jimenez-Linan, Mercedes Kennedy, Catherine J Kommoss, Felix K F Koziak, Jennifer M Kraemer, Bernhard Le, Nhu D Lesnock, Jaime Lester, Jenny Lubiński, Jan Menkiszak, Janusz Ney, Britta Olawaiye, Alexander Orsulic, Sandra Osorio, Ana Robles-Díaz, Luis Ruebner, Matthias Shah, Mitul Sharma, Raghwa Shvetsov, Yurii B Steed, Helen Talhouk, Aline Taylor, Sarah E Traficante, Nadia Vierkant, Robert A Wang, Chen Wilkens, Lynne R Winham, Stacey J Benitez, Javier Berchuck, Andrew Bowtell, David D Candido Dos Reis, Francisco J Cook, Linda S DeFazio, Anna Doherty, Jennifer A Fasching, Peter A García, María J Goode, Ellen L Goodman, Marc T Gronwald, Jacek Huntsman, David G Karlan, Beth Y Kommoss, Stefan Modugno, Francesmary Schildkraut, Joellen M Sinn, Hans-Peter Staebler, Annette Kelemen, Linda E Ford, Caroline E Menon, Usha Pharoah, Paul D P Köbel, Martin Ramus, Susan J
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author
dc.contributor.none.fl_str_mv	United States Department of Health and Human Services Canadian Institutes of Health Research National Health and Medical Research Council (Australia) Instituto de Salud Carlos III Ministerio de Ciencia, Innovación y Universidades (España) Ovarian Cancer Research Foundation (Astrualia) American Cancer Society Deutsche Forschungsgemeinschaft (Alemania) Unión Europea Cancer Council Victoria (Australia) Fred C. and Katherine B. Andersen Foundation Heuer Stiftung fur medizinische Forschung
dc.subject.none.fl_str_mv	Ovarian Neoplasms Cystadenocarcinoma, Serous Humans Female Prognosis Survival Analysis RNA, Messenger Biomarkers, Tumor Forkhead Transcription Factors
topic	Ovarian Neoplasms Cystadenocarcinoma, Serous Humans Female Prognosis Survival Analysis RNA, Messenger Biomarkers, Tumor Forkhead Transcription Factors
description	BACKGROUND Recently, we showed a >60% difference in 5-year survival for patients with tubo-ovarian high-grade serous carcinoma (HGSC) when stratified by a 101-gene mRNA expression prognostic signature. Given the varied patient outcomes, this study aimed to translate prognostic mRNA markers into protein expression assays by immunohistochemistry and validate their survival association in HGSC. METHODS Two prognostic genes, FOXJ1 and GMNN, were selected based on high-quality antibodies, correlation with protein expression and variation in immunohistochemical scores in a preliminary cohort (n = 134 and n = 80, respectively). Six thousand four hundred and thirty-four (FOXJ1) and 5470 (GMNN) formalin-fixed, paraffin-embedded ovarian neoplasms (4634 and 4185 HGSC, respectively) represented on tissue microarrays from the Ovarian Tumor Tissue Analysis consortium underwent immunohistochemical staining and scoring, then univariate and multivariate survival analysis. RESULTS Consistent with mRNA, FOXJ1 protein expression exhibited a linear, increasing association with improved overall survival in HGSC patients. Women with >50% expression had the most favourable outcomes (HR = 0.78, 95% CI 0.67-0.91, p < 0.0001). GMNN protein expression was not significantly associated with overall HSGC patient survival. However, HGSCs with >35% GMNN expression showed a trend for better outcomes, though this was not significant. CONCLUSION We provide foundational evidence for the prognostic value of FOXJ1 in HGSC, validating the prior mRNA-based prognostic association by immunohistochemistry.
publishDate	2023
dc.date.none.fl_str_mv	2023 2023-01-01 2023 2023-01-01 2024 2024-03-08
dc.type.none.fl_str_mv	journal article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv	info:eu-repo/semantics/article
format	article
dc.identifier.none.fl_str_mv	http://hdl.handle.net/20.500.12105/18900
url	http://hdl.handle.net/20.500.12105/18900
dc.language.none.fl_str_mv	Inglés eng
language_invalid_str_mv	Inglés
language	eng
dc.relation.none.fl_str_mv	European Commission http://dx.doi.org/10.13039/501100000780 Horizon 2020 Framework Programme 742432
dc.rights.none.fl_str_mv	open access http://purl.org/coar/access_right/c_abf2 Attribution-NonCommercial-NoDerivatives 4.0 Internacional http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv	info:eu-repo/semantics/openAccess
rights_invalid_str_mv	open access http://purl.org/coar/access_right/c_abf2 Attribution-NonCommercial-NoDerivatives 4.0 Internacional http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf application/pdf application/vnd.openxmlformats-officedocument.wordprocessingml.document application/pdf application/pdf application/pdf
dc.publisher.none.fl_str_mv	Nature Publishing Group
publisher.none.fl_str_mv	Nature Publishing Group
dc.source.none.fl_str_mv	reponame:Repisalud instname:Instituto de Salud Carlos III (ISCIII)
instname_str	Instituto de Salud Carlos III (ISCIII)
reponame_str	Repisalud
collection	Repisalud
repository.name.fl_str_mv
repository.mail.fl_str_mv
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spelling	Increased FOXJ1 protein expression is associated with improved overall survival in high-grade serous ovarian carcinoma: an Ovarian Tumor Tissue Analysis Consortium Study.Weir, AshleyKang, Eun-YoungMeagher, Nicola SNelson, Gregg SGhatage, PrafullLee, Cheng-HanRiggan, Marjorie JGentry-Maharaj, AleksandraRyan, AndySingh, NaveenaWidschwendter, MartinAlsop, JenniferAnglesio, Michael SBeckmann, Matthias WBerger, JessicaBisinotto, ChristianiBoros, JessicaBrand, Alison HBrenton, James DBrooks-Wilson, AngelaCarney, Michael ECunningham, Julie MCushing-Haugen, Kara LCybulski, CezaryElishaev, EstherErber, RamonaFereday, SianFischer, AnnaPaz Ares, Luis GonzagaGayarre, JavierGilks, Blake CGrube, MarcelHarnett, Paul RHarris, Holly RHartmann, ArndtHein, AlexanderHendley, JoyHernandez, Brenda YHeublein, SabineHuang, YajueHuzarski, TomaszJakubowska, AnnaJimenez-Linan, MercedesKennedy, Catherine JKommoss, Felix K FKoziak, Jennifer MKraemer, BernhardLe, Nhu DLesnock, JaimeLester, JennyLubiński, JanMenkiszak, JanuszNey, BrittaOlawaiye, AlexanderOrsulic, SandraOsorio, AnaRobles-Díaz, LuisRuebner, MatthiasShah, MitulSharma, RaghwaShvetsov, Yurii BSteed, HelenTalhouk, AlineTaylor, Sarah ETraficante, NadiaVierkant, Robert AWang, ChenWilkens, Lynne RWinham, Stacey JBenitez, JavierBerchuck, AndrewBowtell, David DCandido Dos Reis, Francisco JCook, Linda SDeFazio, AnnaDoherty, Jennifer AFasching, Peter AGarcía, María JGoode, Ellen LGoodman, Marc TGronwald, JacekHuntsman, David GKarlan, Beth YKommoss, StefanModugno, FrancesmarySchildkraut, Joellen MSinn, Hans-PeterStaebler, AnnetteKelemen, Linda EFord, Caroline EMenon, UshaPharoah, Paul D PKöbel, MartinRamus, Susan JOvarian NeoplasmsCystadenocarcinoma, SerousHumansFemalePrognosisSurvival AnalysisRNA, MessengerBiomarkers, TumorForkhead Transcription FactorsBACKGROUND Recently, we showed a >60% difference in 5-year survival for patients with tubo-ovarian high-grade serous carcinoma (HGSC) when stratified by a 101-gene mRNA expression prognostic signature. Given the varied patient outcomes, this study aimed to translate prognostic mRNA markers into protein expression assays by immunohistochemistry and validate their survival association in HGSC. METHODS Two prognostic genes, FOXJ1 and GMNN, were selected based on high-quality antibodies, correlation with protein expression and variation in immunohistochemical scores in a preliminary cohort (n = 134 and n = 80, respectively). Six thousand four hundred and thirty-four (FOXJ1) and 5470 (GMNN) formalin-fixed, paraffin-embedded ovarian neoplasms (4634 and 4185 HGSC, respectively) represented on tissue microarrays from the Ovarian Tumor Tissue Analysis consortium underwent immunohistochemical staining and scoring, then univariate and multivariate survival analysis. RESULTS Consistent with mRNA, FOXJ1 protein expression exhibited a linear, increasing association with improved overall survival in HGSC patients. Women with >50% expression had the most favourable outcomes (HR = 0.78, 95% CI 0.67-0.91, p < 0.0001). GMNN protein expression was not significantly associated with overall HSGC patient survival. However, HGSCs with >35% GMNN expression showed a trend for better outcomes, though this was not significant. CONCLUSION We provide foundational evidence for the prognostic value of FOXJ1 in HGSC, validating the prior mRNA-based prognostic association by immunohistochemistry.Nature Publishing GroupUnited States Department of Health and Human ServicesCanadian Institutes of Health ResearchNational Health and Medical Research Council (Australia)Instituto de Salud Carlos IIIMinisterio de Ciencia, Innovación y Universidades (España)Ovarian Cancer Research Foundation (Astrualia)American Cancer SocietyDeutsche Forschungsgemeinschaft (Alemania)Unión EuropeaCancer Council Victoria (Australia)Fred C. and Katherine B. Andersen FoundationHeuer Stiftung fur medizinische Forschung20242024-03-0820232023-01-0120232023-01-01journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfapplication/pdfapplication/vnd.openxmlformats-officedocument.wordprocessingml.documentapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/20.500.12105/18900reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)InglésengEuropean Commission http://dx.doi.org/10.13039/501100000780 Horizon 2020 Framework Programme 742432open accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/189002026-06-12T12:43:37Z
score	15,812429

Increased FOXJ1 protein expression is associated with improved overall survival in high-grade serous ovarian carcinoma: an Ovarian Tumor Tissue Analysis Consortium Study.

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