Identification of atrial-enriched lncRNA Walras linked to cardiomyocyte cytoarchitecture and atrial fibrillation

Atrial fibrillation (AF) is the most prevalent cardiac arrhythmia in humans. Genetic and genomic analyses have recently demonstrated that the homeobox transcription factor Pitx2 plays a fundamental role regulating expression of distinct growth factors, microRNAs and ion channels leading to morpholog...

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Detalles Bibliográficos
Autores: García-Padilla, Carlos, Domínguez, Jorge N., Lodde, Valeria, Munk, Rachel, Abdelmohsen, Kotb, Gorospe, Myriam, Jiménez-Sábado, Verónica|||0000-0001-7720-988X, Ginel, Antonino|||0000-0002-8820-7545, Madsen, Leif Hove|||0000-0001-5493-3998, Aránega, Amelia|||0000-0002-0046-9410, Franco, Diego|||0000-0002-5669-7164
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:280902
Acceso en línea:https://ddd.uab.cat/record/280902
https://dx.doi.org/urn:doi:10.1096/fj.202100844RR
Access Level:acceso abierto
Palabra clave:Animals
Atrial Fibrillation
Cytoskeleton
Heart Atria
Humans
Lncrna
Mice
Mice, Knockout
Myocytes, Cardiac
Post-transcriptional regulation
RNA, Long Noncoding
Descripción
Sumario:Atrial fibrillation (AF) is the most prevalent cardiac arrhythmia in humans. Genetic and genomic analyses have recently demonstrated that the homeobox transcription factor Pitx2 plays a fundamental role regulating expression of distinct growth factors, microRNAs and ion channels leading to morphological and molecular alterations that promote the onset of AF. Here we address the plausible contribution of long non-coding (lnc)RNAs within the Pitx2.

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