Body weight of newborn and suckling piglets affects their intestinal gene expression
Modern hyperprolific sows must deal with large litters (16-20 piglets) which reduce piglet birthweight with a concomitant increase in the proportion of small and intrauterine growth retarded piglets. However, larger litters do not only have a greater variation of piglet weights, but also a greater v...
| Autores: | , , , , , |
|---|---|
| Formato: | artículo |
| Fecha de publicación: | 2022 |
| País: | España |
| Recursos: | Universitat Autònoma de Barcelona |
| Repositorio: | Dipòsit Digital de Documents de la UAB |
| Idioma: | inglés |
| OAI Identifier: | oai:ddd.uab.cat:269483 |
| Acesso em linha: | https://ddd.uab.cat/record/269483 https://dx.doi.org/urn:doi:10.1093/jas/skac161 |
| Access Level: | acceso abierto |
| Palavra-chave: | Birthweight Gene expression Hyperprolific sows Neonatal pigs Suckling pigs |
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Body weight of newborn and suckling piglets affects their intestinal gene expressionVillagómez Estrada, Sandra|||0000-0003-3086-3256Pérez Hernández, José Francisco|||0000-0001-8853-8945Melo Duran, Diego Alexander|||0000-0003-3944-1746González Solé, Francesc|||0000-0002-3469-6240D'angelo, MatildePérez Hernández, José Francisco|||0000-0001-8853-8945Solà Oriol, David|||0000-0001-8365-340XBirthweightGene expressionHyperprolific sowsNeonatal pigsSuckling pigsModern hyperprolific sows must deal with large litters (16-20 piglets) which reduce piglet birthweight with a concomitant increase in the proportion of small and intrauterine growth retarded piglets. However, larger litters do not only have a greater variation of piglet weights, but also a greater variation in colostrum and milk consumption within the litter. To further understand the impact that body weight has on piglets, the present study aimed to evaluate the degree of physiological weakness of the smallest piglets at birth and during the suckling period (20 d) compared to their middle-weight littermates through their jejunal gene expression. At birth, light piglets showed a downregulation of genes related to immune response (FAXDC2, HSPB1, PPARGC1α), antioxidant enzymes (SOD2m), digestive enzymes (ANPEP, IDO1, SI), and nutrient transporter (SLC39A4) (P < 0.05) but also a tendency for a higher mRNA expression of GBP1 (inflammatory regulator) and HSD11β1 (stress hormone) genes compared to their heavier littermates (P < 0.10). Excluding HSD11β1 gene, all these intestinal gene expression differences initially observed at birth between light and middle-weight piglets were stabilized at the end of the suckling period, when others appeared. Genes involved in barrier function (CLDN1), pro-inflammatory response (CXCL2, IL6, IDO1), and stress hormone signaling (HSD11β1) over-expressed compared to their middle-weight littermates (P < 0.05). In conclusion, at birth and at the end of suckling period, light body weight piglets seem to have a compromised gene expression and therefore impaired nutrient absorption, immune and stress responses compared to their heavier littermates. At birth and during lactation phase, the light body weight of piglets born from hyperprolific sows predisposed to a higher expression of stress and pro-inflammatory genes. 22022-01-0120222022-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/269483https://dx.doi.org/urn:doi:10.1093/jas/skac161reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2694832026-06-06T12:50:31Z |
| dc.title.none.fl_str_mv |
Body weight of newborn and suckling piglets affects their intestinal gene expression |
| title |
Body weight of newborn and suckling piglets affects their intestinal gene expression |
| spellingShingle |
Body weight of newborn and suckling piglets affects their intestinal gene expression Villagómez Estrada, Sandra|||0000-0003-3086-3256 Birthweight Gene expression Hyperprolific sows Neonatal pigs Suckling pigs |
| title_short |
Body weight of newborn and suckling piglets affects their intestinal gene expression |
| title_full |
Body weight of newborn and suckling piglets affects their intestinal gene expression |
| title_fullStr |
Body weight of newborn and suckling piglets affects their intestinal gene expression |
| title_full_unstemmed |
Body weight of newborn and suckling piglets affects their intestinal gene expression |
| title_sort |
Body weight of newborn and suckling piglets affects their intestinal gene expression |
| dc.creator.none.fl_str_mv |
Villagómez Estrada, Sandra|||0000-0003-3086-3256 Pérez Hernández, José Francisco|||0000-0001-8853-8945 Melo Duran, Diego Alexander|||0000-0003-3944-1746 González Solé, Francesc|||0000-0002-3469-6240 D'angelo, Matilde Pérez Hernández, José Francisco|||0000-0001-8853-8945 Solà Oriol, David|||0000-0001-8365-340X |
| author |
Villagómez Estrada, Sandra|||0000-0003-3086-3256 |
| author_facet |
Villagómez Estrada, Sandra|||0000-0003-3086-3256 Pérez Hernández, José Francisco|||0000-0001-8853-8945 Melo Duran, Diego Alexander|||0000-0003-3944-1746 González Solé, Francesc|||0000-0002-3469-6240 D'angelo, Matilde Solà Oriol, David|||0000-0001-8365-340X |
| author_role |
author |
| author2 |
Pérez Hernández, José Francisco|||0000-0001-8853-8945 Melo Duran, Diego Alexander|||0000-0003-3944-1746 González Solé, Francesc|||0000-0002-3469-6240 D'angelo, Matilde Solà Oriol, David|||0000-0001-8365-340X |
| author2_role |
author author author author author |
| dc.subject.none.fl_str_mv |
Birthweight Gene expression Hyperprolific sows Neonatal pigs Suckling pigs |
| topic |
Birthweight Gene expression Hyperprolific sows Neonatal pigs Suckling pigs |
| description |
Modern hyperprolific sows must deal with large litters (16-20 piglets) which reduce piglet birthweight with a concomitant increase in the proportion of small and intrauterine growth retarded piglets. However, larger litters do not only have a greater variation of piglet weights, but also a greater variation in colostrum and milk consumption within the litter. To further understand the impact that body weight has on piglets, the present study aimed to evaluate the degree of physiological weakness of the smallest piglets at birth and during the suckling period (20 d) compared to their middle-weight littermates through their jejunal gene expression. At birth, light piglets showed a downregulation of genes related to immune response (FAXDC2, HSPB1, PPARGC1α), antioxidant enzymes (SOD2m), digestive enzymes (ANPEP, IDO1, SI), and nutrient transporter (SLC39A4) (P < 0.05) but also a tendency for a higher mRNA expression of GBP1 (inflammatory regulator) and HSD11β1 (stress hormone) genes compared to their heavier littermates (P < 0.10). Excluding HSD11β1 gene, all these intestinal gene expression differences initially observed at birth between light and middle-weight piglets were stabilized at the end of the suckling period, when others appeared. Genes involved in barrier function (CLDN1), pro-inflammatory response (CXCL2, IL6, IDO1), and stress hormone signaling (HSD11β1) over-expressed compared to their middle-weight littermates (P < 0.05). In conclusion, at birth and at the end of suckling period, light body weight piglets seem to have a compromised gene expression and therefore impaired nutrient absorption, immune and stress responses compared to their heavier littermates. At birth and during lactation phase, the light body weight of piglets born from hyperprolific sows predisposed to a higher expression of stress and pro-inflammatory genes. |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2 2022-01-01 2022 2022-01-01 |
| dc.type.none.fl_str_mv |
Article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://ddd.uab.cat/record/269483 https://dx.doi.org/urn:doi:10.1093/jas/skac161 |
| url |
https://ddd.uab.cat/record/269483 https://dx.doi.org/urn:doi:10.1093/jas/skac161 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by-nc/4.0/ |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by-nc/4.0/ |
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openAccess |
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application/pdf |
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reponame:Dipòsit Digital de Documents de la UAB instname:Universitat Autònoma de Barcelona |
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Universitat Autònoma de Barcelona |
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Dipòsit Digital de Documents de la UAB |
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