Phytogenic Compounds Supplemented to Gestating Hyperprolific Sows Affects the Gut Health-Related Gene Expression and Histological Responses in Neonate Piglets

This research aims to determine whether a specific blend of phytogenic compounds (BPC) supplemented in gestating hyperprolific sow diets can promote prenatal maternal effects in terms of piglet gut function and morphology. Twenty-eight (Landrace × Yorkshire) gilts and sows (parity 0 to 7) were rando...

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Detalles Bibliográficos
Autores: Reyes-Camacho, David, Pérez Hernández, José Francisco|||0000-0001-8853-8945, Vinyeta, Ester, Aumiller, Tobias|||0000-0001-6836-0297, Criado Mesas, Lourdes|||0000-0002-1115-4131, Folch, Josep M|||0000-0003-3689-1303, Van der Klis, Jan Dirk, Solà Oriol, David|||0000-0001-8365-340X
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:256424
Acceso en línea:https://ddd.uab.cat/record/256424
https://dx.doi.org/urn:doi:10.3389/fvets.2021.639719
Access Level:acceso abierto
Palabra clave:Hyperprolific sows
Prenatal exposure
Neonatal programming
Phytogenic compounds
Piglet gut health
Descripción
Sumario:This research aims to determine whether a specific blend of phytogenic compounds (BPC) supplemented in gestating hyperprolific sow diets can promote prenatal maternal effects in terms of piglet gut function and morphology. Twenty-eight (Landrace × Yorkshire) gilts and sows (parity 0 to 7) were randomly distributed by parity number and body weight into two dietary treatments: unsupplemented Control (CON) (n = 14) or CON diet supplemented with 1 g/kg feed of BPC during gestation (n = 14). The BPC supplementation during gestation of sows downregulated the neonate piglets' jejunal genes involved in oxidation (SOD2) and nutrient transport (SLC16A1/MCT1, SLC11A2/DMT1, and SLC39A/ZIP4), while IFNG and CLDN4 related to immune response and barrier function, respectively, were upregulated (q < 0.10). In addition, the jejunal villus height and the ratio of the villus height to crypt depth tended to increase (p < 0.10), while goblet cell volume density was higher (p < 0.05) in BPC compared to CON. In conclusion, dietary supplementation of BPC in gestating diets for hyperprolific sows influences neonatal histomorphology and expression of genes related to the intestinal function and health.

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