Characteristics of patients with heart failure and advanced chronic kidney disease (Stages 4–5) not undergoing renal replacement therapy (ERCA-IC Study)

Valdivielso Moré, Sandra; Vicente Elcano, Miren; García Alonso, Anna; Pascual Sanchez, Sergi; Galceran Herrera, Isabel; Barbosa Puig, Francisco; Belarte Tornero, Laia Carla; Ruiz-Bustillo, Sonia; Morales Murillo, Ronald Octavio; Barrios Barrera, Clara; Vime-Jubany, Joan; Farré López, Núria

Characteristics of patients with heart failure and advanced chronic kidney disease (Stages 4–5) not undergoing renal replacement therapy (ERCA-IC Study)

Despite the frequent coexistence of heart failure (HF) in patients with advanced chronic kidney disease (CKD), it has been understudied, and little is known about its prevalence and prognostic relevance. A retrospective study of 217 patients with advanced CKD (stages 4 and 5) who did not undergo ren...

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Autores:	Valdivielso Moré, Sandra, Vicente Elcano, Miren, García Alonso, Anna, Pascual Sanchez, Sergi, Galceran Herrera, Isabel, Barbosa Puig, Francisco, Belarte Tornero, Laia Carla, Ruiz-Bustillo, Sonia, Morales Murillo, Ronald Octavio, Barrios Barrera, Clara, Vime-Jubany, Joan, Farré López, Núria
Tipo de recurso:	artículo
Estado:	Versión publicada
Fecha de publicación:	2023
País:	España
Institución:	Universitat Pompeu Fabra
Repositorio:	Repositorio Digital de la UPF
OAI Identifier:	oai:repositori.upf.edu:10230/57254
Acceso en línea:	http://hdl.handle.net/10230/57254 http://dx.doi.org/10.3390/jcm12062339
Access Level:	acceso abierto
Palabra clave:	Advanced chronic kidney disease Cardiorenal Heart failure Kidney dysfunction Prognosis Mortality

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spelling	Characteristics of patients with heart failure and advanced chronic kidney disease (Stages 4–5) not undergoing renal replacement therapy (ERCA-IC Study)Valdivielso Moré, SandraVicente Elcano, MirenGarcía Alonso, AnnaPascual Sanchez, SergiGalceran Herrera, IsabelBarbosa Puig, FranciscoBelarte Tornero, Laia CarlaRuiz-Bustillo, SoniaMorales Murillo, Ronald OctavioBarrios Barrera, ClaraVime-Jubany, JoanFarré López, NúriaAdvanced chronic kidney diseaseCardiorenalHeart failureKidney dysfunctionPrognosisMortalityDespite the frequent coexistence of heart failure (HF) in patients with advanced chronic kidney disease (CKD), it has been understudied, and little is known about its prevalence and prognostic relevance. A retrospective study of 217 patients with advanced CKD (stages 4 and 5) who did not undergo renal replacement therapy (RRT). The patients were followed up for two years. The primary outcome was all-cause death or the need for RRT. Forty percent of patients had a history of HF. The mean age was 78.2 ± 8.8 years and the mean eGFR was 18.4 ± 5.5 mL/min/1.73 m2. The presence of previous HF identified a subgroup of high-risk patients with a high prevalence of cardiovascular comorbidities and was significantly associated with the composite endpoint of all-cause hospitalization or need for RRT (66.7% vs. 53.1%, HR 95% CI 1.62 (1.04–2.52), p = 0.034). No differences were found in the need for RRT (27.6% vs. 32.2%, p = 0.46). Nineteen patients without HF at baseline developed HF during the follow-up and all-cause death was numerically higher (36.8 vs. 19.8%, p = 0.1). Patients with advanced CKD have a high prevalence of HF. The presence of previous HF identified a high-risk population with a worse prognosis that required close follow-up.MDPI202320232023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/57254http://dx.doi.org/10.3390/jcm12062339reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésJournal of Clinical Medicine. 2023 Mar 2;12(6):2339© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/572542026-06-12T07:21:37Z
dc.title.none.fl_str_mv	Characteristics of patients with heart failure and advanced chronic kidney disease (Stages 4–5) not undergoing renal replacement therapy (ERCA-IC Study)
title	Characteristics of patients with heart failure and advanced chronic kidney disease (Stages 4–5) not undergoing renal replacement therapy (ERCA-IC Study)
spellingShingle	Characteristics of patients with heart failure and advanced chronic kidney disease (Stages 4–5) not undergoing renal replacement therapy (ERCA-IC Study) Valdivielso Moré, Sandra Advanced chronic kidney disease Cardiorenal Heart failure Kidney dysfunction Prognosis Mortality
title_short	Characteristics of patients with heart failure and advanced chronic kidney disease (Stages 4–5) not undergoing renal replacement therapy (ERCA-IC Study)
title_full	Characteristics of patients with heart failure and advanced chronic kidney disease (Stages 4–5) not undergoing renal replacement therapy (ERCA-IC Study)
title_fullStr	Characteristics of patients with heart failure and advanced chronic kidney disease (Stages 4–5) not undergoing renal replacement therapy (ERCA-IC Study)
title_full_unstemmed	Characteristics of patients with heart failure and advanced chronic kidney disease (Stages 4–5) not undergoing renal replacement therapy (ERCA-IC Study)
title_sort	Characteristics of patients with heart failure and advanced chronic kidney disease (Stages 4–5) not undergoing renal replacement therapy (ERCA-IC Study)
dc.creator.none.fl_str_mv	Valdivielso Moré, Sandra Vicente Elcano, Miren García Alonso, Anna Pascual Sanchez, Sergi Galceran Herrera, Isabel Barbosa Puig, Francisco Belarte Tornero, Laia Carla Ruiz-Bustillo, Sonia Morales Murillo, Ronald Octavio Barrios Barrera, Clara Vime-Jubany, Joan Farré López, Núria
author	Valdivielso Moré, Sandra
author_facet	Valdivielso Moré, Sandra Vicente Elcano, Miren García Alonso, Anna Pascual Sanchez, Sergi Galceran Herrera, Isabel Barbosa Puig, Francisco Belarte Tornero, Laia Carla Ruiz-Bustillo, Sonia Morales Murillo, Ronald Octavio Barrios Barrera, Clara Vime-Jubany, Joan Farré López, Núria
author_role	author
author2	Vicente Elcano, Miren García Alonso, Anna Pascual Sanchez, Sergi Galceran Herrera, Isabel Barbosa Puig, Francisco Belarte Tornero, Laia Carla Ruiz-Bustillo, Sonia Morales Murillo, Ronald Octavio Barrios Barrera, Clara Vime-Jubany, Joan Farré López, Núria
author2_role	author author author author author author author author author author author
dc.subject.none.fl_str_mv	Advanced chronic kidney disease Cardiorenal Heart failure Kidney dysfunction Prognosis Mortality
topic	Advanced chronic kidney disease Cardiorenal Heart failure Kidney dysfunction Prognosis Mortality
description	Despite the frequent coexistence of heart failure (HF) in patients with advanced chronic kidney disease (CKD), it has been understudied, and little is known about its prevalence and prognostic relevance. A retrospective study of 217 patients with advanced CKD (stages 4 and 5) who did not undergo renal replacement therapy (RRT). The patients were followed up for two years. The primary outcome was all-cause death or the need for RRT. Forty percent of patients had a history of HF. The mean age was 78.2 ± 8.8 years and the mean eGFR was 18.4 ± 5.5 mL/min/1.73 m2. The presence of previous HF identified a subgroup of high-risk patients with a high prevalence of cardiovascular comorbidities and was significantly associated with the composite endpoint of all-cause hospitalization or need for RRT (66.7% vs. 53.1%, HR 95% CI 1.62 (1.04–2.52), p = 0.034). No differences were found in the need for RRT (27.6% vs. 32.2%, p = 0.46). Nineteen patients without HF at baseline developed HF during the follow-up and all-cause death was numerically higher (36.8 vs. 19.8%, p = 0.1). Patients with advanced CKD have a high prevalence of HF. The presence of previous HF identified a high-risk population with a worse prognosis that required close follow-up.
publishDate	2023
dc.date.none.fl_str_mv	2023 2023 2023
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	http://hdl.handle.net/10230/57254 http://dx.doi.org/10.3390/jcm12062339
url	http://hdl.handle.net/10230/57254 http://dx.doi.org/10.3390/jcm12062339
dc.language.none.fl_str_mv	Inglés
language_invalid_str_mv	Inglés
dc.relation.none.fl_str_mv	Journal of Clinical Medicine. 2023 Mar 2;12(6):2339
dc.rights.none.fl_str_mv	http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess
rights_invalid_str_mv	http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf application/pdf
dc.publisher.none.fl_str_mv	MDPI
publisher.none.fl_str_mv	MDPI
dc.source.none.fl_str_mv	reponame:Repositorio Digital de la UPF instname:Universitat Pompeu Fabra
instname_str	Universitat Pompeu Fabra
reponame_str	Repositorio Digital de la UPF
collection	Repositorio Digital de la UPF
repository.name.fl_str_mv
repository.mail.fl_str_mv
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Characteristics of patients with heart failure and advanced chronic kidney disease (Stages 4–5) not undergoing renal replacement therapy (ERCA-IC Study)

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