Bifidobacterium breve M-16 V and scGOS/lcFOS Supplementation to Dams Ameliorates Infant Rotavirus Infection in Early Life

The immune system of newborns is underdeveloped, leaving them susceptible to infections like rotavirus (RV). Despite vaccines, RV remains a leading cause of child mortality, especially in developing countries. Maternal immunity is transferred during pregnancy and breastfeeding to the offspring provi...

Descripción completa

Detalles Bibliográficos
Autores: Sáez Fuertes, Laura, Rio-Aige, Karla, Massot Cladera, Malen, Castell, Margarida, Knipping, K., Garssen, J., Bourdet-Sicard, Raphaëlle, Rodríguez Lagunas, María José, Collado, Maria Carmen, Pérez-Cano, Francisco J.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:dnet:ubarcelona__::cd0a708cc3c86224c1f32f114f152722
Acceso en línea:https://hdl.handle.net/2445/229693
Access Level:acceso abierto
Palabra clave:Sistema immunitari
Malalties neonatals
Mortalitat infantil
Expressió gènica
Immune system
Neonatal diseases
Infant mortality
Gene expression
id ES_2d2c26ca39d9bbe10063da5535f64e81
oai_identifier_str oai:dnet:ubarcelona__::cd0a708cc3c86224c1f32f114f152722
network_acronym_str ES
network_name_str España
repository_id_str
spelling Bifidobacterium breve M-16 V and scGOS/lcFOS Supplementation to Dams Ameliorates Infant Rotavirus Infection in Early LifeSáez Fuertes, LauraRio-Aige, KarlaMassot Cladera, MalenCastell, MargaridaKnipping, K.Garssen, J.Bourdet-Sicard, RaphaëlleRodríguez Lagunas, María JoséCollado, Maria CarmenPérez-Cano, Francisco J.Sistema immunitariMalalties neonatalsMortalitat infantilExpressió gènicaImmune systemNeonatal diseasesInfant mortalityGene expressionThe immune system of newborns is underdeveloped, leaving them susceptible to infections like rotavirus (RV). Despite vaccines, RV remains a leading cause of child mortality, especially in developing countries. Maternal immunity is transferred during pregnancy and breastfeeding to the offspring providing protection against RV infection. This study aims to explore how the maternal diet can enhance the newborn’s ability to fight early infections. Pregnant rats received orally Bifidobacterium breve M-16 V and short chain galacto-oligosaccharides (scGOS)/long chain fructo-oligosaccharides (lcFOS). At day 5 of life pups are infected with RV and at day 8, samples are collected for the infection analysis. Pups whose mothers received the synbiotic have lower RV infection severity. The levels of immunoglobulins (Ig) IgG2c and IgA are raised in pups’ plasma and digested milk, respectively. Synbiotic supplementation improves intestinal maturation and increases gene expression of immune-related genes. In conclusion, the administration of this synbiotic to gestating and lactating mothers ameliorates the incidence and severity of the pup’s diarrhea caused by the RV infection by improving their immunity.Wiley-VCH2024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/229693reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1002/mnfr.202400377Molecular Nutrition & Food Research, 2024, vol. 68, num.22, p. 2400377https://doi.org/10.1002/mnfr.202400377cc-by-nc-nd (c) Sáez Fuertes, Laura et al., 2024https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:dnet:ubarcelona__::cd0a708cc3c86224c1f32f114f1527222026-05-27T06:46:51Z
dc.title.none.fl_str_mv Bifidobacterium breve M-16 V and scGOS/lcFOS Supplementation to Dams Ameliorates Infant Rotavirus Infection in Early Life
title Bifidobacterium breve M-16 V and scGOS/lcFOS Supplementation to Dams Ameliorates Infant Rotavirus Infection in Early Life
spellingShingle Bifidobacterium breve M-16 V and scGOS/lcFOS Supplementation to Dams Ameliorates Infant Rotavirus Infection in Early Life
Sáez Fuertes, Laura
Sistema immunitari
Malalties neonatals
Mortalitat infantil
Expressió gènica
Immune system
Neonatal diseases
Infant mortality
Gene expression
title_short Bifidobacterium breve M-16 V and scGOS/lcFOS Supplementation to Dams Ameliorates Infant Rotavirus Infection in Early Life
title_full Bifidobacterium breve M-16 V and scGOS/lcFOS Supplementation to Dams Ameliorates Infant Rotavirus Infection in Early Life
title_fullStr Bifidobacterium breve M-16 V and scGOS/lcFOS Supplementation to Dams Ameliorates Infant Rotavirus Infection in Early Life
title_full_unstemmed Bifidobacterium breve M-16 V and scGOS/lcFOS Supplementation to Dams Ameliorates Infant Rotavirus Infection in Early Life
title_sort Bifidobacterium breve M-16 V and scGOS/lcFOS Supplementation to Dams Ameliorates Infant Rotavirus Infection in Early Life
dc.creator.none.fl_str_mv Sáez Fuertes, Laura
Rio-Aige, Karla
Massot Cladera, Malen
Castell, Margarida
Knipping, K.
Garssen, J.
Bourdet-Sicard, Raphaëlle
Rodríguez Lagunas, María José
Collado, Maria Carmen
Pérez-Cano, Francisco J.
author Sáez Fuertes, Laura
author_facet Sáez Fuertes, Laura
Rio-Aige, Karla
Massot Cladera, Malen
Castell, Margarida
Knipping, K.
Garssen, J.
Bourdet-Sicard, Raphaëlle
Rodríguez Lagunas, María José
Collado, Maria Carmen
Pérez-Cano, Francisco J.
author_role author
author2 Rio-Aige, Karla
Massot Cladera, Malen
Castell, Margarida
Knipping, K.
Garssen, J.
Bourdet-Sicard, Raphaëlle
Rodríguez Lagunas, María José
Collado, Maria Carmen
Pérez-Cano, Francisco J.
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Sistema immunitari
Malalties neonatals
Mortalitat infantil
Expressió gènica
Immune system
Neonatal diseases
Infant mortality
Gene expression
topic Sistema immunitari
Malalties neonatals
Mortalitat infantil
Expressió gènica
Immune system
Neonatal diseases
Infant mortality
Gene expression
description The immune system of newborns is underdeveloped, leaving them susceptible to infections like rotavirus (RV). Despite vaccines, RV remains a leading cause of child mortality, especially in developing countries. Maternal immunity is transferred during pregnancy and breastfeeding to the offspring providing protection against RV infection. This study aims to explore how the maternal diet can enhance the newborn’s ability to fight early infections. Pregnant rats received orally Bifidobacterium breve M-16 V and short chain galacto-oligosaccharides (scGOS)/long chain fructo-oligosaccharides (lcFOS). At day 5 of life pups are infected with RV and at day 8, samples are collected for the infection analysis. Pups whose mothers received the synbiotic have lower RV infection severity. The levels of immunoglobulins (Ig) IgG2c and IgA are raised in pups’ plasma and digested milk, respectively. Synbiotic supplementation improves intestinal maturation and increases gene expression of immune-related genes. In conclusion, the administration of this synbiotic to gestating and lactating mothers ameliorates the incidence and severity of the pup’s diarrhea caused by the RV infection by improving their immunity.
publishDate 2024
dc.date.none.fl_str_mv 2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/229693
url https://hdl.handle.net/2445/229693
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1002/mnfr.202400377
Molecular Nutrition & Food Research, 2024, vol. 68, num.22, p. 2400377
https://doi.org/10.1002/mnfr.202400377
dc.rights.none.fl_str_mv cc-by-nc-nd (c) Sáez Fuertes, Laura et al., 2024
https://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by-nc-nd (c) Sáez Fuertes, Laura et al., 2024
https://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley-VCH
publisher.none.fl_str_mv Wiley-VCH
dc.source.none.fl_str_mv reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869405296976199680
score 15,812429

Similares en LA Referencia