Bifidobacterium breve M-16 V and scGOS/lcFOS Supplementation to Dams Ameliorates Infant Rotavirus Infection in Early Life

The immune system of newborns is underdeveloped, leaving them susceptible to infections like rotavirus (RV). Despite vaccines, RV remains a leading cause of child mortality, especially in developing countries. Maternal immunity is transferred during pregnancy and breastfeeding to the offspring provi...

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Detalles Bibliográficos
Autores: Sáez Fuertes, Laura, Rio-Aige, Karla, Massot Cladera, Malen, Castell, Margarida, Knipping, K., Garssen, J., Bourdet-Sicard, Raphaëlle, Rodríguez Lagunas, María José, Collado, Maria Carmen, Pérez-Cano, Francisco J.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:dnet:ubarcelona__::cd0a708cc3c86224c1f32f114f152722
Acceso en línea:https://hdl.handle.net/2445/229693
Access Level:acceso abierto
Palabra clave:Sistema immunitari
Malalties neonatals
Mortalitat infantil
Expressió gènica
Immune system
Neonatal diseases
Infant mortality
Gene expression
Descripción
Sumario:The immune system of newborns is underdeveloped, leaving them susceptible to infections like rotavirus (RV). Despite vaccines, RV remains a leading cause of child mortality, especially in developing countries. Maternal immunity is transferred during pregnancy and breastfeeding to the offspring providing protection against RV infection. This study aims to explore how the maternal diet can enhance the newborn’s ability to fight early infections. Pregnant rats received orally Bifidobacterium breve M-16 V and short chain galacto-oligosaccharides (scGOS)/long chain fructo-oligosaccharides (lcFOS). At day 5 of life pups are infected with RV and at day 8, samples are collected for the infection analysis. Pups whose mothers received the synbiotic have lower RV infection severity. The levels of immunoglobulins (Ig) IgG2c and IgA are raised in pups’ plasma and digested milk, respectively. Synbiotic supplementation improves intestinal maturation and increases gene expression of immune-related genes. In conclusion, the administration of this synbiotic to gestating and lactating mothers ameliorates the incidence and severity of the pup’s diarrhea caused by the RV infection by improving their immunity.

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