Short pulsed microwave ablation: computer modeling and ex vivo experiments

Purpose: To study the differences between continuous and short-pulse mode microwave ablation (MWA). Methods: We built a computational model for MWA including a 200 mm long and 14 G antenna from Amica-Gen and solved an electromagnetic-thermal coupled problem using COMSOL Multiphysics. We compared the...

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Autores: Radosevic, Aleksandar, 1974-, Prieto, Diego, Burdío Pinilla, Fernando, Berjano, Enrique J., Prakash, Punit, Trujillo Guillén, Macarena
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2021
País:España
Recursos:Universitat Pompeu Fabra
Repositório:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/47943
Acesso em linha:http://hdl.handle.net/10230/47943
http://dx.doi.org/10.1080/02656736.2021.1894358
Access Level:Acceso aberto
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spelling Short pulsed microwave ablation: computer modeling and ex vivo experimentsRadosevic, Aleksandar, 1974-Prieto, DiegoBurdío Pinilla, FernandoBerjano, Enrique J.Prakash, PunitTrujillo Guillén, MacarenaPurpose: To study the differences between continuous and short-pulse mode microwave ablation (MWA). Methods: We built a computational model for MWA including a 200 mm long and 14 G antenna from Amica-Gen and solved an electromagnetic-thermal coupled problem using COMSOL Multiphysics. We compared the coagulation zone (CZ) sizes created with pulsed and continuous modes under ex vivo and in vivo conditions. The model was used to compare long vs. short pulses, and 1000 W high-powered short pulses. Ex vivo experiments were conducted to validate the model. Results: The computational models predicted the axial diameter of the CZ with an error of 2-3% and overestimated the transverse diameter by 9-11%. For short pulses, the ex vivo computer modeling results showed a trend toward larger CZ when duty cycles decreases. In general, short pulsed mode yielded higher CZ diameters and volumes than continuous mode, but the differences were not significant (<5%), as in terms of CZ sphericity. The same trends were observed in the simulations mimicking in vivo conditions. Both CZ diameter and sphericity were similar with short and long pulses. Short 1000 W pulses produced smaller sphericity and similar CZ sizes under in vivo and ex vivo conditions. Conclusions: The characteristics of the CZ created by continuous and pulsed MWA show no significant differences from ex vivo experiments and computer simulations. The proposed idea of enlarging coagulation zones and improving their sphericity in pulsed mode was not evident in this study.This work was supported by the Spanish Ministerio de Ciencia, Innovación y Universidades under ‘Programa Estatal de I + D + i Orientada a los Retos de la Sociedad’, Grant N° RTI2018-094357-B-C21.Taylor & Francis202120212021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/47943http://dx.doi.org/10.1080/02656736.2021.1894358reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésInt J Hyperthermia. 2021;38(1):409-20info:eu-repo/grantAgreement/ES/2PE/RTI2018-094357-B-C21© 2021 The Author(s). Published with license by Taylor & Francis Group, LLCThis is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use,distribution, and reproduction in any medium, provided the original work is properly cited.http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/479432026-06-12T07:21:37Z
dc.title.none.fl_str_mv Short pulsed microwave ablation: computer modeling and ex vivo experiments
title Short pulsed microwave ablation: computer modeling and ex vivo experiments
spellingShingle Short pulsed microwave ablation: computer modeling and ex vivo experiments
Radosevic, Aleksandar, 1974-
title_short Short pulsed microwave ablation: computer modeling and ex vivo experiments
title_full Short pulsed microwave ablation: computer modeling and ex vivo experiments
title_fullStr Short pulsed microwave ablation: computer modeling and ex vivo experiments
title_full_unstemmed Short pulsed microwave ablation: computer modeling and ex vivo experiments
title_sort Short pulsed microwave ablation: computer modeling and ex vivo experiments
dc.creator.none.fl_str_mv Radosevic, Aleksandar, 1974-
Prieto, Diego
Burdío Pinilla, Fernando
Berjano, Enrique J.
Prakash, Punit
Trujillo Guillén, Macarena
author Radosevic, Aleksandar, 1974-
author_facet Radosevic, Aleksandar, 1974-
Prieto, Diego
Burdío Pinilla, Fernando
Berjano, Enrique J.
Prakash, Punit
Trujillo Guillén, Macarena
author_role author
author2 Prieto, Diego
Burdío Pinilla, Fernando
Berjano, Enrique J.
Prakash, Punit
Trujillo Guillén, Macarena
author2_role author
author
author
author
author
description Purpose: To study the differences between continuous and short-pulse mode microwave ablation (MWA). Methods: We built a computational model for MWA including a 200 mm long and 14 G antenna from Amica-Gen and solved an electromagnetic-thermal coupled problem using COMSOL Multiphysics. We compared the coagulation zone (CZ) sizes created with pulsed and continuous modes under ex vivo and in vivo conditions. The model was used to compare long vs. short pulses, and 1000 W high-powered short pulses. Ex vivo experiments were conducted to validate the model. Results: The computational models predicted the axial diameter of the CZ with an error of 2-3% and overestimated the transverse diameter by 9-11%. For short pulses, the ex vivo computer modeling results showed a trend toward larger CZ when duty cycles decreases. In general, short pulsed mode yielded higher CZ diameters and volumes than continuous mode, but the differences were not significant (<5%), as in terms of CZ sphericity. The same trends were observed in the simulations mimicking in vivo conditions. Both CZ diameter and sphericity were similar with short and long pulses. Short 1000 W pulses produced smaller sphericity and similar CZ sizes under in vivo and ex vivo conditions. Conclusions: The characteristics of the CZ created by continuous and pulsed MWA show no significant differences from ex vivo experiments and computer simulations. The proposed idea of enlarging coagulation zones and improving their sphericity in pulsed mode was not evident in this study.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/47943
http://dx.doi.org/10.1080/02656736.2021.1894358
url http://hdl.handle.net/10230/47943
http://dx.doi.org/10.1080/02656736.2021.1894358
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Int J Hyperthermia. 2021;38(1):409-20
info:eu-repo/grantAgreement/ES/2PE/RTI2018-094357-B-C21
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Taylor & Francis
publisher.none.fl_str_mv Taylor & Francis
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
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repository.mail.fl_str_mv
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