Microwave versus radiofrequency ablation for the treatment of liver malignancies: a randomized controlled phase 2 trial

Microwave (MWA) and radiofrequency ablation (RFA) are main ablative techniques for hepatocellular carcinoma (HCC) and colorectal liver metastasis (MT). This randomized phase 2 clinical trial compares the effectiveness of MWA and RFA as well as morphology of corresponding ablation zones. HCC and MT p...

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Detalles Bibliográficos
Autores: Radosevic, Aleksandar, 1974-, Quesada Diez, Rita, Serlavos, Clara, Sánchez, Juan, Zugazaga Cortázar, Ander, Sierra, Ana, Coll Estrada, Susanna, Busto Barrera, Marcos, Aguilar, Guadalupe, Flores Pereyra, Daniel, Arce, Javier, Maiques Llácer, José María, García Retortillo, Montserrat, Carrión Rodríguez, José Antonio, Visa Turmo, Laura, Villamonte, Maria, Pueyo Périz, Eva M., Sánchez Velázquez, Patricia, 1985-, Grande Posa, Luís, Burdío Pinilla, Fernando
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Universitat Pompeu Fabra
Repositorio:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/54482
Acceso en línea:http://hdl.handle.net/10230/54482
http://dx.doi.org/10.1038/s41598-021-03802-x
Access Level:acceso abierto
Palabra clave:Cancer therapy
Clinical trials
Randomized controlled trials
Descripción
Sumario:Microwave (MWA) and radiofrequency ablation (RFA) are main ablative techniques for hepatocellular carcinoma (HCC) and colorectal liver metastasis (MT). This randomized phase 2 clinical trial compares the effectiveness of MWA and RFA as well as morphology of corresponding ablation zones. HCC and MT patients with 1.5-4 cm tumors, suitable for ablation, were randomized into MWA or RFA Groups. The primary endpoint was short-to-long diameter ratio of ablation zone (SLR). Primary technical success (TS) and a cumulative local tumor progression (LTP) after a median 2-year follow-up were compared. Between June 2015 and April 2020, 82 patients were randomly assigned (41 patients per group). For the per-protocol analysis, five patients were excluded. MWA created larger ablation zones than RFA (p = 0.036) although without differences in SLR (0.5 for both groups, p = 0.229). The TS was achieved in 98% (46/47) and 90% (45/50) (p = 0.108), and LTP was observed in 21% (10/47) vs. 12% (6/50) (OR 1.9 [95% CI 0.66-5.3], p = 0.238) of tumors in MWA vs. RFA Group, respectively. Major complications were found in 5 cases (11%) vs. 2 cases (4%), without statistical significance. MWA and RFA show similar SLR, effectiveness and safety in liver tumors between 1.5 and 4 cm.

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