Complexity changes in preclinical Alzheimer’s disease: An MEG study of subjective cognitive decline and mild cognitive impairment

Objective To analyse magnetoencephalogram (MEG) signals with Lempel-Ziv Complexity (LZC) to identify the regions of the brain showing changes related to cognitive decline and Alzheimeŕs Disease (AD). Methods LZC was used to study MEG signals in the source space from 99 participants (36 male, 63 fema...

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Autores: Shumbayawonda, Elizabeth, López Sanz, David, Bruña Fernández, Ricardo, Serrano Martínez, Noelia, Fernández Lucas, Alberto Amable, Maestu Unturbe, Fernando, Abásolo, Daniel
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/94979
Acceso en línea:https://hdl.handle.net/20.500.14352/94979
Access Level:acceso abierto
Palabra clave:Lempel-Ziv complexity
Magnetoencephalogram
Subjective cognitive decline
Mild cognitive impairment
Source space
Alzheimer’s disease
Psicología experimental
6106.01 Actividad Cerebral
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spelling Complexity changes in preclinical Alzheimer’s disease: An MEG study of subjective cognitive decline and mild cognitive impairmentShumbayawonda, ElizabethLópez Sanz, DavidBruña Fernández, RicardoSerrano Martínez, NoeliaFernández Lucas, Alberto AmableMaestu Unturbe, FernandoAbásolo, DanielLempel-Ziv complexityMagnetoencephalogramSubjective cognitive declineMild cognitive impairmentSource spaceAlzheimer’s diseasePsicología experimental6106.01 Actividad CerebralObjective To analyse magnetoencephalogram (MEG) signals with Lempel-Ziv Complexity (LZC) to identify the regions of the brain showing changes related to cognitive decline and Alzheimeŕs Disease (AD). Methods LZC was used to study MEG signals in the source space from 99 participants (36 male, 63 female, average age: 71.82 ± 4.06) in three groups (33 subjects per group): healthy (control) older adults, older adults with subjective cognitive decline (SCD), and adults with mild cognitive impairment (MCI). Analyses were performed in broadband (2–45 Hz) and in classic narrow bands (theta (4–8 Hz), alpha (8–12 Hz), low beta (12–20 Hz), high beta (20–30 Hz), and, gamma (30–45 Hz)). Results LZC was significantly lower in subjects with MCI than in those with SCD. Moreover, subjects with MCI had significantly lower MEG complexity than controls and SCD subjects in the beta frequency band. Lower complexity was correlated with smaller hippocampal volumes. Conclusions Brain complexity – measured with LZC – decreases in MCI patients when compared to SCD and healthy controls. This decrease is associated with a decrease in hippocampal volume, a key feature in AD progression. Significance This is the first study to date characterising the changes of brain activity complexity showing the specific spatial pattern of the alterations as well as the morphological correlations throughout preclinical stages of AD.ElsevierUniversidad Complutense de Madrid20202020-02-0120202020-02-01journal articlehttp://purl.org/coar/resource_type/c_6501AMhttp://purl.org/coar/version/c_ab4af688f83e57aainfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/94979reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/949792026-06-02T12:44:21Z
dc.title.none.fl_str_mv Complexity changes in preclinical Alzheimer’s disease: An MEG study of subjective cognitive decline and mild cognitive impairment
title Complexity changes in preclinical Alzheimer’s disease: An MEG study of subjective cognitive decline and mild cognitive impairment
spellingShingle Complexity changes in preclinical Alzheimer’s disease: An MEG study of subjective cognitive decline and mild cognitive impairment
Shumbayawonda, Elizabeth
Lempel-Ziv complexity
Magnetoencephalogram
Subjective cognitive decline
Mild cognitive impairment
Source space
Alzheimer’s disease
Psicología experimental
6106.01 Actividad Cerebral
title_short Complexity changes in preclinical Alzheimer’s disease: An MEG study of subjective cognitive decline and mild cognitive impairment
title_full Complexity changes in preclinical Alzheimer’s disease: An MEG study of subjective cognitive decline and mild cognitive impairment
title_fullStr Complexity changes in preclinical Alzheimer’s disease: An MEG study of subjective cognitive decline and mild cognitive impairment
title_full_unstemmed Complexity changes in preclinical Alzheimer’s disease: An MEG study of subjective cognitive decline and mild cognitive impairment
title_sort Complexity changes in preclinical Alzheimer’s disease: An MEG study of subjective cognitive decline and mild cognitive impairment
dc.creator.none.fl_str_mv Shumbayawonda, Elizabeth
López Sanz, David
Bruña Fernández, Ricardo
Serrano Martínez, Noelia
Fernández Lucas, Alberto Amable
Maestu Unturbe, Fernando
Abásolo, Daniel
author Shumbayawonda, Elizabeth
author_facet Shumbayawonda, Elizabeth
López Sanz, David
Bruña Fernández, Ricardo
Serrano Martínez, Noelia
Fernández Lucas, Alberto Amable
Maestu Unturbe, Fernando
Abásolo, Daniel
author_role author
author2 López Sanz, David
Bruña Fernández, Ricardo
Serrano Martínez, Noelia
Fernández Lucas, Alberto Amable
Maestu Unturbe, Fernando
Abásolo, Daniel
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv Lempel-Ziv complexity
Magnetoencephalogram
Subjective cognitive decline
Mild cognitive impairment
Source space
Alzheimer’s disease
Psicología experimental
6106.01 Actividad Cerebral
topic Lempel-Ziv complexity
Magnetoencephalogram
Subjective cognitive decline
Mild cognitive impairment
Source space
Alzheimer’s disease
Psicología experimental
6106.01 Actividad Cerebral
description Objective To analyse magnetoencephalogram (MEG) signals with Lempel-Ziv Complexity (LZC) to identify the regions of the brain showing changes related to cognitive decline and Alzheimeŕs Disease (AD). Methods LZC was used to study MEG signals in the source space from 99 participants (36 male, 63 female, average age: 71.82 ± 4.06) in three groups (33 subjects per group): healthy (control) older adults, older adults with subjective cognitive decline (SCD), and adults with mild cognitive impairment (MCI). Analyses were performed in broadband (2–45 Hz) and in classic narrow bands (theta (4–8 Hz), alpha (8–12 Hz), low beta (12–20 Hz), high beta (20–30 Hz), and, gamma (30–45 Hz)). Results LZC was significantly lower in subjects with MCI than in those with SCD. Moreover, subjects with MCI had significantly lower MEG complexity than controls and SCD subjects in the beta frequency band. Lower complexity was correlated with smaller hippocampal volumes. Conclusions Brain complexity – measured with LZC – decreases in MCI patients when compared to SCD and healthy controls. This decrease is associated with a decrease in hippocampal volume, a key feature in AD progression. Significance This is the first study to date characterising the changes of brain activity complexity showing the specific spatial pattern of the alterations as well as the morphological correlations throughout preclinical stages of AD.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-02-01
2020
2020-02-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
AM
http://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/94979
url https://hdl.handle.net/20.500.14352/94979
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.301603

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