T-cell immune profile in blood of systemic mastocytosis: Association with disease features

[Background]: Systemic mastocytosis (SM) is a heterogeneous disease characterized by an expansion of KIT-mutated mast cells (MC). KIT-mutated MC display activated features and release MC mediators that might act on the tumour microenvironment and other immune cells. Here, we investigated the distrib...

Descripción completa

Detalles Bibliográficos
Autores: Pérez-Pons, Alba, Teodosio, Cristina, Jara-Acevedo, Maria, Henriques, Ana, Navarro-Navarro, Paula, García-Montero, Andrés, Álvarez-Twose, Iván, Lécrevisse, Quentin, Fluxá, Rafael, Sánchez-Muñoz, Laura, Caldas, Carolina, Pozo, Julio, Martín, Silvia, Contreras-Sanfeliciano, Teresa, Pedreira, C. E., Botafogo, Vitor, González-López, Óscar, Mayado, Andrea, Orfao, Alberto
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/382038
Acceso en línea:http://hdl.handle.net/10261/382038
Access Level:acceso abierto
Palabra clave:Cytotoxic T cells
Helper T cells
Lymphocytes
Mast cells
Systemic mastocytosis
Descripción
Sumario:[Background]: Systemic mastocytosis (SM) is a heterogeneous disease characterized by an expansion of KIT-mutated mast cells (MC). KIT-mutated MC display activated features and release MC mediators that might act on the tumour microenvironment and other immune cells. Here, we investigated the distribution of lymphocyte subsets in blood of patients with distinct subtypes of SM and determined its association with other disease features.

Similares en LA Referencia