Lipid profile, cardiovascular disease and mortality in a Mediterranean high-risk population: The ESCARVAL-RISK study

Introduction: The potential impact of targeting different components of an adverse lipid profile in populations with multiple cardiovascular risk factors is not completely clear. This study aims to assess the association between different components of the standard lipid profile with all-cause morta...

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Autores: Orozco-Beltran, Domingo, Gil-Guillen, Vicente F, Redon, Josep, Martin-Moreno, Jose M, Pallarés-Carratalá, Vicente, Navarro-Perez, Jorge, Valls-Roca, Francisco, Sanchis-Domenech, Carlos, Fernandez-Gimenez, Antonio, Perez-Navarro, Ana, Bertomeu-Martinez, Vicente, Cordero, Alberto, Pascual de la Torre, Manuel, Trillo, Jose L, Carratala-Munuera, Concepcion, Pita-Fernandez, Salvador, Uso, Ruth, Durazo-Arvizu, Ramon, Cooper, Richard S, Sanz, Gines, Castellano, Jose Maria, Ascaso, Juan F, Carmena, Rafael, Tellez-Plaza, Maria
Formato: artículo
Fecha de publicación:2017
País:España
Recursos:Instituto de Salud Carlos III (ISCIII)
Repositorio:Repisalud
Idioma:inglés
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/13382
Acesso em linha:http://hdl.handle.net/20.500.12105/13382
Access Level:acceso abierto
Palavra-chave:Adult
Aged
Cardiovascular Diseases
Cholesterol, HDL
Cholesterol, LDL
Coronary Disease
Diabetes Mellitus
Female
Hospitalization
Humans
Hypertension
Lipids
Male
Middle Aged
Risk Factors
Stroke
Triglycerides
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oai_identifier_str oai:repisalud.isciii.es:20.500.12105/13382
network_acronym_str ES
network_name_str España
repository_id_str
spelling Lipid profile, cardiovascular disease and mortality in a Mediterranean high-risk population: The ESCARVAL-RISK studyOrozco-Beltran, DomingoGil-Guillen, Vicente FRedon, JosepMartin-Moreno, Jose MPallarés-Carratalá, VicenteNavarro-Perez, JorgeValls-Roca, FranciscoSanchis-Domenech, CarlosFernandez-Gimenez, AntonioPerez-Navarro, AnaBertomeu-Martinez, VicenteCordero, AlbertoPascual de la Torre, ManuelTrillo, Jose LCarratala-Munuera, ConcepcionPita-Fernandez, SalvadorUso, RuthDurazo-Arvizu, RamonCooper, Richard SSanz, GinesCastellano, Jose MariaAscaso, Juan FCarmena, RafaelTellez-Plaza, MariaAdultAgedCardiovascular DiseasesCholesterol, HDLCholesterol, LDLCoronary DiseaseDiabetes MellitusFemaleHospitalizationHumansHypertensionLipidsMaleMiddle AgedRisk FactorsStrokeTriglyceridesIntroduction: The potential impact of targeting different components of an adverse lipid profile in populations with multiple cardiovascular risk factors is not completely clear. This study aims to assess the association between different components of the standard lipid profile with all-cause mortality and hospitalization due to cardiovascular events in a high-risk population. Methods: This prospective registry included high risk adults over 30 years old free of cardiovascular disease (2008-2012). Diagnosis of hypertension, dyslipidemia or diabetes mellitus was inclusion criterion. Lipid biomarkers were evaluated. Primary endpoints were all-cause mortality and hospital admission due to coronary heart disease or stroke. We estimated adjusted rate ratios (aRR), absolute risk differences and population attributable risk associated with adverse lipid profiles. Results: 51,462 subjects were included with a mean age of 62.6 years (47.6% men). During an average follow-up of 3.2 years, 919 deaths, 1666 hospitalizations for coronary heart disease and 1510 hospitalizations for stroke were recorded. The parameters that showed an increased rate for total mortality, coronary heart disease and stroke hospitalization were, respectively, low HDL-Cholesterol: aRR 1.25, 1.29 and 1.23; high Total/HDL-Cholesterol: aRR 1.22, 1.38 and 1.25; and high Triglycerides/HDL-Cholesterol: aRR 1.21, 1.30, 1.09. The parameters that showed highest population attributable risk (%) were, respectively, low HDL-Cholesterol: 7.70, 11.42, 8.40; high Total/HDL-Cholesterol: 6.55, 12.47, 8.73; and high Triglycerides/HDL-Cholesterol: 8.94, 15.09, 6.92. Conclusions: In a population with cardiovascular risk factors, HDL-cholesterol, Total/HDL-cholesterol and triglycerides/HDL-cholesterol ratios were associated with a higher population attributable risk for cardiovascular disease compared to other common biomarkers.Public Library of Science (PLOS)20212021-09-1420172017-10-1820172017-10-18research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfapplication/octet-streamhttp://hdl.handle.net/20.500.12105/13382reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Atribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/133822026-06-12T12:43:37Z
dc.title.none.fl_str_mv Lipid profile, cardiovascular disease and mortality in a Mediterranean high-risk population: The ESCARVAL-RISK study
title Lipid profile, cardiovascular disease and mortality in a Mediterranean high-risk population: The ESCARVAL-RISK study
spellingShingle Lipid profile, cardiovascular disease and mortality in a Mediterranean high-risk population: The ESCARVAL-RISK study
Orozco-Beltran, Domingo
Adult
Aged
Cardiovascular Diseases
Cholesterol, HDL
Cholesterol, LDL
Coronary Disease
Diabetes Mellitus
Female
Hospitalization
Humans
Hypertension
Lipids
Male
Middle Aged
Risk Factors
Stroke
Triglycerides
title_short Lipid profile, cardiovascular disease and mortality in a Mediterranean high-risk population: The ESCARVAL-RISK study
title_full Lipid profile, cardiovascular disease and mortality in a Mediterranean high-risk population: The ESCARVAL-RISK study
title_fullStr Lipid profile, cardiovascular disease and mortality in a Mediterranean high-risk population: The ESCARVAL-RISK study
title_full_unstemmed Lipid profile, cardiovascular disease and mortality in a Mediterranean high-risk population: The ESCARVAL-RISK study
title_sort Lipid profile, cardiovascular disease and mortality in a Mediterranean high-risk population: The ESCARVAL-RISK study
dc.creator.none.fl_str_mv Orozco-Beltran, Domingo
Gil-Guillen, Vicente F
Redon, Josep
Martin-Moreno, Jose M
Pallarés-Carratalá, Vicente
Navarro-Perez, Jorge
Valls-Roca, Francisco
Sanchis-Domenech, Carlos
Fernandez-Gimenez, Antonio
Perez-Navarro, Ana
Bertomeu-Martinez, Vicente
Cordero, Alberto
Pascual de la Torre, Manuel
Trillo, Jose L
Carratala-Munuera, Concepcion
Pita-Fernandez, Salvador
Uso, Ruth
Durazo-Arvizu, Ramon
Cooper, Richard S
Sanz, Gines
Castellano, Jose Maria
Ascaso, Juan F
Carmena, Rafael
Tellez-Plaza, Maria
author Orozco-Beltran, Domingo
author_facet Orozco-Beltran, Domingo
Gil-Guillen, Vicente F
Redon, Josep
Martin-Moreno, Jose M
Pallarés-Carratalá, Vicente
Navarro-Perez, Jorge
Valls-Roca, Francisco
Sanchis-Domenech, Carlos
Fernandez-Gimenez, Antonio
Perez-Navarro, Ana
Bertomeu-Martinez, Vicente
Cordero, Alberto
Pascual de la Torre, Manuel
Trillo, Jose L
Carratala-Munuera, Concepcion
Pita-Fernandez, Salvador
Uso, Ruth
Durazo-Arvizu, Ramon
Cooper, Richard S
Sanz, Gines
Castellano, Jose Maria
Ascaso, Juan F
Carmena, Rafael
Tellez-Plaza, Maria
author_role author
author2 Gil-Guillen, Vicente F
Redon, Josep
Martin-Moreno, Jose M
Pallarés-Carratalá, Vicente
Navarro-Perez, Jorge
Valls-Roca, Francisco
Sanchis-Domenech, Carlos
Fernandez-Gimenez, Antonio
Perez-Navarro, Ana
Bertomeu-Martinez, Vicente
Cordero, Alberto
Pascual de la Torre, Manuel
Trillo, Jose L
Carratala-Munuera, Concepcion
Pita-Fernandez, Salvador
Uso, Ruth
Durazo-Arvizu, Ramon
Cooper, Richard S
Sanz, Gines
Castellano, Jose Maria
Ascaso, Juan F
Carmena, Rafael
Tellez-Plaza, Maria
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv Adult
Aged
Cardiovascular Diseases
Cholesterol, HDL
Cholesterol, LDL
Coronary Disease
Diabetes Mellitus
Female
Hospitalization
Humans
Hypertension
Lipids
Male
Middle Aged
Risk Factors
Stroke
Triglycerides
topic Adult
Aged
Cardiovascular Diseases
Cholesterol, HDL
Cholesterol, LDL
Coronary Disease
Diabetes Mellitus
Female
Hospitalization
Humans
Hypertension
Lipids
Male
Middle Aged
Risk Factors
Stroke
Triglycerides
description Introduction: The potential impact of targeting different components of an adverse lipid profile in populations with multiple cardiovascular risk factors is not completely clear. This study aims to assess the association between different components of the standard lipid profile with all-cause mortality and hospitalization due to cardiovascular events in a high-risk population. Methods: This prospective registry included high risk adults over 30 years old free of cardiovascular disease (2008-2012). Diagnosis of hypertension, dyslipidemia or diabetes mellitus was inclusion criterion. Lipid biomarkers were evaluated. Primary endpoints were all-cause mortality and hospital admission due to coronary heart disease or stroke. We estimated adjusted rate ratios (aRR), absolute risk differences and population attributable risk associated with adverse lipid profiles. Results: 51,462 subjects were included with a mean age of 62.6 years (47.6% men). During an average follow-up of 3.2 years, 919 deaths, 1666 hospitalizations for coronary heart disease and 1510 hospitalizations for stroke were recorded. The parameters that showed an increased rate for total mortality, coronary heart disease and stroke hospitalization were, respectively, low HDL-Cholesterol: aRR 1.25, 1.29 and 1.23; high Total/HDL-Cholesterol: aRR 1.22, 1.38 and 1.25; and high Triglycerides/HDL-Cholesterol: aRR 1.21, 1.30, 1.09. The parameters that showed highest population attributable risk (%) were, respectively, low HDL-Cholesterol: 7.70, 11.42, 8.40; high Total/HDL-Cholesterol: 6.55, 12.47, 8.73; and high Triglycerides/HDL-Cholesterol: 8.94, 15.09, 6.92. Conclusions: In a population with cardiovascular risk factors, HDL-cholesterol, Total/HDL-cholesterol and triglycerides/HDL-cholesterol ratios were associated with a higher population attributable risk for cardiovascular disease compared to other common biomarkers.
publishDate 2017
dc.date.none.fl_str_mv 2017
2017-10-18
2017
2017-10-18
2021
2021-09-14
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12105/13382
url http://hdl.handle.net/20.500.12105/13382
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 4.0 Internacional
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 4.0 Internacional
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/octet-stream
dc.publisher.none.fl_str_mv Public Library of Science (PLOS)
publisher.none.fl_str_mv Public Library of Science (PLOS)
dc.source.none.fl_str_mv reponame:Repisalud
instname:Instituto de Salud Carlos III (ISCIII)
instname_str Instituto de Salud Carlos III (ISCIII)
reponame_str Repisalud
collection Repisalud
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812455

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