Pleiotrophin as a central nervous system neuromodulator, evidences from the hippocampus

Pleiotrophin (PTN) is a secreted growth factor, and also a cytokine, associated with the extracellular matrix, which has recently starting to attract attention as a significant neuromodulator with multiple neuronal functions during development. PTN is expressed in several tissues, where its signals...

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Detalhes bibliográficos
Autores: González Castillo, Celia, Ortuño Sahagún, Daniel, Guzmán-Brambila, Carolina, Pallàs i Llibería, Mercè, 1964-, Rojas-Mayorquín, Argelia E.
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2015
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/65531
Acesso em linha:https://hdl.handle.net/2445/65531
Access Level:acceso abierto
Palavra-chave:Sistema nerviós central
Hipocamp (Cervell)
Neuropèptids
Citoquines
Neurobiologia
Central nervous system
Hippocampus (Brain)
Neuropeptides
Cytokines
Neurobiology
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spelling Pleiotrophin as a central nervous system neuromodulator, evidences from the hippocampusGonzález Castillo, CeliaOrtuño Sahagún, DanielGuzmán-Brambila, CarolinaPallàs i Llibería, Mercè, 1964-Rojas-Mayorquín, Argelia E.Sistema nerviós centralHipocamp (Cervell)NeuropèptidsCitoquinesNeurobiologiaCentral nervous systemHippocampus (Brain)NeuropeptidesCytokinesNeurobiologyPleiotrophin (PTN) is a secreted growth factor, and also a cytokine, associated with the extracellular matrix, which has recently starting to attract attention as a significant neuromodulator with multiple neuronal functions during development. PTN is expressed in several tissues, where its signals are generally related with cell proliferation, growth, and differentiation by acting through different receptors. In Central Nervous System (CNS), PTN exerts post-developmental neurotrophic and -protective effects, and additionally has been involved in neurodegenerative diseases and neural disorders. Studies in Drosophila shed light on some aspects of the different levels of regulatory control of PTN invertebrate homologs. Specifically in hippocampus, recent evidence from PTN Knock-out (KO) mice involves PTN functioning in learning and memory. In this paper, we summarize, discuss, and contrast the most recent advances and results that lead to proposing a PTN as a neuromodulatory molecule in the CNS, particularly in hippocampus.Frontiers Media2015201520152015info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion7 p.application/pdfapplication/pdfhttps://hdl.handle.net/2445/65531Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: http://dx.doi.org/10.3389/fncel.2014.00443Frontiers in Cellular Neuroscience, 2015, vol. 8, p. 443http://dx.doi.org/10.3389/fncel.2014.00443cc-by (c) González-Castillo, Celia et al., 2015http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:recercat.cat:2445/655312026-05-29T05:05:01Z
dc.title.none.fl_str_mv Pleiotrophin as a central nervous system neuromodulator, evidences from the hippocampus
title Pleiotrophin as a central nervous system neuromodulator, evidences from the hippocampus
spellingShingle Pleiotrophin as a central nervous system neuromodulator, evidences from the hippocampus
González Castillo, Celia
Sistema nerviós central
Hipocamp (Cervell)
Neuropèptids
Citoquines
Neurobiologia
Central nervous system
Hippocampus (Brain)
Neuropeptides
Cytokines
Neurobiology
title_short Pleiotrophin as a central nervous system neuromodulator, evidences from the hippocampus
title_full Pleiotrophin as a central nervous system neuromodulator, evidences from the hippocampus
title_fullStr Pleiotrophin as a central nervous system neuromodulator, evidences from the hippocampus
title_full_unstemmed Pleiotrophin as a central nervous system neuromodulator, evidences from the hippocampus
title_sort Pleiotrophin as a central nervous system neuromodulator, evidences from the hippocampus
dc.creator.none.fl_str_mv González Castillo, Celia
Ortuño Sahagún, Daniel
Guzmán-Brambila, Carolina
Pallàs i Llibería, Mercè, 1964-
Rojas-Mayorquín, Argelia E.
author González Castillo, Celia
author_facet González Castillo, Celia
Ortuño Sahagún, Daniel
Guzmán-Brambila, Carolina
Pallàs i Llibería, Mercè, 1964-
Rojas-Mayorquín, Argelia E.
author_role author
author2 Ortuño Sahagún, Daniel
Guzmán-Brambila, Carolina
Pallàs i Llibería, Mercè, 1964-
Rojas-Mayorquín, Argelia E.
author2_role author
author
author
author
dc.subject.none.fl_str_mv Sistema nerviós central
Hipocamp (Cervell)
Neuropèptids
Citoquines
Neurobiologia
Central nervous system
Hippocampus (Brain)
Neuropeptides
Cytokines
Neurobiology
topic Sistema nerviós central
Hipocamp (Cervell)
Neuropèptids
Citoquines
Neurobiologia
Central nervous system
Hippocampus (Brain)
Neuropeptides
Cytokines
Neurobiology
description Pleiotrophin (PTN) is a secreted growth factor, and also a cytokine, associated with the extracellular matrix, which has recently starting to attract attention as a significant neuromodulator with multiple neuronal functions during development. PTN is expressed in several tissues, where its signals are generally related with cell proliferation, growth, and differentiation by acting through different receptors. In Central Nervous System (CNS), PTN exerts post-developmental neurotrophic and -protective effects, and additionally has been involved in neurodegenerative diseases and neural disorders. Studies in Drosophila shed light on some aspects of the different levels of regulatory control of PTN invertebrate homologs. Specifically in hippocampus, recent evidence from PTN Knock-out (KO) mice involves PTN functioning in learning and memory. In this paper, we summarize, discuss, and contrast the most recent advances and results that lead to proposing a PTN as a neuromodulatory molecule in the CNS, particularly in hippocampus.
publishDate 2015
dc.date.none.fl_str_mv 2015
2015
2015
2015
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/65531
url https://hdl.handle.net/2445/65531
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: http://dx.doi.org/10.3389/fncel.2014.00443
Frontiers in Cellular Neuroscience, 2015, vol. 8, p. 443
http://dx.doi.org/10.3389/fncel.2014.00443
dc.rights.none.fl_str_mv cc-by (c) González-Castillo, Celia et al., 2015
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) González-Castillo, Celia et al., 2015
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 7 p.
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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