Genetic variants of CTLA4 are associated with clinical outcome of patients with multiple myeloma

Immune dysfunction in patients with multiple myeloma (MM) affects both the innate and adaptive immune system. Molecules involved in the immune checkpoint pathways are essential to determine the ability of cancer cells to escape from the immune system surveillance. However, few data are available con...

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Autores: Gonzalez Montes, Yolanda, Rodriguez Romanos, Rocío, Villavicencio, Alicia, Osca Gelis, Gemma, González Bártulos, Marta, Llopis, Francesca, Clapes, Victòria, Oriol, Albert, Sureda, Anna, Escoda, Lourdes, Sarrà, Josep, Garzó, Ana, Lloveras, Natàlia, Díez, Isabel, Granada, Isabel, Gallardo, David
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/198590
Acceso en línea:https://hdl.handle.net/2445/198590
Access Level:acceso abierto
Palabra clave:Mieloma múltiple
Citogenètica
Polimorfisme genètic
Medul·la òssia
Multiple myeloma
Cytogenetics
Genetic polymorphisms
Bone marrow
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spelling Genetic variants of CTLA4 are associated with clinical outcome of patients with multiple myelomaGonzalez Montes, YolandaRodriguez Romanos, RocíoVillavicencio, AliciaOsca Gelis, GemmaGonzález Bártulos, MartaLlopis, FrancescaClapes, VictòriaOriol, AlbertSureda, AnnaEscoda, LourdesSarrà, JosepGarzó, AnaLloveras, NatàliaDíez, IsabelGranada, IsabelGallardo, DavidMieloma múltipleCitogenèticaPolimorfisme genèticMedul·la òssiaMultiple myelomaCytogeneticsGenetic polymorphismsBone marrowImmune dysfunction in patients with multiple myeloma (MM) affects both the innate and adaptive immune system. Molecules involved in the immune checkpoint pathways are essential to determine the ability of cancer cells to escape from the immune system surveillance. However, few data are available concerning the role of these molecules in predicting the kinetics of progression of MM. We retrospectively analysed polymorphisms of CTLA4 (rs231775 and rs733618), BTLA (rs9288953), CD28 (rs3116496), PD-1 (rs36084323 and rs11568821) and LAG-3 (rs870849) genes in 239 patients with newly diagnosed MM. Patients with a CTLA4 rs231775 AA/AG genotype showed a median progression-free survival (PFS) significantly lower than those with GG genotype (32.3 months versus 96.8 months respectively; p: 0.008). The 5-year PFS rate was 25% for patients with grouped AA and AG genotype vs 55.4% for patients with GG genotype. Multivariate analysis confirmed the CTLA4 rs231775 genotype as an independent risk factor for PFS (Hazard Ratio (HR): 2.05; 95% CI: 1.0-6.2; p: 0.047). Our results suggest that the CTLA4 genotype may identify patients with earlier progression of MM. This polymorphism could potentially be used as a prognostic biomarker.Frontiers Media SA2023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/198590Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.3389/fimmu.2023.1158105Frontiers in Immunology, 2023, vol. 14, num. 1158105https://doi.org/10.3389/fimmu.2023.1158105cc by (c) Gonzalez Montes, Yolanda et al., 2023http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1985902026-05-27T06:46:51Z
dc.title.none.fl_str_mv Genetic variants of CTLA4 are associated with clinical outcome of patients with multiple myeloma
title Genetic variants of CTLA4 are associated with clinical outcome of patients with multiple myeloma
spellingShingle Genetic variants of CTLA4 are associated with clinical outcome of patients with multiple myeloma
Gonzalez Montes, Yolanda
Mieloma múltiple
Citogenètica
Polimorfisme genètic
Medul·la òssia
Multiple myeloma
Cytogenetics
Genetic polymorphisms
Bone marrow
title_short Genetic variants of CTLA4 are associated with clinical outcome of patients with multiple myeloma
title_full Genetic variants of CTLA4 are associated with clinical outcome of patients with multiple myeloma
title_fullStr Genetic variants of CTLA4 are associated with clinical outcome of patients with multiple myeloma
title_full_unstemmed Genetic variants of CTLA4 are associated with clinical outcome of patients with multiple myeloma
title_sort Genetic variants of CTLA4 are associated with clinical outcome of patients with multiple myeloma
dc.creator.none.fl_str_mv Gonzalez Montes, Yolanda
Rodriguez Romanos, Rocío
Villavicencio, Alicia
Osca Gelis, Gemma
González Bártulos, Marta
Llopis, Francesca
Clapes, Victòria
Oriol, Albert
Sureda, Anna
Escoda, Lourdes
Sarrà, Josep
Garzó, Ana
Lloveras, Natàlia
Díez, Isabel
Granada, Isabel
Gallardo, David
author Gonzalez Montes, Yolanda
author_facet Gonzalez Montes, Yolanda
Rodriguez Romanos, Rocío
Villavicencio, Alicia
Osca Gelis, Gemma
González Bártulos, Marta
Llopis, Francesca
Clapes, Victòria
Oriol, Albert
Sureda, Anna
Escoda, Lourdes
Sarrà, Josep
Garzó, Ana
Lloveras, Natàlia
Díez, Isabel
Granada, Isabel
Gallardo, David
author_role author
author2 Rodriguez Romanos, Rocío
Villavicencio, Alicia
Osca Gelis, Gemma
González Bártulos, Marta
Llopis, Francesca
Clapes, Victòria
Oriol, Albert
Sureda, Anna
Escoda, Lourdes
Sarrà, Josep
Garzó, Ana
Lloveras, Natàlia
Díez, Isabel
Granada, Isabel
Gallardo, David
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Mieloma múltiple
Citogenètica
Polimorfisme genètic
Medul·la òssia
Multiple myeloma
Cytogenetics
Genetic polymorphisms
Bone marrow
topic Mieloma múltiple
Citogenètica
Polimorfisme genètic
Medul·la òssia
Multiple myeloma
Cytogenetics
Genetic polymorphisms
Bone marrow
description Immune dysfunction in patients with multiple myeloma (MM) affects both the innate and adaptive immune system. Molecules involved in the immune checkpoint pathways are essential to determine the ability of cancer cells to escape from the immune system surveillance. However, few data are available concerning the role of these molecules in predicting the kinetics of progression of MM. We retrospectively analysed polymorphisms of CTLA4 (rs231775 and rs733618), BTLA (rs9288953), CD28 (rs3116496), PD-1 (rs36084323 and rs11568821) and LAG-3 (rs870849) genes in 239 patients with newly diagnosed MM. Patients with a CTLA4 rs231775 AA/AG genotype showed a median progression-free survival (PFS) significantly lower than those with GG genotype (32.3 months versus 96.8 months respectively; p: 0.008). The 5-year PFS rate was 25% for patients with grouped AA and AG genotype vs 55.4% for patients with GG genotype. Multivariate analysis confirmed the CTLA4 rs231775 genotype as an independent risk factor for PFS (Hazard Ratio (HR): 2.05; 95% CI: 1.0-6.2; p: 0.047). Our results suggest that the CTLA4 genotype may identify patients with earlier progression of MM. This polymorphism could potentially be used as a prognostic biomarker.
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/198590
url https://hdl.handle.net/2445/198590
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3389/fimmu.2023.1158105
Frontiers in Immunology, 2023, vol. 14, num. 1158105
https://doi.org/10.3389/fimmu.2023.1158105
dc.rights.none.fl_str_mv cc by (c) Gonzalez Montes, Yolanda et al., 2023
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by (c) Gonzalez Montes, Yolanda et al., 2023
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers Media SA
publisher.none.fl_str_mv Frontiers Media SA
dc.source.none.fl_str_mv Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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