Genetic variants of CTLA4 are associated with clinical outcome of patients with multiple myeloma

Immune dysfunction in patients with multiple myeloma (MM) affects both the innate and adaptive immune system. Molecules involved in the immune checkpoint pathways are essential to determine the ability of cancer cells to escape from the immune system surveillance. However, few data are available con...

ver descrição completa

Detalhes bibliográficos
Autores: Gonzalez Montes, Yolanda, Rodriguez Romanos, Rocío, Villavicencio Obando, Alicia Silvana, Osca-Gelis, Gemma, González-Bártulos, Marta, Llopis, Francesca, Clapes, Victòria, Oriol, Albert, Sureda, Anna, Escoda, Lourdes, Sarrà, Josep, Garzó, Ana, Lloveras Guelque, Natàlia, Díez de la Lastra, Isabel, Granada, Isabel, Gallardo, David
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10256/25113
Acesso em linha:http://hdl.handle.net/10256/25113
Access Level:acceso abierto
Palavra-chave:Mieloma múltiple -- Aspectes genètics
Multiple myeloma -- Genetic aspects
Citogenètica
Cytogenetics
Genètica molecular
Molecular genetics
Descrição
Resumo:Immune dysfunction in patients with multiple myeloma (MM) affects both the innate and adaptive immune system. Molecules involved in the immune checkpoint pathways are essential to determine the ability of cancer cells to escape from the immune system surveillance. However, few data are available concerning the role of these molecules in predicting the kinetics of progression of MM. We retrospectively analysed polymorphisms of CTLA4 (rs231775 and rs733618), BTLA (rs9288953), CD28 (rs3116496), PD-1 (rs36084323 and rs11568821) and LAG-3 (rs870849) genes in 239 patients with newly diagnosed MM. Patients with a CTLA4 rs231775 AA/AG genotype showed a median progression-free survival (PFS) significantly lower than those with GG genotype (32.3 months versus 96.8 months respectively; p: 0.008). The 5-year PFS rate was 25% for patients with grouped AA and AG genotype vs 55.4% for patients with GG genotype. Multivariate analysis confirmed the CTLA4 rs231775 genotype as an independent risk factor for PFS (Hazard Ratio (HR): 2.05; 95% CI: 1.0-6.2; p: 0.047). Our results suggest that the CTLA4 genotype may identify patients with earlier progression of MM. This polymorphism could potentially be used as a prognostic biomarker

Registos relacionados