Olive pomace phenolic compounds stability and safety evaluation: from raw material to future ophthalmic applications

Producción Científica

Detalles Bibliográficos
Autores: Katsinas, Nicolaos, Enriquez De Salamanca Aladro, Amalia, Bento da Silva, Andreia, Bronze, Maria Rosario, Rodríguez Rojo, Soraya
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Universidad de Valladolid
Repositorio:UVaDOC. Repositorio Documental de la Universidad de Valladolid
OAI Identifier:oai:uvadoc.uva.es:10324/55611
Acceso en línea:https://doi.org/10.3390/molecules26196002
https://uvadoc.uva.es/handle/10324/55611
Access Level:acceso abierto
Palabra clave:Ojo - Enfermedades y defectos - Tratamiento
Aceite de oliva
Aceite de oliva - Análisis
Olive pomace
Phenolic extracts
3201.09 Oftalmología
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spelling Olive pomace phenolic compounds stability and safety evaluation: from raw material to future ophthalmic applicationsKatsinas, NicolaosEnriquez De Salamanca Aladro, AmaliaBento da Silva, AndreiaBronze, Maria RosarioRodríguez Rojo, SorayaOjo - Enfermedades y defectos - TratamientoAceite de olivaAceite de oliva - AnálisisOlive pomacePhenolic extracts3201.09 OftalmologíaProducción CientíficaNowadays, increasing interest in olive pomace (OP) valorization aims to improve olive’s industry sustainability. Interestingly, several studies propose a high-value application for OP extracts containing its main phenolic compounds, hydroxytyrosol and oleuropein, as therapy for ocular surface diseases. In this work, the stability and accessibility of OP total phenolic and flavonoid content, main representative compounds, and antioxidant activity were assessed under different pretreatment conditions. Among them, lyophilization and supercritical CO2 extraction were found to increase significantly most responses measured in the produced extracts. Two selected extracts (CONV and OPT3) were obtained by different techniques (conventional and pressurized liquid extraction); Their aqueous solutions were characterized by HPLC-DAD-MS/MS. Additionally, their safety and stability were evaluated according to EMA requirements towards their approval as ophthalmic products: their genotoxic effect on ocular surface cells and their 6-months storage stability at 4 different temperature/moisture conditions (CPMP/ICH/2736/99), together with pure hydroxytyrosol and oleuropein solutions. The concentration of hydroxytyrosol and oleuropein in pure or extract solutions was tracked, and possible degradation products were putatively identified by HPLC-DAD-MS/MS. Hydroxytyrosol and oleuropein had different stability as standard or extract solutions, with oleuropein also showing different degradation profile. All compounds/extracts were safe for ophthalmic use at the concentrations tested.European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie Initial Training Network (ITN) “IT-DED3” (H2020-MSCA-ITN-2017) grant agreement No. 765608Fundação para a Ciência e Tecnologia (FCT) and Portugal 2020 to the Portuguese Mass Spectrometry Network (Rede Nacional de Espectrometria de Massa RNEM; LISBOA 01 0145 FEDER 402 022125)MDPI2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://doi.org/10.3390/molecules26196002https://uvadoc.uva.es/handle/10324/55611reponame:UVaDOC. Repositorio Documental de la Universidad de Valladolidinstname:Universidad de ValladolidIngléshttps://www.mdpi.com/1420-3049/26/19/6002info:eu-repo/grantAgreement/EC/H2020/765608info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/oai:uvadoc.uva.es:10324/556112026-06-13T12:44:47Z
dc.title.none.fl_str_mv Olive pomace phenolic compounds stability and safety evaluation: from raw material to future ophthalmic applications
title Olive pomace phenolic compounds stability and safety evaluation: from raw material to future ophthalmic applications
spellingShingle Olive pomace phenolic compounds stability and safety evaluation: from raw material to future ophthalmic applications
Katsinas, Nicolaos
Ojo - Enfermedades y defectos - Tratamiento
Aceite de oliva
Aceite de oliva - Análisis
Olive pomace
Phenolic extracts
3201.09 Oftalmología
title_short Olive pomace phenolic compounds stability and safety evaluation: from raw material to future ophthalmic applications
title_full Olive pomace phenolic compounds stability and safety evaluation: from raw material to future ophthalmic applications
title_fullStr Olive pomace phenolic compounds stability and safety evaluation: from raw material to future ophthalmic applications
title_full_unstemmed Olive pomace phenolic compounds stability and safety evaluation: from raw material to future ophthalmic applications
title_sort Olive pomace phenolic compounds stability and safety evaluation: from raw material to future ophthalmic applications
dc.creator.none.fl_str_mv Katsinas, Nicolaos
Enriquez De Salamanca Aladro, Amalia
Bento da Silva, Andreia
Bronze, Maria Rosario
Rodríguez Rojo, Soraya
author Katsinas, Nicolaos
author_facet Katsinas, Nicolaos
Enriquez De Salamanca Aladro, Amalia
Bento da Silva, Andreia
Bronze, Maria Rosario
Rodríguez Rojo, Soraya
author_role author
author2 Enriquez De Salamanca Aladro, Amalia
Bento da Silva, Andreia
Bronze, Maria Rosario
Rodríguez Rojo, Soraya
author2_role author
author
author
author
dc.subject.none.fl_str_mv Ojo - Enfermedades y defectos - Tratamiento
Aceite de oliva
Aceite de oliva - Análisis
Olive pomace
Phenolic extracts
3201.09 Oftalmología
topic Ojo - Enfermedades y defectos - Tratamiento
Aceite de oliva
Aceite de oliva - Análisis
Olive pomace
Phenolic extracts
3201.09 Oftalmología
description Producción Científica
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.3390/molecules26196002
https://uvadoc.uva.es/handle/10324/55611
url https://doi.org/10.3390/molecules26196002
https://uvadoc.uva.es/handle/10324/55611
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://www.mdpi.com/1420-3049/26/19/6002
info:eu-repo/grantAgreement/EC/H2020/765608
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:UVaDOC. Repositorio Documental de la Universidad de Valladolid
instname:Universidad de Valladolid
instname_str Universidad de Valladolid
reponame_str UVaDOC. Repositorio Documental de la Universidad de Valladolid
collection UVaDOC. Repositorio Documental de la Universidad de Valladolid
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.301603

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