Microalga Nannochloropsis gaditana as a sustainable source of bioactive peptides: A proteomic and in silico approach

This article belongs to the Special Issue Proteins from Plants or Animals: Enriching the Characteristics of Food.

Detalles Bibliográficos
Autores: Paterson, Samuel, Alonso-Pintre, Laura, Morato-López, Esperanza, González-De la Fuente, Sandra, Gómez-Cortés, Pilar, Hernández-Ledesma, Blanca
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/390781
Acceso en línea:http://hdl.handle.net/10261/390781
Access Level:acceso abierto
Palabra clave:Microalgae
Nannochloropsis sp.
Proteomics
In silico digestion
Functional analysis
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spelling Microalga Nannochloropsis gaditana as a sustainable source of bioactive peptides: A proteomic and in silico approachPaterson, SamuelAlonso-Pintre, LauraMorato-López, EsperanzaGonzález-De la Fuente, SandraGómez-Cortés, PilarHernández-Ledesma, BlancaMicroalgaeNannochloropsis sp.ProteomicsIn silico digestionFunctional analysisThis article belongs to the Special Issue Proteins from Plants or Animals: Enriching the Characteristics of Food.The impact of the world’s growing population on food systems and the role of dietary patterns in the management of non-communicable diseases underscore the need to explore sustainable and dietary protein sources. Although microalgae have stood out as alternative sources of proteins and bioactive peptides, some species such as Nannochloropsis gaditana remain unexplored. This study aimed to characterize N. gaditana’s proteome and evaluate its potential as a source of bioactive peptides by using an in silico approach. A total of 1955 proteins were identified and classified into functional groups of cellular components, molecular functions, and biological processes. In silico gastrointestinal digestion of identified proteins demonstrated that 202 hydrophobic and low-molecular-size peptides with potential bioactivity were released. Among them, 27 exhibited theorical antioxidant, antihypertensive, antidiabetic, anti-inflammatory, and/or antimicrobial activities. Seven of twenty-seven peptides showed ≥20% intestinal absorption, suggesting potential systemic effects, while the rest could act at local level. Molecular docking demonstrated strong affinities with key enzymes such as MPO, ACE, and DPPIV. Resistance to the digestion, capacity to be absorbed, and multifunctionality were demonstrated for peptide FIPGL. This study highlights N. gaditana’s potential as a sustainable source of novel potential bioactive peptides with promising local and systemic biological effects.This work was supported through Project PID2021-122989OB-I00 financed by MICIU/AEI/10.13039/501100011033 and FEDER, EU. Samuel Paterson gratefully acknowledges the Comunidad Autónoma de Madrid for a predoctoral contract (PIPF-2022/BIO-24996).Peer reviewedMultidisciplinary Digital Publishing InstituteAgencia Estatal de Investigación (España)Ministerio de Ciencia, Innovación y Universidades (España)European CommissionComunidad de MadridConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202520252025info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/390781reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2021-122989OB-I00PIPF-2022/BIO-24996Paterson, Samuel; Alonso-Pintre, Laura; Morato-López, Esperanza; González-De la Fuente, Sandra; Gómez-Cortés, Pilar; Hernández-Ledesma, Blanca; 2025; Supplementary Materials: Microalga Nannochloropsis gaditana as a sustainable source of bioactive peptides: A proteomic and in silico approach [Dataset]; Multidisciplinary Digital Publishing Institute; https://doi.org/10.3390/foods14020252https://doi.org/10.3390/foods14020252Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3907812026-05-22T06:33:51Z
dc.title.none.fl_str_mv Microalga Nannochloropsis gaditana as a sustainable source of bioactive peptides: A proteomic and in silico approach
title Microalga Nannochloropsis gaditana as a sustainable source of bioactive peptides: A proteomic and in silico approach
spellingShingle Microalga Nannochloropsis gaditana as a sustainable source of bioactive peptides: A proteomic and in silico approach
Paterson, Samuel
Microalgae
Nannochloropsis sp.
Proteomics
In silico digestion
Functional analysis
title_short Microalga Nannochloropsis gaditana as a sustainable source of bioactive peptides: A proteomic and in silico approach
title_full Microalga Nannochloropsis gaditana as a sustainable source of bioactive peptides: A proteomic and in silico approach
title_fullStr Microalga Nannochloropsis gaditana as a sustainable source of bioactive peptides: A proteomic and in silico approach
title_full_unstemmed Microalga Nannochloropsis gaditana as a sustainable source of bioactive peptides: A proteomic and in silico approach
title_sort Microalga Nannochloropsis gaditana as a sustainable source of bioactive peptides: A proteomic and in silico approach
dc.creator.none.fl_str_mv Paterson, Samuel
Alonso-Pintre, Laura
Morato-López, Esperanza
González-De la Fuente, Sandra
Gómez-Cortés, Pilar
Hernández-Ledesma, Blanca
author Paterson, Samuel
author_facet Paterson, Samuel
Alonso-Pintre, Laura
Morato-López, Esperanza
González-De la Fuente, Sandra
Gómez-Cortés, Pilar
Hernández-Ledesma, Blanca
author_role author
author2 Alonso-Pintre, Laura
Morato-López, Esperanza
González-De la Fuente, Sandra
Gómez-Cortés, Pilar
Hernández-Ledesma, Blanca
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Agencia Estatal de Investigación (España)
Ministerio de Ciencia, Innovación y Universidades (España)
European Commission
Comunidad de Madrid
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Microalgae
Nannochloropsis sp.
Proteomics
In silico digestion
Functional analysis
topic Microalgae
Nannochloropsis sp.
Proteomics
In silico digestion
Functional analysis
description This article belongs to the Special Issue Proteins from Plants or Animals: Enriching the Characteristics of Food.
publishDate 2025
dc.date.none.fl_str_mv 2025
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/390781
url http://hdl.handle.net/10261/390781
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2021-122989OB-I00
PIPF-2022/BIO-24996
Paterson, Samuel; Alonso-Pintre, Laura; Morato-López, Esperanza; González-De la Fuente, Sandra; Gómez-Cortés, Pilar; Hernández-Ledesma, Blanca; 2025; Supplementary Materials: Microalga Nannochloropsis gaditana as a sustainable source of bioactive peptides: A proteomic and in silico approach [Dataset]; Multidisciplinary Digital Publishing Institute; https://doi.org/10.3390/foods14020252
https://doi.org/10.3390/foods14020252
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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