Designing and repurposing drugs to target intrinsically disordered proteins for cancer treatment: using NUPR1 as a paradigm

3 pags, 1 fig

Detalles Bibliográficos
Autores: Santofimia-Castaño, Patricia, Rizzuti, Bruno, Xia, Yi, Abian, Olga, Peng, Ling, Velázquez-Campoy, Adrián, Iovanna, Juan Lucio, Neira, José L.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/257709
Acceso en línea:http://hdl.handle.net/10261/257709
https://api.elsevier.com/content/abstract/scopus_id/85066014692
Access Level:acceso abierto
Palabra clave:Drug design
NUPR1
Intrinsically disordered protein
Molecular dynamics
Protein-protein interactions
Spectroscopy
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spelling Designing and repurposing drugs to target intrinsically disordered proteins for cancer treatment: using NUPR1 as a paradigmSantofimia-Castaño, PatriciaRizzuti, BrunoXia, YiAbian, OlgaPeng, LingVelázquez-Campoy, AdriánIovanna, Juan LucioNeira, José L.Drug designNUPR1Intrinsically disordered proteinMolecular dynamicsProtein-protein interactionsSpectroscopy3 pags, 1 figIntrinsically disordered proteins (IDPs) do not have a well-defined structure, but they have key biological tasks in cancer development. By using the disordered cancer-related protein NUPR1 as a proof-of-concept, we have developed a new multidisciplinary approach to tackle drug-design against IDPs, using it to repurpose drugs for treating pancreatic adenocarcinoma (PDAC).This work in the authors' laboratories was supported by [La Ligue Contre le Cancer], INCa, [Canceropole PACA] and [INSERM] to JLI and LP; [Miguel Servet Program from Instituto de Salud Carlos III] under grant [CPII13/00017] to OA; Fondo de Investigaciones Sanitarias from Instituto de Salud Carlos III, and European Union (ERDF/ESF, 'Investing in your future') under grants [PI15/00663 and PI18/00349] to OA; Ministerio de Economia, Industria y Competitividad, Gobierno de Espana under grants [BFU2016-78232-P to AVC, CTQ2015-64445-R to JLN]; [Diputacion General de Aragon] under grants [Protein Targets and Bioactive Compound Group to AVC, and Digestive Pathology Group to OA]; [Centro de Investigacion Biomedica en Red en Enfermedades Hepaticas y Digestivas] (CIBERehd) toOAand AVC; [Programme XUGUANGQI] to YX and JLI; and [National Natural Science Foundation of China (81502920), the Fundamental Research Funds for the Central Universities] under grant [106112017CDJQJ468823] to YX. The Fundacion Alfonso Martin-Escudero and Fondation de France supported to PSC.Peer reviewedTaylor & FrancisLigue Nationale contre le Cancer (France)Canceropole PACAInstitut National de la Santé et de la Recherche Médicale (France)Instituto de Salud Carlos IIIEuropean CommissionMinisterio de Economía y Competitividad (España)Diputación General de AragónCentro de Investigación Biomédica en Red Enfermedades Hepáticas y Digestivas (España)National Natural Science Foundation of ChinaFundamental Research Funds for the Central Universities (China)Fundación Alfonso Martín EscuderoFondation de FranceSantofimia-Castaño, Patricia [0000-0003-2506-5567]Rizzuti, Bruno [0000-0003-1110-764X]Xia, Yi [0000-0001-5863-7272]Abian, Olga [0000-0001-5664-1729]Peng, Ling [0000-0003-3990-5248]Velázquez-Campoy, Adrián [0000-0001-5702-4538]Iovanna, Juan L. [0000-0003-1822-2237]Neira, José L. [0000-0002-4933-0428]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202220222019info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/257709https://api.elsevier.com/content/abstract/scopus_id/85066014692reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016MINECO/ICTI2013‐2016info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016MINECO/ICTI2013‐2016Molecular & cellular oncologyhttps://doi.org/10.1080/23723556.2019.1612678Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2577092026-05-22T06:33:51Z
dc.title.none.fl_str_mv Designing and repurposing drugs to target intrinsically disordered proteins for cancer treatment: using NUPR1 as a paradigm
title Designing and repurposing drugs to target intrinsically disordered proteins for cancer treatment: using NUPR1 as a paradigm
spellingShingle Designing and repurposing drugs to target intrinsically disordered proteins for cancer treatment: using NUPR1 as a paradigm
Santofimia-Castaño, Patricia
Drug design
NUPR1
Intrinsically disordered protein
Molecular dynamics
Protein-protein interactions
Spectroscopy
title_short Designing and repurposing drugs to target intrinsically disordered proteins for cancer treatment: using NUPR1 as a paradigm
title_full Designing and repurposing drugs to target intrinsically disordered proteins for cancer treatment: using NUPR1 as a paradigm
title_fullStr Designing and repurposing drugs to target intrinsically disordered proteins for cancer treatment: using NUPR1 as a paradigm
title_full_unstemmed Designing and repurposing drugs to target intrinsically disordered proteins for cancer treatment: using NUPR1 as a paradigm
title_sort Designing and repurposing drugs to target intrinsically disordered proteins for cancer treatment: using NUPR1 as a paradigm
dc.creator.none.fl_str_mv Santofimia-Castaño, Patricia
Rizzuti, Bruno
Xia, Yi
Abian, Olga
Peng, Ling
Velázquez-Campoy, Adrián
Iovanna, Juan Lucio
Neira, José L.
author Santofimia-Castaño, Patricia
author_facet Santofimia-Castaño, Patricia
Rizzuti, Bruno
Xia, Yi
Abian, Olga
Peng, Ling
Velázquez-Campoy, Adrián
Iovanna, Juan Lucio
Neira, José L.
author_role author
author2 Rizzuti, Bruno
Xia, Yi
Abian, Olga
Peng, Ling
Velázquez-Campoy, Adrián
Iovanna, Juan Lucio
Neira, José L.
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Ligue Nationale contre le Cancer (France)
Canceropole PACA
Institut National de la Santé et de la Recherche Médicale (France)
Instituto de Salud Carlos III
European Commission
Ministerio de Economía y Competitividad (España)
Diputación General de Aragón
Centro de Investigación Biomédica en Red Enfermedades Hepáticas y Digestivas (España)
National Natural Science Foundation of China
Fundamental Research Funds for the Central Universities (China)
Fundación Alfonso Martín Escudero
Fondation de France
Santofimia-Castaño, Patricia [0000-0003-2506-5567]
Rizzuti, Bruno [0000-0003-1110-764X]
Xia, Yi [0000-0001-5863-7272]
Abian, Olga [0000-0001-5664-1729]
Peng, Ling [0000-0003-3990-5248]
Velázquez-Campoy, Adrián [0000-0001-5702-4538]
Iovanna, Juan L. [0000-0003-1822-2237]
Neira, José L. [0000-0002-4933-0428]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Drug design
NUPR1
Intrinsically disordered protein
Molecular dynamics
Protein-protein interactions
Spectroscopy
topic Drug design
NUPR1
Intrinsically disordered protein
Molecular dynamics
Protein-protein interactions
Spectroscopy
description 3 pags, 1 fig
publishDate 2019
dc.date.none.fl_str_mv 2019
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/257709
https://api.elsevier.com/content/abstract/scopus_id/85066014692
url http://hdl.handle.net/10261/257709
https://api.elsevier.com/content/abstract/scopus_id/85066014692
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016MINECO/ICTI2013‐2016
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016MINECO/ICTI2013‐2016
Molecular & cellular oncology
https://doi.org/10.1080/23723556.2019.1612678
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Taylor & Francis
publisher.none.fl_str_mv Taylor & Francis
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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